2024
NCS-1 protein regulates TRPA1 channel through the PI3K pathway in breast cancer and neuronal cells
Sánchez J, Alemán A, Henao J, Olaya J, Ehrlich B. NCS-1 protein regulates TRPA1 channel through the PI3K pathway in breast cancer and neuronal cells. Journal Of Physiology And Biochemistry 2024, 80: 451-463. PMID: 38564162, PMCID: PMC11074019, DOI: 10.1007/s13105-024-01016-z.Peer-Reviewed Original ResearchConceptsTransient receptor potential channel ankyrin 1Breast cancerPI3K pathwayNCS-1Chemotherapy-induced peripheral neuropathyCa2+ channelsK pathwayCa2+ influxNCS-1 expressionBreast cancer cellsCa2+ sensorCa2+ homeostasisCa2+ dynamicsNeuronal calcium sensor-1MDA-MB-231Fura-2Open probabilityPain sensationAnkyrin 1Peripheral neuropathyTRPA1 channelsCo-immunoprecipitationChannel functionRegulatory componentsCellular pathways
2023
Calcium signaling in chemotherapy-induced neuropathy
Fonseca M, Marazzi-Diniz P, Leite M, Ehrlich B. Calcium signaling in chemotherapy-induced neuropathy. Cell Calcium 2023, 113: 102762. PMID: 37244172, DOI: 10.1016/j.ceca.2023.102762.Peer-Reviewed Original ResearchConceptsChemotherapy-induced peripheral neuropathyNeuronal calcium sensor-1Chemotherapy-induced cognitive impairmentMultiple chemotherapy regimensChemotherapy-induced neuropathyDisease-modifying treatmentsQuality of lifeChemotherapy regimensChemotherapy dosePeripheral neuropathyPathophysiological cascadePatient outcomesOptimal chemotherapySide effectsCognitive impairmentChemotherapeutic agentsTarget toxicityCancer cellsSensitive CaCalcium signalingOff-target effectsNeuropathyTaxanesTreatmentMolecular mechanisms
2020
Neuronal Calcium Sensor 1 (NCS1) as a Potential Drug Target for Treatment of Wolfram Syndrome
Fischer T, Nguyen L, Ehrlich B. Neuronal Calcium Sensor 1 (NCS1) as a Potential Drug Target for Treatment of Wolfram Syndrome. The FASEB Journal 2020, 34: 1-1. DOI: 10.1096/fasebj.2020.34.s1.00556.Peer-Reviewed Original ResearchNeuronal calcium sensor-1Wolfram syndromeHigh glucose treatmentDiabetes mellitusFunction of WFS1Lack of therapyGlucose treatmentCalcium-dependent protease calpainMajority of casesRat insulinoma cellsBaseline calciumCalcium binding proteinOptical atrophyKO cellsGlucose toxicityCalcium responseCalcium homeostasisPathophysiological consequencesCTRL cellsPhospho-AktDiscovery of drugsPotential drug targetsProtease calpainGenetic causeProtein expression
2010
The prevention of chemotherapy induced peripheral neuropathy by concurrent treatment with drugs used for bipolar disease: a retrospective chart analysis in human cancer patients
Wadia R, Stolar M, Grens C, Ehrlich B, Chao H. The prevention of chemotherapy induced peripheral neuropathy by concurrent treatment with drugs used for bipolar disease: a retrospective chart analysis in human cancer patients. Oncotarget 2010, 5: 2-2. DOI: 10.18632/oncotarget.23441.Peer-Reviewed Original ResearchPeripheral neuropathyNeuronal calcium sensor-1Valproic acidSide effectsBipolar diseaseRetrospective chart review studyDose-limiting side effectChemotherapeutic drugsAltered calcium signalingDevelopment of CIPNPrevention of chemotherapyInitiation of chemotherapyMain dose-limiting side effectChart review studyRetrospective chart analysisVA electronic health recordMajor adverse effectsNumber of patientsDuration of survivalCalcium signalingHuman cancer patientsAberrant calcium signalingQuality of lifeElectronic health recordsApplication of drugs