2000
Regulation of the Type III InsP3 Receptor by InsP3 and ATP
Hagar R, Ehrlich B. Regulation of the Type III InsP3 Receptor by InsP3 and ATP. Biophysical Journal 2000, 79: 271-278. PMID: 10866953, PMCID: PMC1300931, DOI: 10.1016/s0006-3495(00)76289-8.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAllosteric RegulationAnimalsBinding, CompetitiveCalcium ChannelsDose-Response Relationship, DrugEndoplasmic ReticulumInositol 1,4,5-TrisphosphateInositol 1,4,5-Trisphosphate ReceptorsInsulinomaMicrosomesProtein IsoformsRatsReceptors, Cytoplasmic and NuclearSubstrate SpecificityTumor Cells, CulturedConceptsType IIIChannel activityIntracellular calciumMaximal channel activityATP concentrationProlonged stimulationDependent inhibitionAllosteric modulationInsP3 receptorEnhanced channel activityType IOpen probabilityOpen timeReceptorsHigh ATP concentrationsHigh levelsATPLow ATP concentrationsIsoformsActivity
1998
Type III InsP3 receptor channel stays open in the presence of increased calcium
Hagar R, Burgstahler A, Nathanson M, Ehrlich B. Type III InsP3 receptor channel stays open in the presence of increased calcium. Nature 1998, 396: 81-84. PMID: 9817204, PMCID: PMC2825878, DOI: 10.1038/23954.Peer-Reviewed Original ResearchCharacterization of the ryanodine receptor/channel of invertebrate muscle
Quinn K, Castellani L, Ondrias K, Ehrlich B. Characterization of the ryanodine receptor/channel of invertebrate muscle. American Journal Of Physiology 1998, 274: r494-r502. PMID: 9486309, DOI: 10.1152/ajpregu.1998.274.2.r494.Peer-Reviewed Original ResearchConceptsInvertebrate musclesRyanodine receptor/channelVertebrate skeletal muscleDiverse organismsCalcium release channel/ryanodine receptorRelease channel/ryanodine receptorChannel/ryanodine receptorSingle-channel conductanceReceptor/channelElectron microscopic analysisRyanodine receptorSkeletal muscleRelease channelCytoplasmic Ca2Single-channel currentsSpecific ryanodine bindingChannel conductanceSarcoplasmic reticulumRyRsRuthenium redInvertebratesCa2MammalianRyanodine bindingOrganisms
1993
ATP modulates the function of inositol 1,4,5-trisphosphate-gated channels at two sites
Bezprozvanny I, Ehrlich B. ATP modulates the function of inositol 1,4,5-trisphosphate-gated channels at two sites. Neuron 1993, 10: 1175-1184. PMID: 7686381, DOI: 10.1016/0896-6273(93)90065-y.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAnimalsCalciumCalcium ChannelsCerebellumDogsEndoplasmic ReticulumInositol 1,4,5-TrisphosphateInositol 1,4,5-Trisphosphate ReceptorsIon Channel GatingIon ChannelsKineticsLipid BilayersMathematicsMicrosomesModels, NeurologicalReceptors, Cell SurfaceReceptors, Cytoplasmic and NuclearSignal TransductionConceptsPresence of IP3Effect of ATPTrisphosphate-gated channelsIntracellular Ca2Average durationAllosteric modulationSingle-channel levelFunction of inositolIP3 receptorChannel activityCell viabilityReceptorsTrisphosphate receptorIP3Channel openingPermeable channelsCa2ATPInositolAddition of ATPNonhydrolyzable ATP analogChannel conductanceChannel incorporation
1991
Bell-shaped calcium-response curves of lns(l,4,5)P3- and calcium-gated channels from endoplasmic reticulum of cerebellum
Bezprozvanny L, Watras J, Ehrlich B. Bell-shaped calcium-response curves of lns(l,4,5)P3- and calcium-gated channels from endoplasmic reticulum of cerebellum. Nature 1991, 351: 751-754. PMID: 1648178, DOI: 10.1038/351751a0.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAnimalsCalciumCalcium ChannelsCell MembraneCerebellumCytoplasmDogsEndoplasmic ReticulumFeedbackInositol 1,4,5-TrisphosphateInositol 1,4,5-Trisphosphate ReceptorsIon Channel GatingLipid BilayersReceptors, Cell SurfaceReceptors, CholinergicReceptors, Cytoplasmic and NuclearRyanodine Receptor Calcium Release ChannelConceptsCalcium-gated channelsRyanodine receptor/channelEndoplasmic reticulum vesiclesLigand sensitivityEndoplasmic reticulumReceptor/channelCalcium-activated channelChannel typesSame cellsIntracellular calcium regulationCalcium regulationPlanar bilayersCytoplasmic calciumIntracellular storesOpen probabilityCanine cerebellumComplex patternsDifferent responsesAdenine nucleotidesRelease of calciumFunctional propertiesRuthenium redMaximum activityInsP3Cells