2021
CD1a selectively captures endogenous cellular lipids that broadly block T cell response
Cotton R, Wegrecki M, Cheng T, Chen Y, Veerapen N, Le Nours J, Orgill D, Pomahac B, Talbot S, Willis R, Altman J, de Jong A, Van Rhijn I, Clark R, Besra G, Ogg G, Rossjohn J, Moody D. CD1a selectively captures endogenous cellular lipids that broadly block T cell response. Journal Of Experimental Medicine 2021, 218: e20202699. PMID: 33961028, PMCID: PMC8111460, DOI: 10.1084/jem.20202699.Peer-Reviewed Original ResearchConceptsNatural endogenous inhibitorsEndogenous lipidsCD1a proteinCellular lipidsT cell activationMembrane phospholipidsLonger lipidsSurface residuesEndogenous inhibitorLipidomics methodDetailed chemical structureCell activationLipidsCellsNatural blockerSphingolipidsDisplay platformProteinCrystal structureResiduesCell responsesBindingTetramerC42SphingomyelinImmunoregulatory and lipid presentation pathways are upregulated in human face transplant rejection
Win T, Crisler W, Dyring-Andersen B, Lopdrup R, Teague J, Zhan Q, Barrera V, Sui S, Tasigiorgos S, Murakami N, Chandraker A, Tullius S, Pomahac B, Riella L, Clark R. Immunoregulatory and lipid presentation pathways are upregulated in human face transplant rejection. Journal Of Clinical Investigation 2021, 131 PMID: 33667197, PMCID: PMC8262560, DOI: 10.1172/jci135166.Peer-Reviewed Original ResearchConceptsVCA rejectionTransplant rejectionT cellsTissue injuryGene expression profilingAntigen-presenting cell activationT-cell receptor sequencingSolid organ transplantsCell receptor sequencingT cell activation pathwaysAntigen-specific activationProliferative T cellsCell activation pathwaysNovo Nordisk FoundationAmerican SocietyExpression profilingFace transplant patientsTransplant patientsImmunologic pathwaysImmunoregulatory networkSkin biopsiesImmunomodulatory pathwaysLimb transplantsLundbeck FoundationTransplant ResearchHuman skin is colonized by T cells that recognize CD1a independently of lipid
Cotton R, Cheng T, Wegrecki M, Le Nours J, Orgill D, Pomahac B, Talbot S, Willis R, Altman J, de Jong A, Ogg G, Van Rhijn I, Rossjohn J, Clark R, Moody D. Human skin is colonized by T cells that recognize CD1a independently of lipid. Journal Of Clinical Investigation 2021, 131: e140706. PMID: 33393500, PMCID: PMC7773353, DOI: 10.1172/jci140706.Peer-Reviewed Original ResearchMeSH KeywordsAntigens, CD1HEK293 CellsHumansK562 CellsMembrane LipidsReceptors, Antigen, T-CellSkinT-LymphocytesConceptsT cellsSelf-lipid antigensSkin T cellsT cell autoreactivityT cell poolT cell repertoireMajor antigenic targetAntigenic targetsCell repertoireClinical diseaseCD1aSkin diseasesCD1 proteinsAntigenTCR recognitionCell poolEffector moleculesCD1a proteinLipid ligandsSmall antigensDiseaseHuman skinCellsAutoreactivityLipids
2016
Immunological Characteristics of a Patient With Belatacept‐Resistant Acute Rejection After Face Transplantation
Krezdorn N, Murakami N, Pomahac B, Riella L. Immunological Characteristics of a Patient With Belatacept‐Resistant Acute Rejection After Face Transplantation. American Journal Of Transplantation 2016, 16: 3305-3307. PMID: 27457067, PMCID: PMC5087655, DOI: 10.1111/ajt.13977.Peer-Reviewed Original Research
2014
Biomarker evaluation of face transplant rejection: association of donor T cells with target cell injury
Lian C, Bueno E, Granter S, Laga A, Saavedra A, Lin W, Susa J, Zhan Q, Chandraker A, Tullius S, Pomahac B, Murphy G. Biomarker evaluation of face transplant rejection: association of donor T cells with target cell injury. Modern Pathology 2014, 27: 788-799. PMID: 24434898, DOI: 10.1038/modpathol.2013.249.Peer-Reviewed Original ResearchConceptsTarget cell injurySkin allograft rejectionDonor T cellsRecipient T cellsT cellsCell injuryAllograft rejectionMemory T cell subsetsAssessment of rejectionFacial transplantT cell subsetsPotential translational significanceImmune cell interactionsRejection episodesClinicopathological assessmentFollicular infundibulumHistologic evidenceSerial biopsiesTransplant rejectionEpidermal targetsDonor originImmune cellsSequential biopsiesDermal microvesselsTranslational significance