Phospho- T356 RB1 predicts survival in HPV-negative squamous cell carcinoma of the head and neck
Beck TN, Kaczmar J, Handorf E, Nikonova A, Dubyk C, Peri S, Lango M, Ridge JA, Serebriiskii IG, Burtness B, Golemis EA, Mehra R. Phospho- T356 RB1 predicts survival in HPV-negative squamous cell carcinoma of the head and neck. Oncotarget 2015, 6: 18863-18874. PMID: 26265441, PMCID: PMC4662460, DOI: 10.18632/oncotarget.4321.Peer-Reviewed Original ResearchConceptsHPV-negative SCCHNSquamous cell carcinomaCell carcinomaHuman papillomavirusHPV-negative squamous cell carcinomaAdvanced squamous cell carcinomaHPV-positive diseaseCancer Genome Atlas (TCGA) dataAdjuvant radiationOverall survivalSurgical resectionPoor prognosisPrognostic valueCDK4/6 inhibitorsTumor stagePoor survivalTumor specimensDeletion of p16Tumor typesLow expressionElevated expressionHigh expressionProtein expressionTruncating mutationsRB1 phosphorylation