2024
Perceptions of Care and Perceived Discrimination: A Qualitative Assessment of Adults Living with Sickle Cell Disease
Crusto C, Kaufman J, Harvanek Z, Nelson C, Forray A. Perceptions of Care and Perceived Discrimination: A Qualitative Assessment of Adults Living with Sickle Cell Disease. Journal Of Racial And Ethnic Health Disparities 2024, 1-10. PMID: 39227547, DOI: 10.1007/s40615-024-02153-3.Peer-Reviewed Original ResearchSickle cell diseaseHealth care providersExperiences of adultsDiagnosis of sickle cell diseaseExperiences of discriminationAssessment of adultsCare providersExperiences of biasPublic health concernTertiary medical centerThematic analysisFocus groupsPoor communicationCell diseaseOutpatient clinicTeaching hospitalPerceived discriminationMedical CenterHealth concernAverage ageParticipantsCareEthnic groupsProvidersHealthReporting Perinatal Substance Use to Child Protective Services: Obstetric Provider Perspectives on the Impact on Care
Kaufman J, Yonkers K, Maltz C, Friedhoff C, Tobon A, Mele A, Tessier-Kay M, Grechukhina O, Lipkind H, Byatt N, Forray A. Reporting Perinatal Substance Use to Child Protective Services: Obstetric Provider Perspectives on the Impact on Care. Journal Of Women's Health 2024, 33: 1501-1508. PMID: 38770764, DOI: 10.1089/jwh.2023.0822.Peer-Reviewed Original ResearchOpioid use disorderProvider perspectiveKey informant interviewsCPS involvementNurse practitionersAffect careObstetric patientsCareInformant interviewsPostpartum patientsReporting requirementsCPS reportsProvidersContent analysisPerinatal individualsUse disorderSocial workersThematic areasPatientsFearNursesMandated reportersObstetriciansPostpartumStaffProvider–patient relationships and trauma among pregnant patients with opioid‐use disorder
Doernberg M, Gilstad‐Hayden K, Yonkers K, Forray A. Provider–patient relationships and trauma among pregnant patients with opioid‐use disorder. American Journal On Addictions 2024, 33: 569-575. PMID: 38685767, DOI: 10.1111/ajad.13570.Peer-Reviewed Original ResearchProbable posttraumatic stress disorderOpioid-use disorderPosttraumatic stress disorderPregnant patientsAlliance ScaleProvider-patient relationshipStress disorderFifth EditionPregnant participantsIntegration subscaleCommunication subscaleTrauma-informed practicesTreatment trialsWeeks of pregnancyDemographic variablesDisordersSubscalesVulnerable patient populationObstetric providersPrenatal carePatient populationSevere traumaPatientsScoresParticipantsPlacental cytochrome P450 methylomes in infants exposed to prenatal opioids: exploring the effects of neonatal opioid withdrawal syndrome on health horizons
Radhakrishna U, Sadhasivam S, Radhakrishnan R, Forray A, Muvvala S, Metpally R, Patel S, Rawal R, Vishweswaraiah S, Bahado-Singh R, Nath S. Placental cytochrome P450 methylomes in infants exposed to prenatal opioids: exploring the effects of neonatal opioid withdrawal syndrome on health horizons. Frontiers In Genetics 2024, 14: 1292148. PMID: 38264209, PMCID: PMC10805101, DOI: 10.3389/fgene.2023.1292148.Peer-Reviewed Original ResearchNeonatal opioid withdrawal syndromeOpioid withdrawal syndromePlacental tissueWithdrawal syndromeLong-term clinical implicationsPrenatal opioid exposureNOWS treatmentPrenatal opioidsOpioid exposureOpioid effectsOpioid usePharmacologic treatmentCYP genesControl mothersMultiple CYP genesValuable biomarkerClinical implicationsInfantsPersonalized treatmentOpioidsCytochrome P450 enzymesInfinium MethylationEPIC BeadChipTreatmentIllumina Infinium MethylationEPIC BeadChipSyndrome
2023
Pilot study of attentional retraining for postpartum smoking relapse
Forray A, Gunter-Riley R, Maltz C, Waters A. Pilot study of attentional retraining for postpartum smoking relapse. Frontiers In Psychiatry 2023, 14: 1231702. PMID: 37900298, PMCID: PMC10603252, DOI: 10.3389/fpsyt.2023.1231702.Peer-Reviewed Original ResearchAttentional retrainingEcological momentary assessment methodologySmoking-related stimuliRelapse prevention interventionsPostpartum smoking relapseAttentional biasesAttentional biasCognitive processesSmoking cuesRelapse processAbstinent smokersSmoking relapseTreatment attendanceMobile interventionsLarge sampleCravingEMA methodologyPilot studyExploratory analysisPrevention interventionsInterventionRelapse postpartumFormer smokersTobacco smokingLeading causeEffectiveness of smoking cessation interventions among pregnant women: An updated systematic review and meta-analysis
Vila-Farinas A, Pérez-Rios M, Montes-Martinez A, Ruano-Ravina A, Forray A, Rey-Brandariz J, Candal-Pedreira C, Fernández E, Casal-Acción B, Varela-Lema L. Effectiveness of smoking cessation interventions among pregnant women: An updated systematic review and meta-analysis. Addictive Behaviors 2023, 148: 107854. PMID: 37683574, DOI: 10.1016/j.addbeh.2023.107854.Peer-Reviewed Original ResearchNicotine replacement therapyRandomized clinical trialsLong-term nicotine replacement therapyPregnant womenCessation interventionsSystematic reviewSocioeconomic statusNon-pharmacological interventionsEffectiveness of pharmacologicalRisk of biasRoB 2 toolLow socioeconomic statusHigher socioeconomic statusPrimary search strategyHeavy smokersRoutine careReplacement therapySmoking cessationPharmacologic interventionsClinical trialsEligible studiesSTUDY APPRAISALDaily smokersEligibility criteriaPsychosocial interventionsPlacental microRNA methylome signatures may serve as biomarkers and therapeutic targets for prenatally opioid-exposed infants with neonatal opioid withdrawal syndrome
Radhakrishna U, Nath S, Uppala L, Veerappa A, Forray A, Muvvala S, Metpally R, Crist R, Berrettini W, Mausi L, Vishweswaraiah S, Bahado-Singh R. Placental microRNA methylome signatures may serve as biomarkers and therapeutic targets for prenatally opioid-exposed infants with neonatal opioid withdrawal syndrome. Frontiers In Genetics 2023, 14: 1215472. PMID: 37434949, PMCID: PMC10332887, DOI: 10.3389/fgene.2023.1215472.Peer-Reviewed Original ResearchReproductive Psychiatry
Forray A, McMahon J. Reproductive Psychiatry. 2023 DOI: 10.1016/b978-0-323-95702-1.00040-3.Peer-Reviewed Original ResearchPsychiatric disordersExacerbation of psychiatric symptomsRisks of untreated psychiatric illnessTreating mood symptomsUntreated psychiatric illnessFemale sexTreatment of premenstrual disordersPerinatal periodAntipsychotic useMood symptomsPsychiatric symptomsPsychiatric illnessReproductive-age patientsSymptom stabilityPostpartum depressionPremenstrual disordersMale sexDisordersPregnant individualsSymptomsPerimenopausal symptomsReproductive risksUnique manifestationUnique considerationsBirth
2022
COVID-19 Traumatic Disaster Appraisal and Stress Symptoms Among Health Care Workers
Olson K, Fogelman N, Maturo L, Alvarado J, Ball S, Forray A, Hu M, Ivy M, Kapo J, Krystal J, Mayes L, Rohrbaugh R, Southwick S, Tebes J, Wassel B, Sinha R. COVID-19 Traumatic Disaster Appraisal and Stress Symptoms Among Health Care Workers. Journal Of Occupational And Environmental Medicine 2022, 64: 934-941. PMID: 35959912, PMCID: PMC9640251, DOI: 10.1097/jom.0000000000002673.Peer-Reviewed Original ResearchConceptsHealth care workersCare workersChronic mental healthCross-sectional evaluationTotal Worker HealthAdverse psychological outcomesPredictive factorsSevere stress eventsResponse rateCare qualityMental healthAdverse effectsPrivate practitionersHigh levelsWorkers' healthSense of controlStress symptomsPsychological outcomesLevel of educationGreater proportionHealthPandemicStress eventsSymptomsWorkersGender differences among persons entering medication treatment for opioid use disorder in the community
Di Paola A, Taweh N, Biondi BE, Forray A, Frank CA, Shaw A, Springer SA. Gender differences among persons entering medication treatment for opioid use disorder in the community. American Journal On Addictions 2022, 31: 390-395. PMID: 35652902, PMCID: PMC9463117, DOI: 10.1111/ajad.13304.Peer-Reviewed Original ResearchConceptsOpioid use disorderUse disordersQuality of lifeDSM-5 diagnosisPosttraumatic stress disorderOpioid relapseMedication useMedication historyMedication treatmentPsychiatric comorbidityPsychiatric medicationsHigh riskMOUDDepression severityGreater prevalenceGender differencesBaseline assessmentPsychological QoL.Disorder screeningStress disorderMultidisciplinary programGeneralized anxietyWomenMedicationsDisordersSupport Models for Addiction Related Treatment (SMART) for pregnant women: Study protocol of a cluster randomized trial of two treatment models for opioid use disorder in prenatal clinics
Forray A, Mele A, Byatt N, Tobon A, Gilstad-Hayden K, Hunkle K, Hong S, Lipkind H, Fiellin DA, Callaghan K, Yonkers KA. Support Models for Addiction Related Treatment (SMART) for pregnant women: Study protocol of a cluster randomized trial of two treatment models for opioid use disorder in prenatal clinics. PLOS ONE 2022, 17: e0261751. PMID: 35025898, PMCID: PMC8758001, DOI: 10.1371/journal.pone.0261751.Peer-Reviewed Original ResearchConceptsOpioid use disorderPregnant womenUse disordersPrenatal clinicsClinical trialsReproductive health cliniciansCollaborative care approachTRIAL REGISTRATION NUMBERCommunity Healthcare OutcomesMatched-pair clusterPatient treatment engagementTreatment modelObstetric providersOUD treatmentPrimary outcomeObstetrical providersPostpartum womenHealth cliniciansCare approachRegistration numberTreatment engagementRelated treatmentsHealthcare outcomesTrialsWomen
2021
Gender Differences among Criminal Justice-Involved Persons Living with HIV Interested in Extended-Release Naltrexone Treatment
Biondi BE, Frank CA, Forray A, Springer SA. Gender Differences among Criminal Justice-Involved Persons Living with HIV Interested in Extended-Release Naltrexone Treatment. Substance Abuse 2021, 42: 905-911. PMID: 33750285, PMCID: PMC8455717, DOI: 10.1080/08897077.2021.1900984.Peer-Reviewed Original ResearchConceptsSubstance use disordersOpioid use disorderMedication treatmentUse disordersAlcohol use disorderMental health severityXR-NTXAntiretroviral therapyDouble-blind placebo-controlled trialExtended-release naltrexone treatmentExtended-release naltrexonePlacebo-controlled trialCriminal justice-involved personsHealth severityGender differencesCocaine use disorderDrug use severityJustice-involved personsClinical characteristicsART adherenceNaltrexone treatmentTreatment outcomesHigh prevalenceCocaine useHIVMaternal opioid use disorder: Placental transcriptome analysis for neonatal opioid withdrawal syndrome
Radhakrishna U, Nath SK, Vishweswaraiah S, Uppala LV, Forray A, Muvvala SB, Mishra NK, Southekal S, Guda C, Govindamangalam H, Vargas D, Gardella WG, Crist RC, Berrettini WH, Metpally RP, Bahado-Singh RO. Maternal opioid use disorder: Placental transcriptome analysis for neonatal opioid withdrawal syndrome. Genomics 2021, 113: 3610-3617. PMID: 34352367, DOI: 10.1016/j.ygeno.2021.08.001.Peer-Reviewed Original ResearchConceptsNeonatal opioid withdrawal syndromeOpioid withdrawal syndromeWithdrawal syndromePrenatal opioid exposureOpioid use disorderPlacentas of infantsPlacental tissue samplesP-valueIngenuity Pathway AnalysisOpioid exposureUse disordersUnexposed controlsFDR p-valueGenes CYP1A1Tissue samplesSyndromePathway analysisCYP1A1NewbornsInfantsEtiologyApoBPlacentaGenesGRIN2AThe Collision of Mental Health, Substance Use Disorder, and Suicide
Forray A, Yonkers KA. The Collision of Mental Health, Substance Use Disorder, and Suicide. Obstetrics And Gynecology 2021, 137: 1083-1090. PMID: 33957654, DOI: 10.1097/aog.0000000000004391.Peer-Reviewed Original ResearchConceptsRisk of suicideSubstance use disordersUse disordersMental healthPerinatal periodSuicidal thoughtsReproductive health care clinicsSevere perinatal depressionHealth care clinicsCause of deathWomen's mental healthPerinatal depressionCare clinicsPerinatal womenPregnant womenDepressive episodeReproductive yearsPsychiatric illnessAmerican CollegePsychiatric disordersCareful monitoringPsychiatric conditionsSuicide attemptsChildhood adversitySuicide preventionPlacental DNA methylation profiles in opioid-exposed pregnancies and associations with the neonatal opioid withdrawal syndrome
Radhakrishna U, Vishweswaraiah S, Uppala LV, Szymanska M, Macknis J, Kumar S, Saleem-Rasheed F, Aydas B, Forray A, Muvvala SB, Mishra NK, Guda C, Carey DJ, Metpally RP, Crist RC, Berrettini WH, Bahado-Singh RO. Placental DNA methylation profiles in opioid-exposed pregnancies and associations with the neonatal opioid withdrawal syndrome. Genomics 2021, 113: 1127-1135. PMID: 33711455, DOI: 10.1016/j.ygeno.2021.03.006.Peer-Reviewed Original ResearchConceptsNeonatal opioid withdrawal syndromeOpioid withdrawal syndromeIngenuity Pathway AnalysisWithdrawal syndromeOpioid-exposed pregnanciesPlacental tissue samplesOpioid abusePlacental tissueTissue samplesPregnancyMethylation dysregulationGenome-wide methylation analysisSyndromeInfantsPathway analysisAUCDNA methylation profilesMethylation profilesGroupPathophysiologyTherapyStrong evidence
2020
Substance Use Disorder Detection Rates Among Providers of General Medical Inpatients
Serowik KL, Yonkers KA, Gilstad-Hayden K, Forray A, Zimbrean P, Martino S. Substance Use Disorder Detection Rates Among Providers of General Medical Inpatients. Journal Of General Internal Medicine 2020, 36: 668-675. PMID: 33111239, PMCID: PMC7947066, DOI: 10.1007/s11606-020-06319-7.Peer-Reviewed Original ResearchConceptsSubstance use disordersUse disordersMedical inpatientsPatient characteristicsMedical recordsGeneral medical inpatient unitsPatient self-report questionnairesGeneral medical inpatientsMedical inpatient unitsOpioid use disorderDrug use disordersNicotine use disorderPatients' medical recordsCannabis use disorderLarge teaching hospitalAlcohol use disorderDetection rateCocaine use disorderWhite patientsBlack patientsFemale patientsHispanic patientsFormal screeningInpatient providersTeaching hospitalThe short-term impact on economic outcomes of SBIRT interventions implemented in reproductive health care settings
Olmstead TA, Martino S, Ondersma SJ, Gilstad-Hayden K, Forray A, Yonkers KA. The short-term impact on economic outcomes of SBIRT interventions implemented in reproductive health care settings. Journal Of Substance Use And Addiction Treatment 2020, 120: 108179. PMID: 33298305, PMCID: PMC7733031, DOI: 10.1016/j.jsat.2020.108179.Peer-Reviewed Original ResearchConceptsReproductive health care settingsHealth care settingsGeneral health care utilizationHealth care utilizationCare settingsE-SBIRTCare utilizationReproductive health care centersRandomized clinical trialsHealth care centersPopulation of womenImpact of screeningMisused prescription medicationsMotor vehicle crashesPublic health perspectiveFuture systematic reviewsSBIRT interventionUsual careRoutine careSBIRT programEconomic outcomesPrescription medicationsCare centerClinical trialsDifferences regression modelsMobile Applications to Help Women Achieve Better Behavioral Health in the Postpartum Period
Foster D, Forray A. Mobile Applications to Help Women Achieve Better Behavioral Health in the Postpartum Period. 2020, 325-335. DOI: 10.1093/oxfordhb/9780190218058.013.28.Peer-Reviewed Original ResearchBetter behavioral healthBehavioral healthEvidence-based treatmentsSocial connectednessSocial supportTranstheoretical modelPersonalized interventionsHealth Belief ModelSocial processesTheoretical perspectivesCurrent interventionsHealth behaviorsPerinatal womenBelief ModelMobile technologySmoking cessationInterventionUser characteristicsProgram developmentTreatment deliveryPostpartum healthHealthAvoidanceConnectednessPostpartum periodThe Educational Value of Outpatient Consultation-Liaison Rotations: A White Paper From the Academy of Consultation-Liaison Psychiatry Residency Education Subcommittee
Zimbrean PC, Ernst CL, Forray A, Beach SR, Lavakumar M, Siegel AM, Soeprono T, Schwartz AC. The Educational Value of Outpatient Consultation-Liaison Rotations: A White Paper From the Academy of Consultation-Liaison Psychiatry Residency Education Subcommittee. Journal Of The Academy Of Consultation-Liaison Psychiatry 2020, 61: 436-449. PMID: 32650995, PMCID: PMC7235569, DOI: 10.1016/j.psym.2020.05.004.Peer-Reviewed Original Research
2019
Opioid Use in Pregnancy
Tobon AL, Habecker E, Forray A. Opioid Use in Pregnancy. Current Psychiatry Reports 2019, 21: 118. PMID: 31734808, PMCID: PMC10296780, DOI: 10.1007/s11920-019-1110-4.Peer-Reviewed Original ResearchConceptsNeonatal opioid withdrawal syndromeOpioid use disorderOpioid exposureOpioid useMajor public health problemNeonatal adverse outcomesOpioid withdrawal syndromeStandard of carePublic health problemTerms of incidenceIllicit drug useSignificant adverse effectsMaintenance therapyPerinatal outcomesPregnancy outcomesRecent longitudinal studiesWithdrawal syndromeFetal effectsPregnant womenAdverse outcomesLong-term effectsUse disordersDrug useHealth problemsBrain morphology