2017
Combination of WEE1 and AURKA inhibition in HPV negative head and neck squamous cell carcinoma.
Parameswaran J, Lee J, Sandoval-Schaefer T, Koo J, Burtness B. Combination of WEE1 and AURKA inhibition in HPV negative head and neck squamous cell carcinoma. Journal Of Clinical Oncology 2017, 35: e14105-e14105. DOI: 10.1200/jco.2017.35.15_suppl.e14105.Peer-Reviewed Original ResearchAurora kinase APhospho-histone H3Mitotic entryCell deathHNSCC cell linesMechanism of synergyDefective spindle assemblyConfocal microscopyAURKA inhibitorsCell linesChromatin organizationAURKA inhibitor MLN8237P-CDK1Spindle assemblyKinase AMitotic catastropheWestern blot analysisTumor growthFormation assaysAURKA expressionHPV-negative HNSCC cell linesCell viability assaysMouse xenograft modelPotential therapeutic targetAURKA inhibition
2014
Overview: The Pathobiology of Head and Neck Cancer
Burtness B, Golemis E. Overview: The Pathobiology of Head and Neck Cancer. Current Cancer Research 2014, 1-5. DOI: 10.1007/978-1-4614-8815-6_1.Peer-Reviewed Original ResearchSquamous cell cancerSquamous cell carcinomaHigh recurrence ratePathobiology of headPotential therapeutic targetEarly-stage cancerMultimodality therapyCell cancerRecurrence rateCell carcinomaNeck cancerDevastating cancerMetastatic cancerStage cancerDifficult diseaseTherapeutic targetSubglottic larynxCancerProtein expression changesDiseaseNeckExpression changesImproved managementHeadSCCHN