2024
NCS-1 protein regulates TRPA1 channel through the PI3K pathway in breast cancer and neuronal cells
Sánchez J, Alemán A, Henao J, Olaya J, Ehrlich B. NCS-1 protein regulates TRPA1 channel through the PI3K pathway in breast cancer and neuronal cells. Journal Of Physiology And Biochemistry 2024, 80: 451-463. PMID: 38564162, PMCID: PMC11074019, DOI: 10.1007/s13105-024-01016-z.Peer-Reviewed Original ResearchConceptsTransient receptor potential channel ankyrin 1Breast cancerPI3K pathwayNCS-1Chemotherapy-induced peripheral neuropathyCa2+ channelsK pathwayCa2+ influxNCS-1 expressionBreast cancer cellsCa2+ sensorCa2+ homeostasisCa2+ dynamicsNeuronal calcium sensor-1MDA-MB-231Fura-2Open probabilityPain sensationAnkyrin 1Peripheral neuropathyTRPA1 channelsCo-immunoprecipitationChannel functionRegulatory componentsCellular pathways
2023
Calcium signaling in chemotherapy-induced neuropathy
Fonseca M, Marazzi-Diniz P, Leite M, Ehrlich B. Calcium signaling in chemotherapy-induced neuropathy. Cell Calcium 2023, 113: 102762. PMID: 37244172, DOI: 10.1016/j.ceca.2023.102762.Peer-Reviewed Original ResearchMeSH KeywordsAntineoplastic AgentsCalcium SignalingHumansPeripheral Nervous System DiseasesQuality of LifeConceptsChemotherapy-induced peripheral neuropathyNeuronal calcium sensor-1Chemotherapy-induced cognitive impairmentMultiple chemotherapy regimensChemotherapy-induced neuropathyDisease-modifying treatmentsQuality of lifeChemotherapy regimensChemotherapy dosePeripheral neuropathyPathophysiological cascadePatient outcomesOptimal chemotherapySide effectsCognitive impairmentChemotherapeutic agentsTarget toxicityCancer cellsSensitive CaCalcium signalingOff-target effectsNeuropathyTaxanesTreatmentMolecular mechanisms
2001
Human disease: Calcium signaling in polycystic kidney disease
Somlo S, Ehrlich B. Human disease: Calcium signaling in polycystic kidney disease. Current Biology 2001, 11: r356-r360. PMID: 11369247, DOI: 10.1016/s0960-9822(01)00193-2.Peer-Reviewed Original Research
1998
Type III InsP3 receptor channel stays open in the presence of increased calcium
Hagar R, Burgstahler A, Nathanson M, Ehrlich B. Type III InsP3 receptor channel stays open in the presence of increased calcium. Nature 1998, 396: 81-84. PMID: 9817204, PMCID: PMC2825878, DOI: 10.1038/23954.Peer-Reviewed Original Research