2020
Revisiting the Radiation Therapy Oncology Group 1221 Hypothesis: Treatment for Stage III/IV HPV-Negative Oropharyngeal Cancer
Jacobs D, Torabi SJ, Park HS, Rahmati R, Young MR, Mehra S, Judson BL. Revisiting the Radiation Therapy Oncology Group 1221 Hypothesis: Treatment for Stage III/IV HPV-Negative Oropharyngeal Cancer. Otolaryngology 2020, 164: 1240-1248. PMID: 33198564, DOI: 10.1177/0194599820969613.Peer-Reviewed Original ResearchConceptsNational Cancer DatabaseHPV-negative oropharyngeal cancersChemoradiation therapyOverall survivalCancer DatabaseOropharyngeal cancerHPV-negative oropharyngeal squamous cell carcinomaLarge national cancer databaseNeck cancer-specific survivalOropharyngeal squamous cell carcinomaCox proportional hazards regressionKaplan-Meier survival analysisCancer-specific survivalImproved overall survivalMultivariable Cox regressionRetrospective cohort studyAdjuvant chemoradiation therapyUse of surgeryEnd Results ProgramProportional hazards regressionSquamous cell carcinomaSEER cohortAdjuvant therapyCohort studySEER database
2018
Sex differences in patients with high risk HPV-associated and HPV negative oropharyngeal and oral cavity squamous cell carcinomas
Li H, Park HS, Osborn HA, Judson BL. Sex differences in patients with high risk HPV-associated and HPV negative oropharyngeal and oral cavity squamous cell carcinomas. Cancers Of The Head & Neck 2018, 3: 4. PMID: 31093357, PMCID: PMC6460664, DOI: 10.1186/s41199-018-0031-y.Peer-Reviewed Original ResearchSquamous cell carcinomaNational Cancer DatabaseOverall survivalOral cavityHPV cancersCell carcinomaHPV-negative squamous cell carcinomaOral cavity squamous cell carcinomaOP SCCHigh-risk human papillomavirusImproved overall survivalRetrospective cohort studyHigh-risk HPVDistinct clinical entityHuman papilloma virusLog-rank testKaplan-Meier estimatesOral cavity sitesChi-square testHPV carcinogenesisWorse OSCohort studyHPV statusRisk HPVClinical entity
2017
Thirty‐day morbidity and mortality following otologic/neurotologic surgery: Analysis of the national surgical quality improvement program
Schwam ZG, Michaelides E, Kuo P, Hajek MA, Judson BL, Schutt C. Thirty‐day morbidity and mortality following otologic/neurotologic surgery: Analysis of the national surgical quality improvement program. The Laryngoscope 2017, 128: 1431-1437. PMID: 28940480, DOI: 10.1002/lary.26848.Peer-Reviewed Original ResearchConceptsNational Surgical Quality Improvement ProgramSurgical Quality Improvement ProgramAdverse event ratesQuality Improvement ProgramPostoperative morbidityFunctional statusTumor resectionNeurotologic surgerySurgeons National Surgical Quality Improvement ProgramOpen woundsOverall adverse event rateEvent ratesHigher adverse event ratesThirty-day morbidityPoor functional statusRetrospective cohort studyOverall mortality rateMultivariable logistic regressionImpaired functional statusMastoid proceduresPostoperative mortalityMajor morbidityPostoperative complicationsSignificant comorbiditiesCohort study
2016
Receipt of Care Discordant with Practice Guidelines is Associated with Compromised Overall Survival in Nasopharyngeal Carcinoma
Schwam ZG, Sosa JA, Roman S, Judson BL. Receipt of Care Discordant with Practice Guidelines is Associated with Compromised Overall Survival in Nasopharyngeal Carcinoma. Clinical Oncology 2016, 28: 402-409. PMID: 26868285, DOI: 10.1016/j.clon.2016.01.010.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overCarcinomaChemoradiotherapyFemaleGuideline AdherenceHumansMaleMiddle AgedNasopharyngeal CarcinomaNasopharyngeal NeoplasmsNeoplasm StagingPractice Guidelines as TopicPrognosisProportional Hazards ModelsRetrospective StudiesRisk FactorsStandard of CareSurvival RateYoung AdultConceptsGuideline-discordant carePractice guidelinesOverall survivalNasopharyngeal carcinomaStage INational Comprehensive Cancer Network guidelinesNational Cancer Data BaseNational treatment patternsRetrospective cohort studyNasopharyngeal carcinoma patientsRisk of deathStage IVC diseaseChemoradiation therapyCohort studyCarcinoma patientsImproved survivalMultivariable logisticMultivariable analysisTreatment patternsCox regressionIVC diseaseNetwork guidelinesTreatment regimensKaplan-MeierPatients
2015
Improved prognosis for patients with oral cavity squamous cell carcinoma: Analysis of the National Cancer Database 1998–2006
Schwam ZG, Judson BL. Improved prognosis for patients with oral cavity squamous cell carcinoma: Analysis of the National Cancer Database 1998–2006. Oral Oncology 2015, 52: 45-51. PMID: 26553389, DOI: 10.1016/j.oraloncology.2015.10.012.Peer-Reviewed Original ResearchConceptsOral cavity squamous cell carcinomaLate-stage diseaseThree-year overall survivalEarly-stage diseaseEarly-stage patientsStage diseaseSquamous cell carcinomaStage patientsNeck dissectionOverall survivalCell carcinomaObserved survival improvementNational Cancer DatabaseRetrospective cohort studyHigh-volume centersNegative surgical marginsAdvanced-stage patientsLarge administrative databaseAdjuvant chemoradiationOCSCC patientsAdjuvant therapyCohort studyImproved survivalSurgical marginsSurvival improvementComplications and mortality following surgery for oral cavity cancer: Analysis of 408 cases
Schwam ZG, Sosa JA, Roman S, Judson BL. Complications and mortality following surgery for oral cavity cancer: Analysis of 408 cases. The Laryngoscope 2015, 125: 1869-1873. PMID: 26063059, DOI: 10.1002/lary.25328.Peer-Reviewed Original ResearchConceptsOral cavity cancerPostdischarge complicationsPostoperative complicationsNeck dissectionNational Surgical Quality Improvement Program Participant Use Data FilesSurgeons National Surgical Quality Improvement Program Participant Use Data FilesSurgical siteDay 14Oral cavity cancer surgeryParticipant Use Data FilePostdischarge surgical-site infectionsCommon adverse eventsRetrospective cohort studySurgical site complicationsHigh-risk patientsModifiable risk factorsSurgical site infectionDisease-specific complicationsMultivariate regression analysisRespiratory complicationsAdverse eventsCohort studyCurrent smokersSite complicationsCancer surgery
2014
Hypopharyngeal cancer incidence, treatment, and survival: Temporal trends in the United States
Kuo P, Chen MM, Decker RH, Yarbrough WG, Judson BL. Hypopharyngeal cancer incidence, treatment, and survival: Temporal trends in the United States. The Laryngoscope 2014, 124: 2064-2069. PMID: 25295351, DOI: 10.1002/lary.24651.Peer-Reviewed Original ResearchConceptsAverage annual percent changeHypopharyngeal cancerPatient demographicsTreatment modalitiesDisease severityEnd Results (SEER) databaseRetrospective cohort studyKaplan-Meier analysisAnnual percent changeAdult patientsCohort studyOverall survivalWorse survivalImproved survivalResults databaseT stageTumor characteristicsCox regressionCancer incidenceMultivariate analysisPercent changeLaryngopharyngectomyCancerIncidenceTemporal trendsSafety of Adult Tonsillectomy: A Population-Level Analysis of 5968 Patients
Chen MM, Roman SA, Sosa JA, Judson BL. Safety of Adult Tonsillectomy: A Population-Level Analysis of 5968 Patients. JAMA Otolaryngology - Head & Neck Surgery 2014, 140: 197-202. PMID: 24481159, DOI: 10.1001/jamaoto.2013.6215.Peer-Reviewed Original ResearchConceptsAdult tonsillectomyPostoperative complicationsReoperation rateSurgeons National Surgical Quality Improvement ProgramNational Surgical Quality Improvement ProgramSurgical Quality Improvement ProgramSuperficial site infectionRetrospective cohort studyIndependent risk factorUrinary tract infectionSmall case seriesMultivariate logistic regressionOutcomes of interestPopulation-level analysisQuality Improvement ProgramFirst population-level analysisChronic tonsillitisAdult patientsCohort studyCommon complicationComplication rateMost patientsPostoperative periodTract infectionsSite infection
2013
Postdischarge Complications Predict Reoperation and Mortality after Otolaryngologic Surgery
Chen MM, Roman SA, Sosa JA, Judson BL. Postdischarge Complications Predict Reoperation and Mortality after Otolaryngologic Surgery. Otolaryngology 2013, 149: 865-872. PMID: 24047818, DOI: 10.1177/0194599813505078.Peer-Reviewed Original ResearchConceptsPostdischarge complicationsOtolaryngologic surgerySurgeons National Surgical Quality Improvement ProgramNational Surgical Quality Improvement ProgramSurgical Quality Improvement ProgramProcedure-specific ratesTongue/floorRetrospective cohort studyVenous thromboembolic eventsHigh-risk patientsRisk of reoperationSurgical site infectionOutcomes of interestQuality Improvement ProgramAnesthesiologists classThromboembolic eventsAdult patientsCohort studySite infectionOperative timePostdischarge eventsRisk factorsReoperationAmerican CollegeSurgeryPost‐discharge Complications Predict Reoperation and Mortality after Otolaryngology Surgery
Chen M, Roman S, Sosa J, Judson B. Post‐discharge Complications Predict Reoperation and Mortality after Otolaryngology Surgery. Otolaryngology 2013, 149: p51-p51. DOI: 10.1177/0194599813495815a56.Peer-Reviewed Original ResearchPost-discharge complicationsOtolaryngology surgeryComplication rateMultivariate analysisProcedure-specific ratesTongue/floorRetrospective cohort studyVenous thromboembolic eventsACS-NSQIP databaseHigh-risk patientsRisk of reoperationSurgical site infectionLonger operative timeMultivariate logistic regressionPost-discharge eventsOutcomes of interestT-testChi-square testStudent's t-testAnesthesiologists classUnplanned reoperationHospital stayPostoperative complicationsThromboembolic eventsAdult patientsParotid gland lymphoma: Prognostic analysis of 2140 patients
Feinstein AJ, Ciarleglio MM, Cong X, Otremba MD, Judson BL. Parotid gland lymphoma: Prognostic analysis of 2140 patients. The Laryngoscope 2013, 123: 1199-1203. PMID: 23576299, DOI: 10.1002/lary.23901.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge DistributionAgedAged, 80 and overChildChild, PreschoolDisease-Free SurvivalFemaleHumansIncidenceInfantInfant, NewbornKaplan-Meier EstimateLymphomaMaleMiddle AgedParotid NeoplasmsPrognosisProportional Hazards ModelsRetrospective StudiesSEER ProgramSex DistributionSurvival RateUnited StatesYoung AdultConceptsParotid gland lymphomaFacial nerve sacrificeB-cell lymphomaNerve sacrificeHodgkin's lymphomaMarginal zone B-cell lymphomaEnd Results Program databaseKaplan-Meier survival curvesCox proportional hazards modelNon-Hodgkin lymphoma subtypesLarge B-cell lymphomaUS population-based dataRetrospective cohort studyRole of chemotherapyLog-rank testPopulation-based dataForm of surgeryProportional hazards modelCohort studyPatient agePathologic featuresPrognostic importanceMale genderProgram databaseLymphoma subtypes