2022
The Effect of Tobacco Smoke N-Nitrosamines, NNK and NDEA, and Nicotine, on DNA Mismatch Repair Mechanism and miRNA Markers, in Hypopharyngeal Squamous Cell Carcinoma: An In Vivo Model and Clinical Evidence
Doukas SG, Vageli DP, Doukas PG, Nikitovic D, Tsatsakis A, Judson BL. The Effect of Tobacco Smoke N-Nitrosamines, NNK and NDEA, and Nicotine, on DNA Mismatch Repair Mechanism and miRNA Markers, in Hypopharyngeal Squamous Cell Carcinoma: An In Vivo Model and Clinical Evidence. Current Oncology 2022, 29: 5531-5549. PMID: 36005175, PMCID: PMC9406897, DOI: 10.3390/curroncol29080437.Peer-Reviewed Original ResearchConceptsHypopharyngeal squamous cell carcinomaSquamous cell carcinomaClinical evidenceCell carcinomaTobacco smokeChronic exposureUpper aerodigestive tract cancerHuman hypopharyngeal squamous cell carcinomaAerodigestive tract cancerUpper aerodigestive tract carcinogenesisAerodigestive tract carcinogenesisDose-dependent effectDNA mismatch repair mechanismHypopharyngeal cellsTract cancerTobacco smokersPoor prognosisHypopharyngeal mucosaMouse modelClinical testingVivo modelMiR-155MiR-451aVivo dose-dependent effectMismatch repair mechanism
2018
Adjuvant Chemotherapy Is Associated With Improved Survival for Late‐Stage Salivary Squamous Cell Carcinoma
Cheraghlou S, Schettino A, Zogg CK, Otremba MD, Bhatia A, Park HS, Osborn HA, Mehra S, Yarbrough WG, Judson BL. Adjuvant Chemotherapy Is Associated With Improved Survival for Late‐Stage Salivary Squamous Cell Carcinoma. The Laryngoscope 2018, 129: 883-889. PMID: 30151947, DOI: 10.1002/lary.27444.Peer-Reviewed Original ResearchMeSH KeywordsAgedCarcinoma, Squamous CellChemoradiotherapy, AdjuvantChemotherapy, AdjuvantCombined Modality TherapyFemaleHumansKaplan-Meier EstimateMaleMiddle AgedNeoplasm StagingPropensity ScoreProportional Hazards ModelsRadiotherapy, AdjuvantRetrospective StudiesSalivary Gland NeoplasmsSurvival RateTreatment OutcomeConceptsLate-stage patientsSquamous cell carcinomaAdjuvant radiotherapyAdjuvant therapyAdjuvant chemoradiotherapyAdjuvant chemotherapyImproved survivalCell carcinomaImproved long-term survivalCox survival regressionPrimary cutaneous malignanciesUnique disease entityAddition of chemotherapyNational Cancer DatabaseEarly-stage diseaseFive-year survivalEarly-stage patientsKaplan-Meier analysisParotid gland cancerLate stage groupLong-term survivalSurvival benefitCutaneous malignanciesPoor prognosisRetrospective study
2017
The cancer-testis antigen, sperm protein 17, a new biomarker and immunological target in head and neck squamous cell carcinoma
Schutt CA, Mirandola L, Figueroa JA, Nguyen DD, Cordero J, Bumm K, Judson BL, Chiriva-Internati M. The cancer-testis antigen, sperm protein 17, a new biomarker and immunological target in head and neck squamous cell carcinoma. Oncotarget 2017, 5: 100280-100287. PMID: 29245977, PMCID: PMC5725019, DOI: 10.18632/oncotarget.22213.Peer-Reviewed Original ResearchNeck squamous cell carcinomaAutologous dendritic cellsAutologous tumor cellsSquamous cell carcinomaHNSCC patientsCancer-testis antigensDendritic cellsCell carcinomaNon-small cell lung cancerTumor cellsSp17 expressionIdeal immunotherapeutic targetSpecific cytotoxic lymphocytesCell lung cancerCurrent treatment modalitiesPotential serological biomarkerSperm protein 17Possible future targetsTherapeutic vaccinesImmunotherapeutic targetPoor prognosisAggressive malignancyMultiple myelomaPeripheral bloodTNM stageUntreated oral cavity cancer: Long‐term survival and factors associated with treatment refusal
Cheraghlou S, Kuo P, Mehra S, Yarbrough WG, Judson BL. Untreated oral cavity cancer: Long‐term survival and factors associated with treatment refusal. The Laryngoscope 2017, 128: 664-669. PMID: 28865100, DOI: 10.1002/lary.26809.Peer-Reviewed Original ResearchConceptsOral cavity cancerNatural courseTreatment refusalUnivariate Kaplan-Meier analysisFive-year survival rateFacility case volumeNational Cancer DatabaseStage 4 patientsExtent of diseaseMultivariate Cox regressionEarly-stage patientsKaplan-Meier analysisNumber of patientsCommon malignant diseaseLong-term survivalInitial treatment planningAdvanced diseaseUntreated patientsAdult patientsRetrospective reviewCox regressionPatient's likelihoodPoor prognosisInsurance statusMalignant disease
2014
Predictors of survival in carcinoma ex pleomorphic adenoma
Chen MM, Roman SA, Sosa JA, Judson BL. Predictors of survival in carcinoma ex pleomorphic adenoma. Head & Neck 2014, 36: 1324-1328. PMID: 23956034, DOI: 10.1002/hed.23453.Peer-Reviewed Original ResearchConceptsDisease-specific survivalCervical lymph node metastasisLymph node metastasisCa ex-PAPleomorphic adenomaLymph nodesNode metastasisMultiple cervical lymph node metastasesMultiple metastatic lymph nodesPositive lymph nodesEnd Results (SEER) databaseMetastatic lymph nodesPredictors of survivalHigh-grade carcinomaCarcinoma ex pleomorphic adenomaEx pleomorphic adenomaFirst population-level analysisBenign pleomorphic adenomaExtraparenchymal extensionCervical metastasisIndependent predictorsDistant metastasisPrognostic featuresResults databasePoor prognosisPrognostic factors for squamous cell cancer of the parotid gland: An analysis of 2104 patients
Chen MM, Roman SA, Sosa JA, Judson BL. Prognostic factors for squamous cell cancer of the parotid gland: An analysis of 2104 patients. Head & Neck 2014, 37: 1-7. PMID: 24339135, DOI: 10.1002/hed.23566.Peer-Reviewed Original ResearchConceptsSquamous cell cancerCell cancerRadiation therapyCutaneous squamous cell cancerCommon parotid malignancyAdjuvant radiation therapyDisease-specific mortalityDisease-specific survivalEnd Results (SEER) databaseYears of ageExtraparenchymal extensionCervical metastasisParotid malignanciesAdult patientsPrimary malignancyImproved survivalPrognostic factorsDistant metastasisResults databasePoor prognosisTumor sizeTreatment outcomesParotid glandPatientsSurgery