2023
Cellular activation pathways and interaction networks in vascularized composite allotransplantation
Knoedler L, Knoedler S, Panayi A, Lee C, Sadigh S, Huelsboemer L, Stoegner V, Schroeter A, Kern B, Mookerjee V, Lian C, Tullius S, Murphy G, Pomahac B, Kauke-Navarro M. Cellular activation pathways and interaction networks in vascularized composite allotransplantation. Frontiers In Immunology 2023, 14: 1179355. PMID: 37266446, PMCID: PMC10230044, DOI: 10.3389/fimmu.2023.1179355.Peer-Reviewed Original ResearchConceptsVascularized Composite AllotransplantationComposite allotransplantationRecipient-derived lymphocytesTreatment of patientsCellular activation pathwaysMultidrug immunosuppressionVCA graftsVCA patientsVCA rejectionGraft rejectionDevastating injuriesClinical managementNovel therapiesReconstructive surgeryLimb lossRejection responseFacial disfigurementAllotransplantationPatientsGraftActivation pathwayTissue cellsDifferent cell typesTissue typesCell types
2020
All hands on deck: Hand replantation versus transplantation
Heineman J, Bueno E, Kiwanuka H, Carty M, Sampson C, Pribaz J, Pomahac B, Talbot S. All hands on deck: Hand replantation versus transplantation. SAGE Open Medicine 2020, 8: 2050312120926351. PMID: 32537157, PMCID: PMC7268554, DOI: 10.1177/2050312120926351.Peer-Reviewed Original ResearchHand replantationAdverse events/side effectsSystematic reviewPatient satisfaction/qualityPost-operative considerationsDeterminants of outcomePre-operative considerationsMeta-Analyses (PRISMA) guidelinesSatisfaction/qualityPreferred Reporting ItemsBest possible outcomeUpper limb lossAcute amputationsSurgical repairHand transplantationSurgical techniqueOperative techniquePatient commitmentComplete amputationDaily livingForearm levelLimb lossPatient expectationsSide effectsBetter outcomes
2016
A Mobile Extracorporeal Extremity Salvage System for Replantation and Transplantation
Kueckelhaus M, Fischer S, Sisk G, Kiwanuka H, Bueno E, Dermietzel A, Alhefzi M, Aycart M, Diehm Y, Pomahac B. A Mobile Extracorporeal Extremity Salvage System for Replantation and Transplantation. Annals Of Plastic Surgery 2016, 76: 355-360. PMID: 26808757, DOI: 10.1097/sap.0000000000000681.Peer-Reviewed Original ResearchConceptsMuscle damageLimb lossPerfusion deviceDeceased organ donorsIschemic muscle damageBilateral hind limbsPreferred treatmentBilateral limbsMuscle biopsyOrgan donorsTraumatic amputationHealthy limbPerfusion solutionReplantationArterial systemTransplantationHypoxic cellsPerfusate compositionHind limbPorcine limbsLimbSignificant differencesYorkshire pigsSalvage systemSimilar changes
2014
Facial and Hand Allotransplantation
Pomahac B, Gobble R, Schneeberger S. Facial and Hand Allotransplantation. Cold Spring Harbor Perspectives In Medicine 2014, 4: a015651. PMID: 24478387, PMCID: PMC3935393, DOI: 10.1101/cshperspect.a015651.Peer-Reviewed Original ResearchConceptsVascularized Composite AllotransplantationFacial transplantationLong-term immunosuppressionMinimization of immunosuppressionGood functional outcomeTreatment of patientsMultidisciplinary team approachNovel therapeutic optionsSevere facial disfigurementAllograft survivalHand allotransplantationSkin rejectionTherapeutic optionsFunctional outcomeLimb lossComposite allotransplantationSide effectsTeam approachTransplantationSurgical planningFacial disfigurementImmunosuppressionAllotransplantationComplex proceduresPatients