1999
Dermatan sulfate activates nuclear factor-κb and induces endothelial and circulating intercellular adhesion molecule-1
Penc S, Pomahac B, Eriksson E, Detmar M, Gallo R. Dermatan sulfate activates nuclear factor-κb and induces endothelial and circulating intercellular adhesion molecule-1. Journal Of Clinical Investigation 1999, 103: 1329-1335. PMID: 10225976, PMCID: PMC408352, DOI: 10.1172/jci4742.Peer-Reviewed Original ResearchConceptsICAM-1Effect of DSDermatan sulfateCell surface ICAM-1Intercellular adhesion molecule-1Endothelial cellsCultured human dermal microvascular endothelial cellsIntercellular adhesion molecule-1 mRNAIL-1 releaseAdhesion molecule-1Surface ICAM-1Human dermal microvascular endothelial cellsDermal microvascular endothelial cellsMicrovascular endothelial cellsNF-kappaB activationNuclear factor-kappaBTNF-alphaInflammatory phaseMolecule-1Chondroitin sulfate BFactor-kappaBSoluble ICAMChondroitin sulfate ANF-kappaBPhysiologic concentrations
1998
Dermatan Sulfate Released after Injury Is a Potent Promoter of Fibroblast Growth Factor-2 Function*
Penc S, Pomahac B, Winkler T, Dorschner R, Eriksson E, Herndon M, Gallo R. Dermatan Sulfate Released after Injury Is a Potent Promoter of Fibroblast Growth Factor-2 Function*. Journal Of Biological Chemistry 1998, 273: 28116-28121. PMID: 9774430, DOI: 10.1074/jbc.273.43.28116.Peer-Reviewed Original ResearchConceptsWound fluidDermatan sulfateFactor 2 activityFibroblast growth factor-2Growth factor 2Factor 2 functionHuman wound fluidPotent mediatorSulfated glycosaminoglycan concentrationsSyndecan-1Fibroblast growth factor‐2 activityWound repairWound healingCell proliferationFGF-2Glycosaminoglycan concentrationSoluble proteoglycanFactor 2Immunoblot analysisVivo sourceHeparan sulfatePotent promoterFirst evidenceSyndecan-4Proteoglycans