2024
Skeletal muscle TET3 promotes insulin resistance through destabilisation of PGC-1α
Liu B, Xie D, Huang X, Jin S, Dai Y, Sun X, Li D, Bennett A, Diano S, Huang Y. Skeletal muscle TET3 promotes insulin resistance through destabilisation of PGC-1α. Diabetologia 2024, 67: 724-737. PMID: 38216792, PMCID: PMC10904493, DOI: 10.1007/s00125-023-06073-5.Peer-Reviewed Original ResearchConceptsTen-eleven translocationMuscle insulin sensitivityRNA-seqPGC-1aRegulation of muscle insulin sensitivityType 2 diabetesAnalysis of RNA-seqResponse to environmental cuesGenome-wide expression profilingWild-typeHFD-fedHFD-induced insulin resistanceHigh-fat diet (HFD)-inducedExpression levelsMaintenance of glucoseSkeletal muscle insulin sensitivityAccession numbersSkeletal muscleEnhanced glucose toleranceFamily dioxygenasesMitochondrial respirationSkeletal muscle of humansEnvironmental cuesMitochondrial functionBiological processes
2020
Improving Obesity and Insulin Resistance by Targeting Skeletal Muscle MKP-1.
Bennett AM, Lawan A. Improving Obesity and Insulin Resistance by Targeting Skeletal Muscle MKP-1. Journal Of Cellular Signaling 2020, 1: 160-168. PMID: 33179019, PMCID: PMC7654974, DOI: 10.33696/signaling.1.025.Peer-Reviewed Original ResearchType 2 diabetesInsulin resistanceSkeletal muscleMetabolic diseasesTreatment of T2DMKP-1Chronic upregulationPharmacological treatmentTherapeutic strategiesObesityGlobal epidemicCalorie restrictionT2DDiabetesCurrent interventionsDiseaseMusclePotential targetingTreatmentPotential strategyUrgent needPatientsPathogenesisStress responseUpregulation