Local immunosuppression in vascularized composite allotransplantation (VCA): A systematic review
Safi AF, Kauke M, Nelms L, Palmer WJ, Tchiloemba B, Kollar B, Haug V, Pomahač B. Local immunosuppression in vascularized composite allotransplantation (VCA): A systematic review. Journal Of Plastic Reconstructive & Aesthetic Surgery 2020, 74: 327-335. PMID: 33229219, DOI: 10.1016/j.bjps.2020.10.003.Peer-Reviewed Original ResearchConceptsLocal immunosuppressionSystematic reviewAllograft survivalComposite allotransplantationAllograft survival dataCell-based therapy strategiesImproved allograft survivalMain immunosuppressive agentMeta-Analyses (PRISMA) guidelinesPreclinical animal studiesPreferred Reporting ItemsMalignant side effectsImmunosuppressive agentsPreclinical dataSignificant prolongationRat modelHuman trialsExclusion criteriaImmunosuppressionSide effectsAnimal studiesReporting ItemsPubMed databaseSystemic toxicityTherapy strategiesAll hands on deck: Hand replantation versus transplantation
Heineman J, Bueno E, Kiwanuka H, Carty M, Sampson C, Pribaz J, Pomahac B, Talbot S. All hands on deck: Hand replantation versus transplantation. SAGE Open Medicine 2020, 8: 2050312120926351. PMID: 32537157, PMCID: PMC7268554, DOI: 10.1177/2050312120926351.Peer-Reviewed Original ResearchHand replantationAdverse events/side effectsSystematic reviewPatient satisfaction/qualityPost-operative considerationsDeterminants of outcomePre-operative considerationsMeta-Analyses (PRISMA) guidelinesSatisfaction/qualityPreferred Reporting ItemsBest possible outcomeUpper limb lossAcute amputationsSurgical repairHand transplantationSurgical techniqueOperative techniquePatient commitmentComplete amputationDaily livingForearm levelLimb lossPatient expectationsSide effectsBetter outcomes