2024
NCS-1 protein regulates TRPA1 channel through the PI3K pathway in breast cancer and neuronal cells
Sánchez J, Alemán A, Henao J, Olaya J, Ehrlich B. NCS-1 protein regulates TRPA1 channel through the PI3K pathway in breast cancer and neuronal cells. Journal Of Physiology And Biochemistry 2024, 80: 451-463. PMID: 38564162, PMCID: PMC11074019, DOI: 10.1007/s13105-024-01016-z.Peer-Reviewed Original ResearchConceptsTransient receptor potential channel ankyrin 1Breast cancerPI3K pathwayNCS-1Chemotherapy-induced peripheral neuropathyCa2+ channelsK pathwayCa2+ influxNCS-1 expressionBreast cancer cellsCa2+ sensorCa2+ homeostasisCa2+ dynamicsNeuronal calcium sensor-1MDA-MB-231Fura-2Open probabilityPain sensationAnkyrin 1Peripheral neuropathyTRPA1 channelsCo-immunoprecipitationChannel functionRegulatory componentsCellular pathways
2023
Response to Kochan et al., 2023
Ehrlich B, Vahdat L, DeCillis A, Seidman A. Response to Kochan et al., 2023. Supportive Care In Cancer 2023, 31: 486. PMID: 37480366, DOI: 10.1007/s00520-023-07950-w.Peer-Reviewed Original ResearchHumansLithiumCalcium signaling in chemotherapy-induced neuropathy
Fonseca M, Marazzi-Diniz P, Leite M, Ehrlich B. Calcium signaling in chemotherapy-induced neuropathy. Cell Calcium 2023, 113: 102762. PMID: 37244172, DOI: 10.1016/j.ceca.2023.102762.Peer-Reviewed Original ResearchConceptsChemotherapy-induced peripheral neuropathyNeuronal calcium sensor-1Chemotherapy-induced cognitive impairmentMultiple chemotherapy regimensChemotherapy-induced neuropathyDisease-modifying treatmentsQuality of lifeChemotherapy regimensChemotherapy dosePeripheral neuropathyPathophysiological cascadePatient outcomesOptimal chemotherapySide effectsCognitive impairmentChemotherapeutic agentsTarget toxicityCancer cellsSensitive CaCalcium signalingOff-target effectsNeuropathyTaxanesTreatmentMolecular mechanisms
2001
Regulation of Ins(1,4,5)P3 receptor isoforms by endogenous modulators
Thrower E, Hagar R, Ehrlich B. Regulation of Ins(1,4,5)P3 receptor isoforms by endogenous modulators. Trends In Pharmacological Sciences 2001, 22: 580-586. PMID: 11698102, DOI: 10.1016/s0165-6147(00)01809-5.Peer-Reviewed Original ResearchHuman disease: Calcium signaling in polycystic kidney disease
Somlo S, Ehrlich B. Human disease: Calcium signaling in polycystic kidney disease. Current Biology 2001, 11: r356-r360. PMID: 11369247, DOI: 10.1016/s0960-9822(01)00193-2.Peer-Reviewed Original Research
1999
Calcium signaling molecules in human cerebellum at midgestation and in ataxia
Zecevic N, Milosevic A, Ehrlich B. Calcium signaling molecules in human cerebellum at midgestation and in ataxia. Early Human Development 1999, 54: 103-116. PMID: 10213289, DOI: 10.1016/s0378-3782(98)00090-5.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBlotting, WesternCadaverCalcium ChannelsCalcium-Binding ProteinsCell DifferentiationCerebellar AtaxiaCerebellumEmbryonic and Fetal DevelopmentHumansImmunohistochemistryInositol 1,4,5-Trisphosphate ReceptorsMicroscopy, FluorescencePurkinje CellsReceptors, Cytoplasmic and NuclearRyanodine Receptor Calcium Release ChannelSynapsesConceptsPurkinje cell layerImmune reactionsIntracellular Ca2Precise topographic connectionsInositol trisphosphate receptor type 1Positive immune reactionHuman cerebellumCell layerReceptor type 1Expression of Ca2Channels/receptorsNeuronal typesAdult brainTrisphosphate receptor type 1Cerebellar cortexDiseased brainTopographic connectionsIntrauterine stagesYounger ageType 1Brain developmentInternal storesImmunocytochemical methodsCerebellumAtaxia
1984
Lithium concentration in the muscle compartment of manic-depressive patients during lithium therapy
Ehrlich B, Clausen C, Gosenfeld L, Diamond J. Lithium concentration in the muscle compartment of manic-depressive patients during lithium therapy. Journal Of Psychiatric Research 1984, 18: 139-148. PMID: 6747912, DOI: 10.1016/0022-3956(84)90005-0.Peer-Reviewed Original ResearchConceptsSide effectsComparison of patientsManic-depressive patientsEffects of lithiumLithium therapyTherapeutic responseRenal excretionPlasma ratioIntestinal absorptionNormal controlsWarrants evaluationMuscle compartmentsTherapyPharmacokinetic techniquesRBC ratioPatientsObserved musclesMuscleBody compartmentsHuman muscleExcitable cellsRBCsExcretionConcentration ratioLithium concentration
1983
Lithium's inhibition of erythrocyte cation countertransport involves a slow process in the erythrocyte
Ehrlich B, Diamond J, Fry V, Meier K. Lithium's inhibition of erythrocyte cation countertransport involves a slow process in the erythrocyte. The Journal Of Membrane Biology 1983, 75: 233-240. PMID: 6631944, DOI: 10.1007/bf01871954.Peer-Reviewed Original ResearchLithium absorption in tight and leaky segments of intestine
Diamond J, Ehrlich B, Morawski S, Santa Ana C, Dordtran J. Lithium absorption in tight and leaky segments of intestine. The Journal Of Membrane Biology 1983, 72: 153-159. PMID: 6854620, DOI: 10.1007/bf01870322.Peer-Reviewed Original Research
1981
Lithium-induced changes in sodium-lithium countertransport
Ehrlich B, Diamond J, Gosenfeld L. Lithium-induced changes in sodium-lithium countertransport. Biochemical Pharmacology 1981, 30: 2539-2543. PMID: 7306206, DOI: 10.1016/0006-2952(81)90580-3.Peer-Reviewed Original ResearchConceptsChronic lithium administrationIntracellular choline concentrationSodium-lithium countertransportLithium-induced changesLithium administrationManic patientsCholine concentrationsInterindividual variationCountertransportInhibitionEffluxDaysErythrocyte membranesPatientsTherapyMichaelis-Menten parameters KmAdministration
1980
Lithium, membranes, and manic-depressive illness
Ehrlich B, Diamond J. Lithium, membranes, and manic-depressive illness. The Journal Of Membrane Biology 1980, 52: 187-200. PMID: 6991708, DOI: 10.1007/bf01869189.Peer-Reviewed Original ResearchAdenylyl CyclasesAnimalsBiological TransportBipolar DisorderBlood-Brain BarrierCalciumCationsChemical PhenomenaChemistryCholineEpitheliumErythrocyte MembraneErythrocytesHumansIntestinal AbsorptionKidneyKineticsLithiumMagnesiumMembrane PotentialsMusclesNeuronsOuabainPotassiumSalivary GlandsSodiumTryptophanLithium pharmacokinetics: Single-dose experiments and analysis using a physiological model
Ehrlich B, Clausen C, Diamond J. Lithium pharmacokinetics: Single-dose experiments and analysis using a physiological model. Journal Of Pharmacokinetics And Pharmacodynamics 1980, 8: 439-461. PMID: 7252790, DOI: 10.1007/bf01059545.Peer-Reviewed Original Research