2014
Emerging Therapies for Glioblastoma
Thomas AA, Brennan CW, DeAngelis LM, Omuro AM. Emerging Therapies for Glioblastoma. JAMA Neurology 2014, 71: 1437-1444. PMID: 25244650, DOI: 10.1001/jamaneurol.2014.1701.Peer-Reviewed Original ResearchConceptsClinical trialsCommon primary malignant brain tumorPrimary malignant brain tumorCancer stemlike cellsInnovative clinical trialsBlood-brain barrierMalignant brain tumorsPatient-tailored treatmentNew radiotherapy techniquesHeterogeneous molecular featuresImmune system interactionsGrowth factor receptorTerms glioblastomaMedian survivalDisease courseImmune checkpointsTemozolomide chemotherapyMultimodal treatmentPatient enrollmentAggressive tumorsTreatment advancesBrain neoplasmsDrug exposureBrain microenvironmentMalignant gliomas
2013
Glioblastoma and Other Malignant Gliomas: A Clinical Review
Omuro A, DeAngelis LM. Glioblastoma and Other Malignant Gliomas: A Clinical Review. JAMA 2013, 310: 1842-1850. PMID: 24193082, DOI: 10.1001/jama.2013.280319.Peer-Reviewed Original ResearchConceptsMalignant gliomasRisk factorsAmerican Heart Association classification systemCommon primary malignant brain tumorPrimary malignant brain tumorGrade III tumorsStandard of careSpecific antitumor therapyMalignant brain tumorsAuthors' own filesFrequent clinical complicationEnvironmental risk factorsCertain genetic syndromesOwn filesTerms glioblastomaThromboembolic eventsCommon complicationNeurologic symptomsOverall prognosisAnnual incidenceDismal prognosisSymptom managementClinical reviewTherapeutic optionsClinical complications