2018
Positive surgical margins in parotid malignancies: Institutional variation and survival association
Morse E, Fujiwara RJT, Judson B, Prasad ML, Mehra S. Positive surgical margins in parotid malignancies: Institutional variation and survival association. The Laryngoscope 2018, 129: 129-137. PMID: 30194762, DOI: 10.1002/lary.27221.Peer-Reviewed Original ResearchConceptsPositive surgical marginsPositive margin rateOverall survivalSurgical marginsHigh-volume facilitiesMargin ratePositive marginsParotid malignanciesMucoepidermoid carcinomaCox proportional hazards regressionOverall positive margin rateLow-grade mucoepidermoid carcinomaNational Cancer DatabaseProportional hazards regressionMultivariable logistic regressionPositive margin statusRetrospective database analysisParotid cancerMargin statusHazards regressionCancer DatabaseSurvival associationsDecreased oddsCystic carcinomaPatients
2016
NOTCH1 and SOX10 are Essential for Proliferation and Radiation Resistance of Cancer Stem–Like Cells in Adenoid Cystic Carcinoma
Panaccione A, Chang MT, Carbone BE, Guo Y, Moskaluk CA, Virk RK, Chiriboga L, Prasad ML, Judson B, Mehra S, Yarbrough WG, Ivanov SV. NOTCH1 and SOX10 are Essential for Proliferation and Radiation Resistance of Cancer Stem–Like Cells in Adenoid Cystic Carcinoma. Clinical Cancer Research 2016, 22: 2083-2095. PMID: 27084744, PMCID: PMC4834904, DOI: 10.1158/1078-0432.ccr-15-2208.Peer-Reviewed Original ResearchMeSH KeywordsAC133 AntigenAmyloid Precursor Protein SecretasesAnimalsBiomarkers, TumorCarcinoma, Adenoid CysticCell Line, TumorCell Transformation, NeoplasticCyclin-Dependent Kinase Inhibitor p27Disease Models, AnimalFatty Acid-Binding Protein 7Gene Expression ProfilingHeterograftsHumansLigandsMiceMice, NudeNeoplasm GradingNeoplastic Stem CellsProtein BindingRadiationRadiation ToleranceReceptor, Notch1SOXE Transcription FactorsS-Phase Kinase-Associated ProteinsTumor Cells, CulturedTumor Suppressor ProteinsConceptsCancer stem cellsRibosome biogenesisCancer stem-like cellsStem-like cellsLack of assaysCSC maintenanceMolecular markersNeural differentiationCell deathUncharacterized populationACC therapyΓ-secretase inhibitorCSC viabilityCD133-positive cancer stem cellsStem cellsCell sortingSOX10Essential roleSkp2Notch1P27Kip1Stem propertiesCell culturesImmunomagnetic cell sortingCells
2013
Histologic grade as prognostic indicator for mucoepidermoid carcinoma: A population‐level analysis of 2400 patients
Chen MM, Roman SA, Sosa JA, Judson BL. Histologic grade as prognostic indicator for mucoepidermoid carcinoma: A population‐level analysis of 2400 patients. Head & Neck 2013, 36: 158-163. PMID: 23765800, DOI: 10.1002/hed.23256.Peer-Reviewed Original ResearchConceptsHigh-grade mucoepidermoid carcinomaDisease-specific survivalMucoepidermoid carcinomaNodal metastasisFive-year DSS ratesIntermediate-grade mucoepidermoid carcinomaEnd Results (SEER) databaseNegative prognostic factorParotid mucoepidermoid carcinomaHigh gradeFirst population-level studyExtraparenchymal extensionDSS ratesPatient ageUncommon malignancyPrognostic factorsDistant metastasisResults databaseTumor sizeHistologic gradePrognostic indicatorLevel IParotid glandMetastasisLarger study
2012
The Prognostic Importance of Midline Involvement in Oral Tongue Cancer
Lloyd S, Yu JB, Wilson LD, Judson BL, Decker RH. The Prognostic Importance of Midline Involvement in Oral Tongue Cancer. American Journal Of Clinical Oncology 2012, 35: 468-473. PMID: 21701377, PMCID: PMC3755371, DOI: 10.1097/coc.0b013e3182195619.Peer-Reviewed Original ResearchConceptsContralateral lymph node metastasisLymph node metastasisOral tongue squamous cell carcinomaTongue squamous cell carcinomaT2-3 diseaseSquamous cell carcinomaNode metastasisClinicopathologic factorsCell carcinomaMidline involvementEnd Results (SEER) dataLymph node statusOral tongue cancerDifferent prognostic classesLateral tumorsT4 tumorsT1 tumorsT3 tumorsT4 lesionsHistologic subtypeT3 lesionsNode statusPrognostic importanceT classificationTongue cancer