1998
Characterization of the ryanodine receptor/channel of invertebrate muscle
Quinn K, Castellani L, Ondrias K, Ehrlich B. Characterization of the ryanodine receptor/channel of invertebrate muscle. American Journal Of Physiology 1998, 274: r494-r502. PMID: 9486309, DOI: 10.1152/ajpregu.1998.274.2.r494.Peer-Reviewed Original ResearchConceptsInvertebrate musclesRyanodine receptor/channelVertebrate skeletal muscleDiverse organismsCalcium release channel/ryanodine receptorRelease channel/ryanodine receptorChannel/ryanodine receptorSingle-channel conductanceReceptor/channelElectron microscopic analysisRyanodine receptorSkeletal muscleRelease channelCytoplasmic Ca2Single-channel currentsSpecific ryanodine bindingChannel conductanceSarcoplasmic reticulumRyRsRuthenium redInvertebratesCa2MammalianRyanodine bindingOrganisms
1997
Methanethiosulfonate Derivatives Inhibit Current through the Ryanodine Receptor/Channel
Quinn K, Ehrlich B. Methanethiosulfonate Derivatives Inhibit Current through the Ryanodine Receptor/Channel. The Journal Of General Physiology 1997, 109: 255-264. PMID: 9041453, PMCID: PMC2220055, DOI: 10.1085/jgp.109.2.255.Peer-Reviewed Original Research
1996
Effects of Rapamycin on Ryanodine Receptor/Ca2+-Release Channels From Cardiac Muscle
Kaftan E, Marks A, Ehrlich B. Effects of Rapamycin on Ryanodine Receptor/Ca2+-Release Channels From Cardiac Muscle. Circulation Research 1996, 78: 990-997. PMID: 8635249, DOI: 10.1161/01.res.78.6.990.Peer-Reviewed Original ResearchConceptsRelease channelFK506-binding proteinCardiac muscleLong-term depressionEffect of rapamycinChannel functionProlyl isomerase activityRelease of Ca2Ryanodine receptor/Ca2Immunosuppressant drugsSkeletal muscle isoformCardiac RyRIsomerase activityRyanodine receptorRapamycinRyRsChannel familyImportant regulatory roleCis-trans peptidylOpen probabilitySubmicromolar concentrationsCell typesDrugsMuscleMuscle isoform
1994
Stabilization of calcium release channel (ryanodine receptor) function by FK506-binding protein
Brillantes A, Ondrias K, Scott A, Kobrinsky E, Ondriašová E, Moschella M, Jayaraman T, Landers M, Ehrlich B, Marks A. Stabilization of calcium release channel (ryanodine receptor) function by FK506-binding protein. Cell 1994, 77: 513-523. PMID: 7514503, DOI: 10.1016/0092-8674(94)90214-3.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCaffeineCalciumCalcium ChannelsCarrier ProteinsCell LineCloning, MolecularGene ExpressionHeat-Shock ProteinsIon Channel GatingIsometric ContractionLipid BilayersMuscle ProteinsPolyenesRabbitsRatsRecombinant ProteinsRNA, MessengerRuthenium RedRyanodineRyanodine Receptor Calcium Release ChannelSarcoplasmic ReticulumSirolimusTacrolimusTacrolimus Binding ProteinsConceptsCellular functionsFK506-binding proteinNatural cellular functionsRelease channel functionInsect cellsProline isomeraseIsomerase activityEndoplasmic reticulumChannel functionFKBP12Channel complexRyanodine receptorCytosolic receptorRelease channel complexRelease channelRapamycinProteinFunctional Ca2Open probabilityCaffeine activationIntracellular Ca2Mean open timeImmunosuppressant drugsCopurifiesReceptors
1991
Comparison of calcium release from sarcoplasmic reticulum of slow and fast twitch muscles
Lee Y, Ondrias K, Duhl A, Ehrlich B, Kim D. Comparison of calcium release from sarcoplasmic reticulum of slow and fast twitch muscles. The Journal Of Membrane Biology 1991, 122: 155-163. PMID: 1716686, DOI: 10.1007/bf01872638.Peer-Reviewed Original ResearchConceptsFast sarcoplasmic reticulumFast-twitch muscleSarcoplasmic reticulumRelease channelSlow sarcoplasmic reticulumTwitch muscleFast musclesSR vesiclesTypes of muscleCalcium releaseMechanism of Ca2MuscleScatchard analysisRyanodine receptorFunctional assaysRuthenium redSingle Ca2Single-channel conductanceOpen probabilityMolecular weight proteinsCa2Closed timeHigh molecular weight proteinsFunctional differences