2023
Calcium signaling in chemotherapy-induced neuropathy
Fonseca M, Marazzi-Diniz P, Leite M, Ehrlich B. Calcium signaling in chemotherapy-induced neuropathy. Cell Calcium 2023, 113: 102762. PMID: 37244172, DOI: 10.1016/j.ceca.2023.102762.Peer-Reviewed Original ResearchConceptsChemotherapy-induced peripheral neuropathyNeuronal calcium sensor-1Chemotherapy-induced cognitive impairmentMultiple chemotherapy regimensChemotherapy-induced neuropathyDisease-modifying treatmentsQuality of lifeChemotherapy regimensChemotherapy dosePeripheral neuropathyPathophysiological cascadePatient outcomesOptimal chemotherapySide effectsCognitive impairmentChemotherapeutic agentsTarget toxicityCancer cellsSensitive CaCalcium signalingOff-target effectsNeuropathyTaxanesTreatmentMolecular mechanisms
2020
Neuroprotective Effects of Lithium in Chemotherapy‐induced Cognitive Impairments
Nguyen L, Fischer T, Ehrlich B. Neuroprotective Effects of Lithium in Chemotherapy‐induced Cognitive Impairments. The FASEB Journal 2020, 34: 1-1. DOI: 10.1096/fasebj.2020.34.s1.00558.Peer-Reviewed Original ResearchCognitive impairmentNeuroprotective effectsChemotherapy-induced cognitive impairmentProtein kinase CPotential neuroprotective effectsGolgi-Cox stainingLife-saving treatmentSpatial memory acquisitionCancer survivorsLast injectionSpine densityCancer patientsNeurological dysfunctionDendritic arborizationIntraperitoneal injectionLithium pretreatmentPaclitaxel injectionMouse modelPaclitaxel treatmentSide effectsCellular deficitsSpecific cognitive functionsNeurodegenerative disordersCognitive functionImpairment
2010
The prevention of chemotherapy induced peripheral neuropathy by concurrent treatment with drugs used for bipolar disease: a retrospective chart analysis in human cancer patients
Wadia R, Stolar M, Grens C, Ehrlich B, Chao H. The prevention of chemotherapy induced peripheral neuropathy by concurrent treatment with drugs used for bipolar disease: a retrospective chart analysis in human cancer patients. Oncotarget 2010, 5: 2-2. DOI: 10.18632/oncotarget.23441.Peer-Reviewed Original ResearchPeripheral neuropathyNeuronal calcium sensor-1Valproic acidSide effectsBipolar diseaseRetrospective chart review studyDose-limiting side effectChemotherapeutic drugsAltered calcium signalingDevelopment of CIPNPrevention of chemotherapyInitiation of chemotherapyMain dose-limiting side effectChart review studyRetrospective chart analysisVA electronic health recordMajor adverse effectsNumber of patientsDuration of survivalCalcium signalingHuman cancer patientsAberrant calcium signalingQuality of lifeElectronic health recordsApplication of drugs
1984
Lithium concentration in the muscle compartment of manic-depressive patients during lithium therapy
Ehrlich B, Clausen C, Gosenfeld L, Diamond J. Lithium concentration in the muscle compartment of manic-depressive patients during lithium therapy. Journal Of Psychiatric Research 1984, 18: 139-148. PMID: 6747912, DOI: 10.1016/0022-3956(84)90005-0.Peer-Reviewed Original ResearchConceptsSide effectsComparison of patientsManic-depressive patientsEffects of lithiumLithium therapyTherapeutic responseRenal excretionPlasma ratioIntestinal absorptionNormal controlsWarrants evaluationMuscle compartmentsTherapyPharmacokinetic techniquesRBC ratioPatientsObserved musclesMuscleBody compartmentsHuman muscleExcitable cellsRBCsExcretionConcentration ratioLithium concentration