2019
Clinical characteristics and treatment‐associated survival of head and neck Ewing sarcoma
Torabi SJ, Izreig S, Kasle DA, Benchetrit L, Salehi PP, Judson BL. Clinical characteristics and treatment‐associated survival of head and neck Ewing sarcoma. The Laryngoscope 2019, 130: 2385-2392. PMID: 31774563, DOI: 10.1002/lary.28412.Peer-Reviewed Original ResearchConceptsNational Cancer DatabaseOverall survivalLocal therapyRare malignancySurvival analysisPredictors of OSKaplan-Meier survival analysisNeck Ewing sarcomaDistant metastatic diseaseNon-metastatic diseaseMultivariate Cox regressionTime of diagnosisTime of presentationMulti-modal therapyWorse OSClinical characteristicsMetastatic diseaseImproved survivalPediatric patientsDistant metastasisCox regressionRetrospective studyAnatomic distributionCancer DatabaseOsseous disease
2018
Survival Outcomes for Induction vs Adjuvant Chemotherapy in Squamous Cell Carcinoma of the Maxillary Sinus
Kuo P, Torabi SJ, Kraus D, Judson BL. Survival Outcomes for Induction vs Adjuvant Chemotherapy in Squamous Cell Carcinoma of the Maxillary Sinus. Otolaryngology 2018, 160: 658-663. PMID: 30296902, DOI: 10.1177/0194599818804777.Peer-Reviewed Original ResearchConceptsNational Cancer DatabaseAdjuvant chemotherapyMultivariate Cox regressionInduction chemotherapyLog-rank testMaxillary sinus cancerOverall survivalCox regressionSinus cancerMaxillary sinusUnivariate Kaplan-Meier analysisPoor local control ratesAdvanced maxillary sinus cancerAdjuvant chemotherapy cohortImproved overall survivalLocal control rateMortality hazard ratioKaplan-Meier analysisSquamous cell carcinomaSignificant mortality hazard ratiosSecondary database analysisWarrants further investigationPropensity-score matchingChemotherapy cohortHazard ratio
2017
Treatment deintensification in human papillomavirus‐positive oropharynx cancer: Outcomes from the National Cancer Data Base
Cheraghlou S, Yu PK, Otremba MD, Park HS, Bhatia A, Zogg CK, Mehra S, Yarbrough WG, Judson BL. Treatment deintensification in human papillomavirus‐positive oropharynx cancer: Outcomes from the National Cancer Data Base. Cancer 2017, 124: 717-726. PMID: 29243245, DOI: 10.1002/cncr.31104.Peer-Reviewed Original ResearchConceptsNational Cancer Data BaseStage III diseaseTriple-modality therapyAdjuvant radiotherapyOropharyngeal cancerStage IHuman papillomavirus-positive oropharyngeal cancerUnivariate Kaplan-Meier analysisAvoidance of chemotherapyDeintensification of treatmentEdition stage IStage II diseaseMultivariate Cox regressionAmerican Joint CommitteeKaplan-Meier analysisDisease stage groupsForm of treatmentTreatment deintensificationAdjuvant chemoradiotherapyDefinitive radiotherapyTreatment intensificationFavorable prognosisImproved survivalCox regressionRetrospective studyUntreated oral cavity cancer: Long‐term survival and factors associated with treatment refusal
Cheraghlou S, Kuo P, Mehra S, Yarbrough WG, Judson BL. Untreated oral cavity cancer: Long‐term survival and factors associated with treatment refusal. The Laryngoscope 2017, 128: 664-669. PMID: 28865100, DOI: 10.1002/lary.26809.Peer-Reviewed Original ResearchConceptsOral cavity cancerNatural courseTreatment refusalUnivariate Kaplan-Meier analysisFive-year survival rateFacility case volumeNational Cancer DatabaseStage 4 patientsExtent of diseaseMultivariate Cox regressionEarly-stage patientsKaplan-Meier analysisNumber of patientsCommon malignant diseaseLong-term survivalInitial treatment planningAdvanced diseaseUntreated patientsAdult patientsRetrospective reviewCox regressionPatient's likelihoodPoor prognosisInsurance statusMalignant disease
2016
Survival Outcomes for Combined Modality Therapy for Sinonasal Undifferentiated Carcinoma
Kuo P, Manes RP, Schwam ZG, Judson BL. Survival Outcomes for Combined Modality Therapy for Sinonasal Undifferentiated Carcinoma. Otolaryngology 2016, 156: 132-136. PMID: 27703092, DOI: 10.1177/0194599816670146.Peer-Reviewed Original ResearchConceptsSinonasal undifferentiated carcinomaCombined modality therapyNational Cancer DatabaseUndifferentiated carcinomaChemoradiotherapy groupModality therapyOverall survivalSurvival outcomesTreatment modalitiesCancer DatabaseSurvival rateAdjuvant chemotherapy groupImproved survival outcomesMultivariate Cox regressionCumulative survival rateKaplan-Meier analysisMulti-institutional studyCases of SNUCAdjuvant chemotherapyChemotherapy groupMultimodality therapyModality treatmentPrognostic factorsCox regressionAggressive malignancyTreatment delay and facility case volume are associated with survival in early‐stage glottic cancer
Cheraghlou S, Kuo P, Judson BL. Treatment delay and facility case volume are associated with survival in early‐stage glottic cancer. The Laryngoscope 2016, 127: 616-622. PMID: 27653749, DOI: 10.1002/lary.26259.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAntineoplastic Combined Chemotherapy ProtocolsCohort StudiesCombined Modality TherapyDisease-Free SurvivalEarly Detection of CancerFemaleGlottisHospitals, High-VolumeHumansKaplan-Meier EstimateLaryngeal NeoplasmsLaryngectomyMaleMiddle AgedOrgan Sparing TreatmentsProportional Hazards ModelsRadiotherapy, AdjuvantRetrospective StudiesRisk AssessmentSurvival AnalysisTime FactorsWaiting ListsConceptsEarly-stage glottic cancerGlottic cancerUnivariate Kaplan-Meier analysisSystem factorsFacility case volumeNational Cancer DatabaseMultivariate Cox regressionEarly glottic cancerKaplan-Meier analysisImprovement of outcomesTumor factorsAdult patientsWorse survivalImproved survivalNumber of treatmentsRetrospective studyTreatment delayCox regressionCancer DatabaseCase volumeGovernment insurancePatientsCancerTreatment factorsSurvival variables