Prediction of post-radiotherapy locoregional progression in HPV-associated oropharyngeal squamous cell carcinoma using machine-learning analysis of baseline PET/CT radiomics
Haider SP, Sharaf K, Zeevi T, Baumeister P, Reichel C, Forghani R, Kann BH, Petukhova A, Judson BL, Prasad ML, Liu C, Burtness B, Mahajan A, Payabvash S. Prediction of post-radiotherapy locoregional progression in HPV-associated oropharyngeal squamous cell carcinoma using machine-learning analysis of baseline PET/CT radiomics. Translational Oncology 2020, 14: 100906. PMID: 33075658, PMCID: PMC7568193, DOI: 10.1016/j.tranon.2020.100906.Peer-Reviewed Original ResearchOropharyngeal squamous cell carcinomaLocoregional progressionSquamous cell carcinomaRisk stratificationCell carcinomaPrimary tumorBaseline PET/CT scansPET/CT scansBaseline PET/CTKaplan-Meier analysisPET/CT RadiomicsMetastatic cervical lymphPET/CTObjective imaging biomarkersLog-rank p-valueMedian C-indexCervical lymphCT radiomic featuresLocoregional failurePatient selectionTherapeutic challengeObjective biomarkersC-indexCT scanIndependent cohortPrognostic Significance of Extranodal Extension in HPV‐Mediated Oropharyngeal Carcinoma: A Systematic Review and Meta‐analysis
Benchetrit L, Torabi SJ, Givi B, Haughey B, Judson BL. Prognostic Significance of Extranodal Extension in HPV‐Mediated Oropharyngeal Carcinoma: A Systematic Review and Meta‐analysis. Otolaryngology 2020, 164: 720-732. PMID: 32838649, DOI: 10.1177/0194599820951176.Peer-Reviewed Original ResearchConceptsOropharyngeal squamous cell carcinomaExtranodal extensionHazard ratioSystematic reviewHuman papilloma virus-positive oropharyngeal squamous cell carcinomaPathologic extranodal extensionDisease-specific survivalCohort of patientsRefined risk stratificationSquamous cell carcinomaRadiologic extranodal extensionRandom-effects modelDeintensification trialsCause mortalityDistant recurrenceLocoregional recurrenceOverall survivalOropharyngeal carcinomaPrognostic roleDistant metastasisRisk stratificationPrognostic significanceCell carcinomaPrognostic outcomesObservational studyPotential Added Value of PET/CT Radiomics for Survival Prognostication beyond AJCC 8th Edition Staging in Oropharyngeal Squamous Cell Carcinoma
Haider SP, Zeevi T, Baumeister P, Reichel C, Sharaf K, Forghani R, Kann BH, Judson BL, Prasad ML, Burtness B, Mahajan A, Payabvash S. Potential Added Value of PET/CT Radiomics for Survival Prognostication beyond AJCC 8th Edition Staging in Oropharyngeal Squamous Cell Carcinoma. Cancers 2020, 12: 1778. PMID: 32635216, PMCID: PMC7407414, DOI: 10.3390/cancers12071778.Peer-Reviewed Original ResearchOropharyngeal squamous cell carcinomaProgression-free survivalPositron emission tomographySquamous cell carcinomaOverall survivalC-indexRisk stratificationCell carcinomaSurvival prognosticationHPV-negative oropharyngeal squamous cell carcinomaPre-treatment PET/CTMetastatic cervical lymph nodesBaseline positron emission tomographyBaseline distant metastasesCervical lymph nodesHuman papillomavirus (HPV) statusAmerican Joint CommitteeKaplan-Meier analysisPET/CT RadiomicsHarrell's C-indexAverage C-indexPET/CTRadiomics imaging featuresCurative intentDistant metastasis