2022
Noxious Combination of Tobacco Smoke Nitrosamines with Bile, Deoxycholic Acid, Promotes Hypopharyngeal Squamous Cell Carcinoma, via NFκB, In Vivo.
Vageli DP, Doukas PG, Doukas SG, Tsatsakis A, Judson BL. Noxious Combination of Tobacco Smoke Nitrosamines with Bile, Deoxycholic Acid, Promotes Hypopharyngeal Squamous Cell Carcinoma, via NFκB, In Vivo. Cancer Prevention Research 2022, 15: 297-308. PMID: 35502554, DOI: 10.1158/1940-6207.capr-21-0529.Peer-Reviewed Original ResearchConceptsHypopharyngeal squamous cell carcinomaTobacco smoke componentsSquamous cell carcinomaAerodigestive tract carcinogenesisBile refluxRisk factorsHypopharyngeal cancerCell carcinomaChronic exposureNFκB activationVivo modelUpper aerodigestive tract cancerNoxious combinationLarge-scale studiesIndependent risk factorAerodigestive tract cancerUpper aerodigestive tract carcinogenesisHigh-risk individualsVivo chronic exposurePresence of bileSilent progressionTract cancerTobacco smokingInvasive carcinomaPremalignant lesions
2021
Bile reflux and hypopharyngeal cancer
Vageli DP, Doukas SG, Doukas PG, Judson BL. Bile reflux and hypopharyngeal cancer. Oncology Reports 2021, 46: 244. PMID: 34558652, PMCID: PMC8485019, DOI: 10.3892/or.2021.8195.Peer-Reviewed Original ResearchConceptsHypopharyngeal cancerAcidic bileHypopharyngeal carcinogenesisBile refluxRisk factorsGastroesophageal reflux diseaseIndependent risk factorSquamous cell cancerUpper aerodigestive tractElevated p53 expressionAnti-apoptotic effectsReflux diseaseLaryngopharyngeal refluxAerodigestive tractCell cancerGastroesophageal refluxateContribution of STAT3Neck cancerPrecancerous lesionsPremalignant changesNeoplastic changesNF-κBDNA damageP53 expressionBile acids
2014
Safety of Adult Tonsillectomy: A Population-Level Analysis of 5968 Patients
Chen MM, Roman SA, Sosa JA, Judson BL. Safety of Adult Tonsillectomy: A Population-Level Analysis of 5968 Patients. JAMA Otolaryngology - Head & Neck Surgery 2014, 140: 197-202. PMID: 24481159, DOI: 10.1001/jamaoto.2013.6215.Peer-Reviewed Original ResearchConceptsAdult tonsillectomyPostoperative complicationsReoperation rateSurgeons National Surgical Quality Improvement ProgramNational Surgical Quality Improvement ProgramSurgical Quality Improvement ProgramSuperficial site infectionRetrospective cohort studyIndependent risk factorUrinary tract infectionSmall case seriesMultivariate logistic regressionOutcomes of interestPopulation-level analysisQuality Improvement ProgramFirst population-level analysisChronic tonsillitisAdult patientsCohort studyCommon complicationComplication rateMost patientsPostoperative periodTract infectionsSite infection