Conservation of localization patterns of IP3 receptor type 1 in cerebellar Purkinje cells across vertebrate species
Koulen P, Janowitz T, Johnston L, Ehrlich B. Conservation of localization patterns of IP3 receptor type 1 in cerebellar Purkinje cells across vertebrate species. Journal Of Neuroscience Research 2000, 61: 493-499. PMID: 10956418, DOI: 10.1002/1097-4547(20000901)61:5<493::aid-jnr3>3.0.co;2-9.Peer-Reviewed Original ResearchConceptsHigh expression levelsVertebrate speciesDifferent vertebrate speciesPhylogenetic developmentNumber of speciesExpression levelsType 1 proteinIP3 receptor type 1Distribution of inositolLocalization patternsMolecular levelPurkinje cellsFluorescence immunocytochemistryCellular levelSpeciesFunctional differencesPolyclonal antiserumAdult cerebellumCerebellar Purkinje cellsReceptor type 1CellsConservationIntracellular calciumOrganismsPurkinje cell dendritesReversible Block of the Calcium Release Channel/Ryanodine Receptor by Protamine, a Heparin Antidote
Koulen P, Ehrlich B. Reversible Block of the Calcium Release Channel/Ryanodine Receptor by Protamine, a Heparin Antidote. Molecular Biology Of The Cell 2000, 11: 2213-2219. PMID: 10888663, PMCID: PMC14914, DOI: 10.1091/mbc.11.7.2213.Peer-Reviewed Original ResearchConceptsCalcium release channelRyanodine receptorChannel activityIntracellular calcium releaseRelease channelRyanodine receptor activityReceptor type 1Application of protamineMechanism of actionChannel/ryanodine receptorCalcium release channel/ryanodine receptorRelease channel/ryanodine receptorBulk calcium concentrationAddition of heparinRyanodine receptor type 1Single-channel activityReceptor activityCalcium releaseType 1Muscle cellsCalcium concentrationSkeletal muscleHeparin antidoteReversible blockProtamine sulfate