Neuronal Calcium Sensor 1 (NCS1) as a Potential Drug Target for Treatment of Wolfram Syndrome
Fischer T, Nguyen L, Ehrlich B. Neuronal Calcium Sensor 1 (NCS1) as a Potential Drug Target for Treatment of Wolfram Syndrome. The FASEB Journal 2020, 34: 1-1. DOI: 10.1096/fasebj.2020.34.s1.00556.Peer-Reviewed Original ResearchNeuronal calcium sensor-1Wolfram syndromeHigh glucose treatmentDiabetes mellitusFunction of WFS1Lack of therapyGlucose treatmentCalcium-dependent protease calpainMajority of casesRat insulinoma cellsBaseline calciumCalcium binding proteinOptical atrophyKO cellsGlucose toxicityCalcium responseCalcium homeostasisPathophysiological consequencesCTRL cellsPhospho-AktDiscovery of drugsPotential drug targetsProtease calpainGenetic causeProtein expression