2016
Safety and clinical activity of pembrolizumab for treatment of recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-012): an open-label, multicentre, phase 1b trial
Seiwert TY, Burtness B, Mehra R, Weiss J, Berger R, Eder JP, Heath K, McClanahan T, Lunceford J, Gause C, Cheng JD, Chow LQ. Safety and clinical activity of pembrolizumab for treatment of recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-012): an open-label, multicentre, phase 1b trial. The Lancet Oncology 2016, 17: 956-965. PMID: 27247226, DOI: 10.1016/s1470-2045(16)30066-3.Peer-Reviewed Original ResearchConceptsMetastatic squamous cell carcinomaSquamous cell carcinomaDrug-related adverse eventsPost-baseline scanPhase 1b trialProportion of patientsCell carcinomaAdverse eventsPD-L1Anti-programmed death receptor 1 antibodyDeath receptor-1 (PD-1) antibodiesPositive squamous cell carcinomaActivity of pembrolizumabDose of pembrolizumabDrug-related rashMeaningful antitumour activityFull analysis setHPV-negative patientsSerious adverse eventsHPV-positive patientsPD-L1 expressionResponse Evaluation CriteriaTreatment of recurrentOverall responseDrug-related deaths
2000
In vitro collection and posttransfusion engraftment characteristics of MNCs obtained by using a new separator for autologous PBPC transplantation
Snyder EL, Baril L, Cooper DL, Min K, Mechanic S, Stoddart L, Burtness B, Seagraves P, Debelak J, Gudino M, McCullough J. In vitro collection and posttransfusion engraftment characteristics of MNCs obtained by using a new separator for autologous PBPC transplantation. Transfusion 2000, 40: 961-967. PMID: 10960524, DOI: 10.1046/j.1537-2995.2000.40080961.x.Peer-Reviewed Original ResearchConceptsEngraftment characteristicsPBPC collectionHigh-dose myeloablative chemotherapyPeripheral blood progenitor cell collectionAutologous PBPC transplantAutologous PBPC transplantationSerious adverse eventsAutologous transplant patientsNumber of CD34Cell separatorProgenitor cell collectionShort-term engraftmentAmicus deviceBlood cell separatorAmicus SeparatorPBPC rescuePBPC transplantPBPC transplantationTransplant patientsAdverse eventsMyeloablative chemotherapyMyeloablative therapyOncology patientsChemotherapeutic regimensPlatelet count