Reversible Block of the Calcium Release Channel/Ryanodine Receptor by Protamine, a Heparin Antidote
Koulen P, Ehrlich B. Reversible Block of the Calcium Release Channel/Ryanodine Receptor by Protamine, a Heparin Antidote. Molecular Biology Of The Cell 2000, 11: 2213-2219. PMID: 10888663, PMCID: PMC14914, DOI: 10.1091/mbc.11.7.2213.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntidotesCalciumCalcium Channel BlockersCell LineChelating AgentsElectrophysiologyHeparin AntagonistsMiceProtaminesRabbitsRyanodine Receptor Calcium Release ChannelConceptsCalcium release channelRyanodine receptorChannel activityIntracellular calcium releaseRelease channelRyanodine receptor activityReceptor type 1Application of protamineMechanism of actionChannel/ryanodine receptorCalcium release channel/ryanodine receptorRelease channel/ryanodine receptorBulk calcium concentrationAddition of heparinRyanodine receptor type 1Single-channel activityReceptor activityCalcium releaseType 1Muscle cellsCalcium concentrationSkeletal muscleHeparin antidoteReversible blockProtamine sulfate