2020
Revisiting the Radiation Therapy Oncology Group 1221 Hypothesis: Treatment for Stage III/IV HPV-Negative Oropharyngeal Cancer
Jacobs D, Torabi SJ, Park HS, Rahmati R, Young MR, Mehra S, Judson BL. Revisiting the Radiation Therapy Oncology Group 1221 Hypothesis: Treatment for Stage III/IV HPV-Negative Oropharyngeal Cancer. Otolaryngology 2020, 164: 1240-1248. PMID: 33198564, DOI: 10.1177/0194599820969613.Peer-Reviewed Original ResearchConceptsNational Cancer DatabaseHPV-negative oropharyngeal cancersChemoradiation therapyOverall survivalCancer DatabaseOropharyngeal cancerHPV-negative oropharyngeal squamous cell carcinomaLarge national cancer databaseNeck cancer-specific survivalOropharyngeal squamous cell carcinomaCox proportional hazards regressionKaplan-Meier survival analysisCancer-specific survivalImproved overall survivalMultivariable Cox regressionRetrospective cohort studyAdjuvant chemoradiation therapyUse of surgeryEnd Results ProgramProportional hazards regressionSquamous cell carcinomaSEER cohortAdjuvant therapyCohort studySEER databasePrimary Treatment Selection for Clinically Node-Negative Merkel Cell Carcinoma of the Head and Neck
Jacobs D, Olino K, Park HS, Clune J, Cheraghlou S, Girardi M, Burtness B, Kluger H, Judson BL. Primary Treatment Selection for Clinically Node-Negative Merkel Cell Carcinoma of the Head and Neck. Otolaryngology 2020, 164: 1214-1221. PMID: 33079010, DOI: 10.1177/0194599820967001.Peer-Reviewed Original ResearchConceptsNode-negative Merkel cell carcinomaLymph node evaluationImproved overall survivalPrimary tumor excisionMerkel cell carcinomaCase volumeOverall survivalSurgical managementCell carcinomaTumor excisionTreatment selectionNode evaluationCox proportional hazards regressionGuideline-recommended carePrimary treatment selectionNational Cancer DatabaseNode-negative diseasePercentage of patientsRetrospective cohort analysisInitial surgical managementKaplan-Meier analysisWide local excisionProportional hazards regressionRates of receiptInitial management
2019
Preoperative biopsy in parotid malignancies: Variation in use and impact on surgical margins
Benchetrit L, Torabi SJ, Morse E, Mehra S, Rahmati R, Osborn HA, Judson BL. Preoperative biopsy in parotid malignancies: Variation in use and impact on surgical margins. The Laryngoscope 2019, 130: 1450-1458. PMID: 31411749, DOI: 10.1002/lary.28224.Peer-Reviewed Original ResearchConceptsPreoperative biopsyParotid malignanciesSurgical marginsPositive marginsClinical T1 stageNational Cancer DatabaseClinical T stageClinical N stageHigh-volume centersSubgroup of patientsMultivariable logistic regressionEarly clinical stageChi-square testAdjuvant therapyRetrospective cohortYounger patientsT stageClinical stageSurgical outcomesVolume centersBiopsy useCancer DatabaseN stageBiopsyPatients
2018
Hypopharyngeal Cancer Treatment Delays: Benchmarks and Survival Association
Morse E, Berson E, Fujiwara R, Judson B, Mehra S. Hypopharyngeal Cancer Treatment Delays: Benchmarks and Survival Association. Otolaryngology 2018, 160: 267-276. PMID: 30324861, DOI: 10.1177/0194599818797605.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBenchmarkingCarcinoma, Squamous CellChemoradiotherapyCohort StudiesDisease-Free SurvivalFemaleHumansHypopharyngeal NeoplasmsLogistic ModelsMaleMiddle AgedMultivariate AnalysisPrognosisProportional Hazards ModelsRadiotherapy, ConformalRetrospective StudiesRisk AssessmentSurvival AnalysisTime-to-TreatmentTreatment OutcomeConceptsRadiation treatment durationOverall survivalInduction chemotherapyMedian durationConcurrent chemoradiationHypopharyngeal cancerCox proportional hazards regressionNational Cancer DatabaseProportional hazards regressionMultivariable logisticRetrospective cohortTreatment initiationMedicaid insuranceTreatment delayCancer HospitalHazards regressionNonwhite raceCancer DatabaseTreatment endSurvival associationsTreatment durationPatientsChemoradiationChemotherapyTreatment factors
2017
Thirty‐day morbidity and mortality following otologic/neurotologic surgery: Analysis of the national surgical quality improvement program
Schwam ZG, Michaelides E, Kuo P, Hajek MA, Judson BL, Schutt C. Thirty‐day morbidity and mortality following otologic/neurotologic surgery: Analysis of the national surgical quality improvement program. The Laryngoscope 2017, 128: 1431-1437. PMID: 28940480, DOI: 10.1002/lary.26848.Peer-Reviewed Original ResearchConceptsNational Surgical Quality Improvement ProgramSurgical Quality Improvement ProgramAdverse event ratesQuality Improvement ProgramPostoperative morbidityFunctional statusTumor resectionNeurotologic surgerySurgeons National Surgical Quality Improvement ProgramOpen woundsOverall adverse event rateEvent ratesHigher adverse event ratesThirty-day morbidityPoor functional statusRetrospective cohort studyOverall mortality rateMultivariable logistic regressionImpaired functional statusMastoid proceduresPostoperative mortalityMajor morbidityPostoperative complicationsSignificant comorbiditiesCohort studyTreatment delays in oral cavity squamous cell carcinoma and association with survival
Fujiwara RJ, Judson BL, Yarbrough WG, Husain Z, Mehra S. Treatment delays in oral cavity squamous cell carcinoma and association with survival. Head & Neck 2017, 39: 639-646. PMID: 28236349, DOI: 10.1002/hed.24608.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCarcinoma, Squamous CellCause of DeathChemoradiotherapy, AdjuvantCohort StudiesCombined Modality TherapyDatabases, FactualDisease-Free SurvivalFemaleHead and Neck NeoplasmsHumansKaplan-Meier EstimateMaleMiddle AgedMouth NeoplasmsNeoplasm InvasivenessNeoplasm StagingPredictive Value of TestsPrognosisProportional Hazards ModelsRetrospective StudiesRisk AssessmentSquamous Cell Carcinoma of Head and NeckSurvival AnalysisTime-to-TreatmentUnited StatesConceptsSquamous cell carcinomaOral cavity squamous cell carcinomaNational Cancer Data BaseOverall survivalRT durationTotal treatment packageCox proportional hazards modelDecreased overall survivalProportional hazards modelTreatment packageBinary logistic regressionMedicaid insuranceTreatment delayCell carcinomaAcademic/research institutionsHazards modelLate PTSurgery delayTreatment durationRadiotherapySurgeryLogistic regressionDiagnosisDurationImpact of delay
2016
Treatment delay and facility case volume are associated with survival in early‐stage glottic cancer
Cheraghlou S, Kuo P, Judson BL. Treatment delay and facility case volume are associated with survival in early‐stage glottic cancer. The Laryngoscope 2016, 127: 616-622. PMID: 27653749, DOI: 10.1002/lary.26259.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAntineoplastic Combined Chemotherapy ProtocolsCohort StudiesCombined Modality TherapyDisease-Free SurvivalEarly Detection of CancerFemaleGlottisHospitals, High-VolumeHumansKaplan-Meier EstimateLaryngeal NeoplasmsLaryngectomyMaleMiddle AgedOrgan Sparing TreatmentsProportional Hazards ModelsRadiotherapy, AdjuvantRetrospective StudiesRisk AssessmentSurvival AnalysisTime FactorsWaiting ListsConceptsEarly-stage glottic cancerGlottic cancerUnivariate Kaplan-Meier analysisSystem factorsFacility case volumeNational Cancer DatabaseMultivariate Cox regressionEarly glottic cancerKaplan-Meier analysisImprovement of outcomesTumor factorsAdult patientsWorse survivalImproved survivalNumber of treatmentsRetrospective studyTreatment delayCox regressionCancer DatabaseCase volumeGovernment insurancePatientsCancerTreatment factorsSurvival variables
2014
Hypopharyngeal cancer incidence, treatment, and survival: Temporal trends in the United States
Kuo P, Chen MM, Decker RH, Yarbrough WG, Judson BL. Hypopharyngeal cancer incidence, treatment, and survival: Temporal trends in the United States. The Laryngoscope 2014, 124: 2064-2069. PMID: 25295351, DOI: 10.1002/lary.24651.Peer-Reviewed Original ResearchConceptsAverage annual percent changeHypopharyngeal cancerPatient demographicsTreatment modalitiesDisease severityEnd Results (SEER) databaseRetrospective cohort studyKaplan-Meier analysisAnnual percent changeAdult patientsCohort studyOverall survivalWorse survivalImproved survivalResults databaseT stageTumor characteristicsCox regressionCancer incidenceMultivariate analysisPercent changeLaryngopharyngectomyCancerIncidenceTemporal trends
2013
Postdischarge Complications Predict Reoperation and Mortality after Otolaryngologic Surgery
Chen MM, Roman SA, Sosa JA, Judson BL. Postdischarge Complications Predict Reoperation and Mortality after Otolaryngologic Surgery. Otolaryngology 2013, 149: 865-872. PMID: 24047818, DOI: 10.1177/0194599813505078.Peer-Reviewed Original ResearchConceptsPostdischarge complicationsOtolaryngologic surgerySurgeons National Surgical Quality Improvement ProgramNational Surgical Quality Improvement ProgramSurgical Quality Improvement ProgramProcedure-specific ratesTongue/floorRetrospective cohort studyVenous thromboembolic eventsHigh-risk patientsRisk of reoperationSurgical site infectionOutcomes of interestQuality Improvement ProgramAnesthesiologists classThromboembolic eventsAdult patientsCohort studySite infectionOperative timePostdischarge eventsRisk factorsReoperationAmerican CollegeSurgery
2012
The Prognostic Importance of Midline Involvement in Oral Tongue Cancer
Lloyd S, Yu JB, Wilson LD, Judson BL, Decker RH. The Prognostic Importance of Midline Involvement in Oral Tongue Cancer. American Journal Of Clinical Oncology 2012, 35: 468-473. PMID: 21701377, PMCID: PMC3755371, DOI: 10.1097/coc.0b013e3182195619.Peer-Reviewed Original ResearchConceptsContralateral lymph node metastasisLymph node metastasisOral tongue squamous cell carcinomaTongue squamous cell carcinomaT2-3 diseaseSquamous cell carcinomaNode metastasisClinicopathologic factorsCell carcinomaMidline involvementEnd Results (SEER) dataLymph node statusOral tongue cancerDifferent prognostic classesLateral tumorsT4 tumorsT1 tumorsT3 tumorsT4 lesionsHistologic subtypeT3 lesionsNode statusPrognostic importanceT classificationTongue cancerRole of excision repair cross‐complementation 1 expression as a prognostic marker for response to radiotherapy in early‐stage laryngeal cancer
Johung K, Rewari A, Wu H, Judson B, Contessa JN, Haffty BG, Decker RH. Role of excision repair cross‐complementation 1 expression as a prognostic marker for response to radiotherapy in early‐stage laryngeal cancer. Head & Neck 2012, 35: 852-857. PMID: 22740347, PMCID: PMC5723082, DOI: 10.1002/hed.23041.Peer-Reviewed Original ResearchConceptsERCC1 expressionOverall survivalExcision repair crossLocal controlT classificationLaryngeal cancerEarly-stage laryngeal cancerLaryngeal squamous cell carcinomaClinicopathologic risk factorsHigh ERCC1 expressionPlatinum-based chemotherapySquamous cell carcinomaWorse survivalCell carcinomaPrognostic valueStandard radiotherapyPrognostic markerRisk factorsEffective treatmentImmunohistochemical analysisTissue microarrayStage IRadiotherapy resistanceMultivariate analysisRadiotherapy