2024
Neutrophils insert elastase into hepatocytes to regulate calcium signaling in alcohol-associated hepatitis
Ogino N, Leite M, Guerra M, Kruglov E, Asashima H, Hafler D, Ito T, Pereira J, Peiffer B, Sun Z, Ehrlich B, Nathanson M. Neutrophils insert elastase into hepatocytes to regulate calcium signaling in alcohol-associated hepatitis. Journal Of Clinical Investigation 2024, 134: e171691. PMID: 38916955, PMCID: PMC11324315, DOI: 10.1172/jci171691.Peer-Reviewed Original ResearchAlcohol-associated hepatitisReduced cell proliferationCalcium channel expressionCalcium signaling mechanismsIntracellular calcium channelsCell proliferationRegulate calcium signalingNeutrophil extracellular trapsChannel expressionNeutrophil granule proteinsCalcium channelsNeutrophil infiltrationPatient specimensGranule proteasesMouse modelHealthy subjectsLiver diseaseExtracellular trapsCalcium signalingSerpin E2NeutrophilsElastase activityHepatitisTissue remodelingSignaling mechanismsNCS-1 protein regulates TRPA1 channel through the PI3K pathway in breast cancer and neuronal cells
Sánchez J, Alemán A, Henao J, Olaya J, Ehrlich B. NCS-1 protein regulates TRPA1 channel through the PI3K pathway in breast cancer and neuronal cells. Journal Of Physiology And Biochemistry 2024, 80: 451-463. PMID: 38564162, PMCID: PMC11074019, DOI: 10.1007/s13105-024-01016-z.Peer-Reviewed Original ResearchConceptsTransient receptor potential channel ankyrin 1Breast cancerPI3K pathwayNCS-1Chemotherapy-induced peripheral neuropathyCa2+ channelsK pathwayCa2+ influxNCS-1 expressionBreast cancer cellsCa2+ sensorCa2+ homeostasisCa2+ dynamicsNeuronal calcium sensor-1MDA-MB-231Fura-2Open probabilityPain sensationAnkyrin 1Peripheral neuropathyTRPA1 channelsCo-immunoprecipitationChannel functionRegulatory componentsCellular pathwaysAdaptation to mechanical stresses drives an apoptosis-resistant and invasive phenotype in liver cells
Gong X, Ogino N, de Fátima Leite M, Chen Z, Nguyen R, Liu R, Kruglov E, Flores K, Cabral A, de M. Mendes G, Ehrlich B, Mak M. Adaptation to mechanical stresses drives an apoptosis-resistant and invasive phenotype in liver cells. Biophysical Journal 2024, 123: 177a. DOI: 10.1016/j.bpj.2023.11.1163.Peer-Reviewed Original Research
2023
Response to Kochan et al., 2023
Ehrlich B, Vahdat L, DeCillis A, Seidman A. Response to Kochan et al., 2023. Supportive Care In Cancer 2023, 31: 486. PMID: 37480366, DOI: 10.1007/s00520-023-07950-w.Peer-Reviewed Original ResearchCalcium signaling in chemotherapy-induced neuropathy
Fonseca M, Marazzi-Diniz P, Leite M, Ehrlich B. Calcium signaling in chemotherapy-induced neuropathy. Cell Calcium 2023, 113: 102762. PMID: 37244172, DOI: 10.1016/j.ceca.2023.102762.Peer-Reviewed Original ResearchConceptsChemotherapy-induced peripheral neuropathyNeuronal calcium sensor-1Chemotherapy-induced cognitive impairmentMultiple chemotherapy regimensChemotherapy-induced neuropathyDisease-modifying treatmentsQuality of lifeChemotherapy regimensChemotherapy dosePeripheral neuropathyPathophysiological cascadePatient outcomesOptimal chemotherapySide effectsCognitive impairmentChemotherapeutic agentsTarget toxicityCancer cellsSensitive CaCalcium signalingOff-target effectsNeuropathyTaxanesTreatmentMolecular mechanisms
2020
Investigating Polycystin‐2‐mediated mitophagy as a stress response through its role in NAFLD
Brill A, Kuo I, Ehrlich B. Investigating Polycystin‐2‐mediated mitophagy as a stress response through its role in NAFLD. The FASEB Journal 2020, 34: 1-1. DOI: 10.1096/fasebj.2020.34.s1.04144.Peer-Reviewed Original ResearchPolycystin-2PTEN-induced putative kinase 1Mitochondrial functionStress response proteinsPutative kinase 1Endoplasmic reticulum membraneGeneral autophagyAthanogene 2Response proteinsDefective autophagyKinase 1Stress responseBAG2 expressionMitophagyReticulum membraneAberrant dysregulationAutophagyBcl-2High-fat dietSpecific roleMurine liverHaploinsufficient miceProteinBAG2Ca 2Neuronal Calcium Sensor 1 (NCS1) as a Potential Drug Target for Treatment of Wolfram Syndrome
Fischer T, Nguyen L, Ehrlich B. Neuronal Calcium Sensor 1 (NCS1) as a Potential Drug Target for Treatment of Wolfram Syndrome. The FASEB Journal 2020, 34: 1-1. DOI: 10.1096/fasebj.2020.34.s1.00556.Peer-Reviewed Original ResearchNeuronal calcium sensor-1Wolfram syndromeHigh glucose treatmentDiabetes mellitusFunction of WFS1Lack of therapyGlucose treatmentCalcium-dependent protease calpainMajority of casesRat insulinoma cellsBaseline calciumCalcium binding proteinOptical atrophyKO cellsGlucose toxicityCalcium responseCalcium homeostasisPathophysiological consequencesCTRL cellsPhospho-AktDiscovery of drugsPotential drug targetsProtease calpainGenetic causeProtein expressionNeuroprotective Effects of Lithium in Chemotherapy‐induced Cognitive Impairments
Nguyen L, Fischer T, Ehrlich B. Neuroprotective Effects of Lithium in Chemotherapy‐induced Cognitive Impairments. The FASEB Journal 2020, 34: 1-1. DOI: 10.1096/fasebj.2020.34.s1.00558.Peer-Reviewed Original ResearchCognitive impairmentNeuroprotective effectsChemotherapy-induced cognitive impairmentProtein kinase CPotential neuroprotective effectsGolgi-Cox stainingLife-saving treatmentSpatial memory acquisitionCancer survivorsLast injectionSpine densityCancer patientsNeurological dysfunctionDendritic arborizationIntraperitoneal injectionLithium pretreatmentPaclitaxel injectionMouse modelPaclitaxel treatmentSide effectsCellular deficitsSpecific cognitive functionsNeurodegenerative disordersCognitive functionImpairment
2018
Mechanisms by Which Glucagon Acutely Stimulates Hepatic Mitochondrial Oxidation and Gluconeogenesis
PERRY R, WANG Y, BRILL A, PENG L, ZHANG D, DUFOUR S, ZHANG Y, ZHANG X, NOZAKI Y, CLINE G, EHRLICH B, PETERSEN K, SHULMAN G. Mechanisms by Which Glucagon Acutely Stimulates Hepatic Mitochondrial Oxidation and Gluconeogenesis. Diabetes 2018, 67 DOI: 10.2337/db18-146-or.Peer-Reviewed Original ResearchSpouse/partnerHigh-fat diet-induced hepatic steatosisNonalcoholic fatty liver diseaseDiet-induced hepatic steatosisGilead SciencesFatty liver diseasePlasma glucagon concentrationsType 2 diabetesHepatic acetyl-CoA contentLiver-specific knockdownIntracellular calcium signalingMitochondrial oxidationGlucose intoleranceAdipocyte triglyceride lipaseLiver diseaseWT miceGlucagon concentrationsHepatic steatosisGlucagon infusionAcetyl-CoA contentChronic increaseHepatic mitochondrial oxidationGlucagon biologyGlucagon stimulationKnockout miceRole of the mechanosensitive ion channel Piezo1 in Autosomal Dominant Polycystic Kidney Disease (ADPKD)
Chebib F, Beyder A, Wang X, Alcaino C, Ehrlich B, Torres V. Role of the mechanosensitive ion channel Piezo1 in Autosomal Dominant Polycystic Kidney Disease (ADPKD). The FASEB Journal 2018, 32: 868.2-868.2. DOI: 10.1096/fasebj.2018.32.1_supplement.868.2.Peer-Reviewed Original ResearchAutosomal dominant polycystic kidney diseaseCalcium entryCyclic AMPMIMCD3 cellsCytoplasmic calciumFluid shear stressWild-type miceDominant polycystic kidney diseaseRenal cystogenesisFull-text articlesNon-selective cation channelsPolycystic kidney diseaseKidney diseaseExperimental Biology 2018 MeetingIntracellular calciumType miceVivo effectsPathogenic mechanismsCystic epitheliumLive-cell imagingMechanosensitive ion channelsSecretory phenotypeATP releaseMechanosensitive ion channel Piezo1Cation channels
2015
Persistent cAMP Signaling via Vasopressin V2 Receptors Imaged in 3D Cultures Using Lightsheet Microscopy
Jiang J, Kuo I, Abi‐Jaoude J, Lemos F, Yang Y, Curci S, Ehrlich B, Hofer A. Persistent cAMP Signaling via Vasopressin V2 Receptors Imaged in 3D Cultures Using Lightsheet Microscopy. The FASEB Journal 2015, 29 DOI: 10.1096/fasebj.29.1_supplement.lb632.Peer-Reviewed Original ResearchCharacterization of PC2 Cterm Calcium-Binding Interaction and its Structural Implications
Yang Y, Keeler C, Kuo I, Lolis E, Hodsdon M, Ehrlich B. Characterization of PC2 Cterm Calcium-Binding Interaction and its Structural Implications. Biophysical Journal 2015, 108: 215a. DOI: 10.1016/j.bpj.2014.11.1186.Peer-Reviewed Original Research
2010
The prevention of chemotherapy induced peripheral neuropathy by concurrent treatment with drugs used for bipolar disease: a retrospective chart analysis in human cancer patients
Wadia R, Stolar M, Grens C, Ehrlich B, Chao H. The prevention of chemotherapy induced peripheral neuropathy by concurrent treatment with drugs used for bipolar disease: a retrospective chart analysis in human cancer patients. Oncotarget 2010, 5: 2-2. DOI: 10.18632/oncotarget.23441.Peer-Reviewed Original ResearchPeripheral neuropathyNeuronal calcium sensor-1Valproic acidSide effectsBipolar diseaseRetrospective chart review studyDose-limiting side effectChemotherapeutic drugsAltered calcium signalingDevelopment of CIPNPrevention of chemotherapyInitiation of chemotherapyMain dose-limiting side effectChart review studyRetrospective chart analysisVA electronic health recordMajor adverse effectsNumber of patientsDuration of survivalCalcium signalingHuman cancer patientsAberrant calcium signalingQuality of lifeElectronic health recordsApplication of drugsPolycystin-2 Contains an Unpaired EF-hand Motif which May Serve as a Ca2+-Sensitive Regulator of Polycystin-2 Channel Activity
Celic A, Petri E, Hodsdon M, Boggon T, Ehrlich B. Polycystin-2 Contains an Unpaired EF-hand Motif which May Serve as a Ca2+-Sensitive Regulator of Polycystin-2 Channel Activity. Biophysical Journal 2010, 98: 532a-533a. DOI: 10.1016/j.bpj.2009.12.2890.Peer-Reviewed Original Research
2009
The Amplification Of InsP3R Activity By NCS-1 Is Attenuated By Medications Used In The Treatment Of Bipolar Disorder
Schulze C, Olofsson J, Ehrlich B. The Amplification Of InsP3R Activity By NCS-1 Is Attenuated By Medications Used In The Treatment Of Bipolar Disorder. Biophysical Journal 2009, 96: 96a. DOI: 10.1016/j.bpj.2008.12.407.Peer-Reviewed Original ResearchRegulation Of Inositol 1,4,5-Trisphosphate Receptor Isoforms By O-Linked Glycosylation
Bimboese P, Gibson C, Schmidt S, Paavola J, Ehrlich B. Regulation Of Inositol 1,4,5-Trisphosphate Receptor Isoforms By O-Linked Glycosylation. Biophysical Journal 2009, 96: 97a-98a. DOI: 10.1016/j.bpj.2008.12.412.Peer-Reviewed Original ResearchA C-terminal Fragment of Chromogranin B Amplifies Inostiol (1,4,5)-Trisphohsphate Receptor Mediated Signaling
Schmidt S, Heidrich F, Mo M, Ehrlich B. A C-terminal Fragment of Chromogranin B Amplifies Inostiol (1,4,5)-Trisphohsphate Receptor Mediated Signaling. Biophysical Journal 2009, 96: 97a. DOI: 10.1016/j.bpj.2008.12.409.Peer-Reviewed Original ResearchDiscrete Proteolysis Of Neuronal Calcium Sensor 1 By μ-calpain Disrupts Calcium Binding
Blachford C, Celic A, Petri E, Ehrlich B. Discrete Proteolysis Of Neuronal Calcium Sensor 1 By μ-calpain Disrupts Calcium Binding. Biophysical Journal 2009, 96: 121a. DOI: 10.1016/j.bpj.2008.12.534.Peer-Reviewed Original ResearchCalcium Induced Conformational Changes In The Cytoplasmic Tail Of Polycystin-2
Petri E, Celic A, Boggon T, Ehrlich B. Calcium Induced Conformational Changes In The Cytoplasmic Tail Of Polycystin-2. Biophysical Journal 2009, 96: 119a. DOI: 10.1016/j.bpj.2008.12.526.Peer-Reviewed Original Research
2006
Corrigendum to “Calcium release from ryanodine receptors in the nucleoplasmic reticulum” [Cell Calcium 39 (2006) 65–73]
Marius P, Guerra M, Nathanson M, Ehrlich B, Leite M. Corrigendum to “Calcium release from ryanodine receptors in the nucleoplasmic reticulum” [Cell Calcium 39 (2006) 65–73]. Cell Calcium 2006, 39: 551. DOI: 10.1016/j.ceca.2006.02.001.Peer-Reviewed Original Research