2001
Regulation of Ins(1,4,5)P3 receptor isoforms by endogenous modulators
Thrower E, Hagar R, Ehrlich B. Regulation of Ins(1,4,5)P3 receptor isoforms by endogenous modulators. Trends In Pharmacological Sciences 2001, 22: 580-586. PMID: 11698102, DOI: 10.1016/s0165-6147(00)01809-5.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCalcium ChannelsHumansInositol 1,4,5-Trisphosphate ReceptorsPhosphorylationReceptors, Cell SurfaceReceptors, Cytoplasmic and Nuclear
1993
ATP modulates the function of inositol 1,4,5-trisphosphate-gated channels at two sites
Bezprozvanny I, Ehrlich B. ATP modulates the function of inositol 1,4,5-trisphosphate-gated channels at two sites. Neuron 1993, 10: 1175-1184. PMID: 7686381, DOI: 10.1016/0896-6273(93)90065-y.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAnimalsCalciumCalcium ChannelsCerebellumDogsEndoplasmic ReticulumInositol 1,4,5-TrisphosphateInositol 1,4,5-Trisphosphate ReceptorsIon Channel GatingIon ChannelsKineticsLipid BilayersMathematicsMicrosomesModels, NeurologicalReceptors, Cell SurfaceReceptors, Cytoplasmic and NuclearSignal TransductionConceptsPresence of IP3Effect of ATPTrisphosphate-gated channelsIntracellular Ca2Average durationAllosteric modulationSingle-channel levelFunction of inositolIP3 receptorChannel activityCell viabilityReceptorsTrisphosphate receptorIP3Channel openingPermeable channelsCa2ATPInositolAddition of ATPNonhydrolyzable ATP analogChannel conductanceChannel incorporation
1991
Bell-shaped calcium-response curves of lns(l,4,5)P3- and calcium-gated channels from endoplasmic reticulum of cerebellum
Bezprozvanny L, Watras J, Ehrlich B. Bell-shaped calcium-response curves of lns(l,4,5)P3- and calcium-gated channels from endoplasmic reticulum of cerebellum. Nature 1991, 351: 751-754. PMID: 1648178, DOI: 10.1038/351751a0.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAnimalsCalciumCalcium ChannelsCell MembraneCerebellumCytoplasmDogsEndoplasmic ReticulumFeedbackInositol 1,4,5-TrisphosphateInositol 1,4,5-Trisphosphate ReceptorsIon Channel GatingLipid BilayersReceptors, Cell SurfaceReceptors, CholinergicReceptors, Cytoplasmic and NuclearRyanodine Receptor Calcium Release ChannelConceptsCalcium-gated channelsRyanodine receptor/channelEndoplasmic reticulum vesiclesLigand sensitivityEndoplasmic reticulumReceptor/channelCalcium-activated channelChannel typesSame cellsIntracellular calcium regulationCalcium regulationPlanar bilayersCytoplasmic calciumIntracellular storesOpen probabilityCanine cerebellumComplex patternsDifferent responsesAdenine nucleotidesRelease of calciumFunctional propertiesRuthenium redMaximum activityInsP3Cells