Regional Differences in Lymphomagenesis Identified through Quantification of AICDA-Mediated Subclonal Evolution in Follicular Lymphoma: Do Pesticides Play a Role?
Alpert A, Torres N, Snyder E, Rock P, Adlowitz D, Peterson D, Cupertino P, Casulo C, Burack R. Regional Differences in Lymphomagenesis Identified through Quantification of AICDA-Mediated Subclonal Evolution in Follicular Lymphoma: Do Pesticides Play a Role? Blood 2021, 138: 3505. DOI: 10.1182/blood-2021-146972.Peer-Reviewed Original ResearchActivation-induced cytidine deaminaseNon-Hodgkin's lymphomaFollicular lymphomaSubclonal evolutionSpecimens of patientsHigh groupLow groupProportion of womenLymphoma specimensTumor specimensSurrogate markerLymphomaZip codesLymphomagenesisInduce lymphomasEnvironmental risk factorsPatientsRisk factorsIGHVSomatic hypermutationBCL2Aberrant mutationsMedianWilcoxon testEpidemiological studies