2023
Vascularized Composite Allograft Versus Prosthetic for Reconstruction After Facial and Hand Trauma
Noel O, Dumbrava M, Daoud D, Kammien A, Kauke-Navarro M, Pomahac B, Colen D. Vascularized Composite Allograft Versus Prosthetic for Reconstruction After Facial and Hand Trauma. Annals Of Plastic Surgery 2023, 92: 100-105. PMID: 37962243, DOI: 10.1097/sap.0000000000003731.Peer-Reviewed Original ResearchMeSH KeywordsComposite Tissue AllograftsFacial InjuriesHumansPlastic Surgery ProceduresUpper ExtremityVascularized Composite AllotransplantationConceptsHand traumaHand/upper extremityLong-term outcomesUpper extremity traumaDifferent reconstructive optionsUse of prosthesesExtremity traumaBenefit profileUpper extremityReconstructive optionsComposite allotransplantationFace traumaHand reconstructionTraumaClinical realityPrimary optionProsthesisPatientsVCACellular activation pathways and interaction networks in vascularized composite allotransplantation
Knoedler L, Knoedler S, Panayi A, Lee C, Sadigh S, Huelsboemer L, Stoegner V, Schroeter A, Kern B, Mookerjee V, Lian C, Tullius S, Murphy G, Pomahac B, Kauke-Navarro M. Cellular activation pathways and interaction networks in vascularized composite allotransplantation. Frontiers In Immunology 2023, 14: 1179355. PMID: 37266446, PMCID: PMC10230044, DOI: 10.3389/fimmu.2023.1179355.Peer-Reviewed Original ResearchMeSH KeywordsGraft RejectionHumansImmune ToleranceImmunosuppression TherapyTransplantation, HomologousVascularized Composite AllotransplantationConceptsVascularized Composite AllotransplantationComposite allotransplantationRecipient-derived lymphocytesTreatment of patientsCellular activation pathwaysMultidrug immunosuppressionVCA graftsVCA patientsVCA rejectionGraft rejectionDevastating injuriesClinical managementNovel therapiesReconstructive surgeryLimb lossRejection responseFacial disfigurementAllotransplantationPatientsGraftActivation pathwayTissue cellsDifferent cell typesTissue typesCell typesCorrelation between facial vascularized composite allotransplantation rejection and laboratory markers: Insights from a retrospective study of eight patients
Kauke-Navarro M, Knoedler S, Panayi A, Knoedler L, Haller B, Parikh N, Huelsboemer L, Stoegner V, Kiefer J, Eisenhardt S, Azzi J, Pomahac B. Correlation between facial vascularized composite allotransplantation rejection and laboratory markers: Insights from a retrospective study of eight patients. Journal Of Plastic Reconstructive & Aesthetic Surgery 2023, 83: 155-164. PMID: 37276734, DOI: 10.1016/j.bjps.2023.04.050.Peer-Reviewed Original ResearchBiomarkersGraft RejectionHumansRetrospective StudiesTransplantation, HomologousVascularized Composite AllotransplantationInsights from immunoproteomic profiling of a rejected full-face transplant
Lee C, Wang D, Kauke-Navarro M, Russell-Goldman E, Xu S, Mucciarone K, Sohrabi S, Lian C, Pomahac B, Murphy G. Insights from immunoproteomic profiling of a rejected full-face transplant. American Journal Of Transplantation 2023, 23: 1058-1061. PMID: 37037378, DOI: 10.1016/j.ajt.2023.04.008.Peer-Reviewed Original ResearchMeSH KeywordsComposite Tissue AllograftsFacial TransplantationGraft RejectionGraft SurvivalProteomicsVascularized Composite AllotransplantationConceptsVascularized Composite AllograftsT cellsChronic rejectionCD8-positive T cellsEffector T cellsFull face transplantArteriosclerotic alterationsIntragraft arteriesVCA rejectionGraft arteryAccelerated arteriosclerosisRecipient originPunch biopsyAtherogenic responseComposite allograftsImmunoproteomic profilingDioxygenase 1Target endotheliumArteryEndotheliumProteomic profilingPathway componentsCellsRejectionAllografts
2022
Regulatory T Cells: Liquid and Living Precision Medicine for the Future of VCA
Kauke-Navarro M, Knoedler S, Panayi AC, Knoedler L, Noel OF, Pomahac B. Regulatory T Cells: Liquid and Living Precision Medicine for the Future of VCA. Transplantation 2022, 107: 86-97. PMID: 36210500, DOI: 10.1097/tp.0000000000004342.Peer-Reviewed Original ResearchMeSH KeywordsGraft RejectionImmune TolerancePrecision MedicineT-Lymphocytes, RegulatoryVascularized Composite AllotransplantationConceptsSolid organ transplantationOrgan transplantationSide effectsField of VCAMedication side effectsBeneficial clinical effectsChimeric antigen receptorSevere side effectsRisk of infectionT cell receptorMaintenance immunosupressionMetabolic complicationsClinical effectsTransplant rejectionLifelong immunosuppressionImmune cellsTregsComposite allotransplantationSpecific antigenTherapeutic efficacyAntigen receptorStable levelPrecision medicineImmune system mechanismsImmunotoleranceCytomegalovirus-related Complications and Management in Facial Vascularized Composite Allotransplantation: An International Multicenter Retrospective Cohort Study
Kauke-Navarro M, Panayi AC, Formica R, Marty F, Parikh N, Foroutanjazi S, Safi AF, Mardini S, Razonable RR, Morelon E, Gelb B, Rodriguez E, Lassus P, Pomahac B. Cytomegalovirus-related Complications and Management in Facial Vascularized Composite Allotransplantation: An International Multicenter Retrospective Cohort Study. Transplantation 2022, 106: 2031-2043. PMID: 35389381, DOI: 10.1097/tp.0000000000004132.Peer-Reviewed Original ResearchMeSH KeywordsAntiviral AgentsCytomegalovirusCytomegalovirus InfectionsHumansRetrospective StudiesValganciclovirVascularized Composite AllotransplantationViremiaConceptsRetrospective cohort studyAntiviral prophylaxisCohort studyComposite allotransplantationInternational multicenter retrospective cohort studyMulticenter retrospective cohort studyCMV-related complicationsFirst year posttransplantHigh-risk transplantsMore rejection episodesHigh-risk groupFacial Vascularized Composite AllotransplantationAllograft-related complicationsVascularized Composite AllotransplantationPaucity of dataAllograft lossCMV diseaseCMV viremiaCytomegalovirus serostatusR serostatusRejection episodesCMV infectionPrompt treatmentActive surveillancePatients
2021
Patient-reported outcomes measures used in facial vascularized composite allotransplantation: A systematic literature review
Fullerton Z, Tsangaris E, DeVries C, Klassen A, Aycart M, Sidey-Gibbons C, Pusic A, Pomahac B. Patient-reported outcomes measures used in facial vascularized composite allotransplantation: A systematic literature review. Journal Of Plastic Reconstructive & Aesthetic Surgery 2021, 75: 33-44. PMID: 34753682, DOI: 10.1016/j.bjps.2021.09.002.Peer-Reviewed Original ResearchMeSH KeywordsFaceHumansPatient Reported Outcome MeasuresQuality of LifeVascularized Composite Allotransplantation
2020
Local immunosuppression in vascularized composite allotransplantation (VCA): A systematic review
Safi AF, Kauke M, Nelms L, Palmer WJ, Tchiloemba B, Kollar B, Haug V, Pomahač B. Local immunosuppression in vascularized composite allotransplantation (VCA): A systematic review. Journal Of Plastic Reconstructive & Aesthetic Surgery 2020, 74: 327-335. PMID: 33229219, DOI: 10.1016/j.bjps.2020.10.003.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsGraft RejectionHumansImmunosuppression TherapyImmunosuppressive AgentsRatsSwineTacrolimusTreatment OutcomeVascularized Composite AllotransplantationConceptsLocal immunosuppressionSystematic reviewAllograft survivalComposite allotransplantationAllograft survival dataCell-based therapy strategiesImproved allograft survivalMain immunosuppressive agentMeta-Analyses (PRISMA) guidelinesPreclinical animal studiesPreferred Reporting ItemsMalignant side effectsImmunosuppressive agentsPreclinical dataSignificant prolongationRat modelHuman trialsExclusion criteriaImmunosuppressionSide effectsAnimal studiesReporting ItemsPubMed databaseSystemic toxicityTherapy strategies
2018
Living Donation of Vascularized Composite Allografts
Pomahac B, Alhefzi M, Bueno E, McDiarmid S, Levin L. Living Donation of Vascularized Composite Allografts. Plastic & Reconstructive Surgery 2018, 142: 405e-411e. PMID: 29927830, DOI: 10.1097/prs.0000000000004659.Peer-Reviewed Original ResearchMeSH KeywordsComposite Tissue AllograftsHumansLiving DonorsPractice Guidelines as TopicTissue and Organ ProcurementVascularized Composite AllotransplantationConceptsComposite allotransplantationComposite allograftsOrgan procurementSolid organ transplantationVascularized Composite AllograftsKidney transplant communityCurrent guidelinesOrgan transplantationTransplant communityTransplantation SocietyClinical scenariosReconstructive strategiesAesthetic outcomeTransplantation NetworkReconstructive ladderReconstructive surgeonTransplant medicineOrgan donationAllotransplantationMedicaid ServicesEthics CommitteeAllograftsDonationSpecific recommendationsExtensive typeExtracorporeal Perfusion in Vascularized Composite Allotransplantation
Kueckelhaus M, Puscz F, Dermietzel A, Dadras M, Fischer S, Krezdorn N, Pomahac B, Hirsch T. Extracorporeal Perfusion in Vascularized Composite Allotransplantation. Annals Of Plastic Surgery 2018, 80: 669-678. PMID: 29746324, DOI: 10.1097/sap.0000000000001477.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsExtracorporeal CirculationForecastingHumansPlastic Surgery ProceduresVascularized Composite AllotransplantationConceptsVascularized Composite AllotransplantationSolid organ transplantationIschemia timeMachine perfusionOrgan transplantationReconstructive surgeryComposite allotransplantationClinical solid organ transplantationMachine perfusion systemImmunosuppressive treatmentGraft immunogenicityBroad clinical applicationLifelong monitoringTherapeutic measuresPerfusion strategyClinical successSevere injuriesPerfusion solutionPreclinical trialsClinical settingPlastic surgeryPerfusionImmunogenicityPerfusion systemClinical application
2017
New Avenues of Vascularized Composite Allotransplantation and their Potential Risks and Benefits
Tasigiorgos S, Krezdorn N, Bueno E, Pomahac B. New Avenues of Vascularized Composite Allotransplantation and their Potential Risks and Benefits. Annals Of Surgery 2017, 266: e25. PMID: 28525412, DOI: 10.1097/sla.0000000000002294.Peer-Reviewed Original ResearchGlobal HealthGraft RejectionHumansIncidenceRisk AssessmentVascularized Composite AllotransplantationChronic Allograft Deterioration: A Clinical Reality in Vascularized Composite Allotransplantation
Krezdorn N, Pomahac B. Chronic Allograft Deterioration: A Clinical Reality in Vascularized Composite Allotransplantation. American Journal Of Transplantation 2017, 17: 1703-1704. PMID: 28371193, DOI: 10.1111/ajt.14291.Peer-Reviewed Original ResearchMeSH KeywordsAllograftsFacial TransplantationTransplantation, HomologousVascularized Composite Allotransplantation
2016
A Mobile Extracorporeal Extremity Salvage System for Replantation and Transplantation
Kueckelhaus M, Fischer S, Sisk G, Kiwanuka H, Bueno E, Dermietzel A, Alhefzi M, Aycart M, Diehm Y, Pomahac B. A Mobile Extracorporeal Extremity Salvage System for Replantation and Transplantation. Annals Of Plastic Surgery 2016, 76: 355-360. PMID: 26808757, DOI: 10.1097/sap.0000000000000681.Peer-Reviewed Original ResearchMeSH KeywordsAmputation, TraumaticAnimalsFeasibility StudiesFemaleLimb SalvagePostoperative ComplicationsRandom AllocationReperfusion InjuryReplantationSwineTissue PreservationTreatment OutcomeVascularized Composite AllotransplantationConceptsMuscle damageLimb lossPerfusion deviceDeceased organ donorsIschemic muscle damageBilateral hind limbsPreferred treatmentBilateral limbsMuscle biopsyOrgan donorsTraumatic amputationHealthy limbPerfusion solutionReplantationArterial systemTransplantationHypoxic cellsPerfusate compositionHind limbPorcine limbsLimbSignificant differencesYorkshire pigsSalvage systemSimilar changes
2015
Facial transplantation
Wo L, Bueno E, Pomahac B. Facial transplantation. Current Opinion In Organ Transplantation 2015, Publish Ahead of Print: &na;. PMID: 26536422, DOI: 10.1097/mot.0000000000000253.Peer-Reviewed Original ResearchMeSH KeywordsAllograftsFacial InjuriesFacial TransplantationHumansRisk FactorsUpper ExtremityVascularized Composite AllotransplantationConceptsPositive HIV statusHIV statusFace transplantComposite allotransplantationUpper extremity transplantsDonor-specific antigensHistory of malignancyLatent viral infectionFacial transplantationChronic rejectionSimultaneous transplantationAbsolute contraindicationCase reportCurrent guidelinesFacial injuriesViral infectionTransplantTransplantationMedical teamAllotransplantationFirst face transplantFace transplantationFacial allotransplantationPatientsPsychological healthVascularized composite allotransplantation: current standards and novel approaches to prevent acute rejection and chronic allograft deterioration
Kueckelhaus M, Fischer S, Seyda M, Bueno E, Aycart M, Alhefzi M, ElKhal A, Pomahac B, Tullius S. Vascularized composite allotransplantation: current standards and novel approaches to prevent acute rejection and chronic allograft deterioration. Transplant International 2015, 29: 655-662. PMID: 26265179, PMCID: PMC4785085, DOI: 10.1111/tri.12652.Peer-Reviewed Original ResearchMeSH KeywordsAllograftsAnimalsAntibodiesBiomarkersGraft RejectionHLA AntigensHumansImmune ToleranceImmunosuppression TherapyImmunosuppressive AgentsTransplantation, HomologousVascularized Composite AllotransplantationConceptsAcute rejectionImproved long-term graft outcomesLong-term graft outcomeChronic allograft deteriorationCytomegalovirus infection statusGraft preservation techniquesUpper extremity transplantationUpper extremity transplantsAntibody-mediated rejectionGood midterm resultsSpecific treatment strategiesAllograft deteriorationChronic rejectionClinical VCAVCA graftsGraft outcomeImmunosuppressive strategiesLocal immunosuppressionMidterm resultsExtremity transplantationCell-based therapiesHLA matchingTolerance inductionTreatment strategiesUS CentersInitial Experience of Dual Maintenance Immunosuppression With Steroid Withdrawal in Vascular Composite Tissue Allotransplantation
Diaz-Siso J, Fischer S, Sisk G, Bueno E, Kueckelhaus M, Talbot S, Carty M, Treister N, Marty F, Milford E, Pomahac B, Tullius S. Initial Experience of Dual Maintenance Immunosuppression With Steroid Withdrawal in Vascular Composite Tissue Allotransplantation. American Journal Of Transplantation 2015, 15: 1421-1431. PMID: 25777324, DOI: 10.1111/ajt.13103.Peer-Reviewed Original ResearchConceptsAcute rejectionVCA recipientsMaintenance immunosuppressionSteroid-resistant acute rejectionLate acute rejectionSolid organ transplantationComposite tissue allotransplantationMaintenance steroidsTopical immunosuppressionCurrent immunosuppressionSteroid withdrawalBolus treatmentOrgan transplantationLow doseImmunosuppressionTissue allotransplantationInitial experienceFurther experienceSteroidsRecipientsTacrolimusPatientsTreatmentMonthsLow levels
2014
Acute rejection in vascularized composite allotransplantation
Fischer S, Lian C, Kueckelhaus M, Strom T, Edelman E, Clark R, Murphy G, Chandraker A, Riella L, Tullius S, Pomahac B. Acute rejection in vascularized composite allotransplantation. Current Opinion In Organ Transplantation 2014, 19: 531-544. PMID: 25333831, DOI: 10.1097/mot.0000000000000140.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAnimalsGraft RejectionHumansImmune ToleranceSkinSkin TransplantationVascularized Composite AllotransplantationConceptsAcute rejection episodesAcute rejectionRejection episodesComposite allotransplantationDepth histological analysisHigh-dose steroidsLong-term safetyField of transplantationBetter diagnostic toolsFace transplant recipientsMaintenance immunosuppressionSteroid withdrawalTransplant recipientsCommon complicationImmunologic eventsAppropriate therapyPatient numbersTimely institutionRestorative surgeryDose reductionEarly diagnosisMost episodesNovel biomarkersHigh immunogenicityPatient careAttitudes Regarding Lower Extremity Allotransplantation among Lower Extremity Amputees
Carty M, Duclos A, Talbot S, Tullius S, Pribaz J, Pomahac B. Attitudes Regarding Lower Extremity Allotransplantation among Lower Extremity Amputees. Plastic & Reconstructive Surgery 2014, 134: 1334-1342. PMID: 25255108, DOI: 10.1097/prs.0000000000000658.Peer-Reviewed Original ResearchAdultAgedAged, 80 and overAmputeesFemaleHealth Care SurveysHumansLower ExtremityMaleMiddle AgedPatient Acceptance of Health CareUnited StatesVascularized Composite AllotransplantationCommon Postburn Deformities and Their Management
Cartotto R, Cicuto B, Kiwanuka H, Bueno E, Pomahac B. Common Postburn Deformities and Their Management. Surgical Clinics Of North America 2014, 94: 817-837. PMID: 25085090, DOI: 10.1016/j.suc.2014.05.006.Peer-Reviewed Original ResearchAxillaBreastBurnsCicatrixContractureCraniocerebral TraumaDonor SelectionEar Deformities, AcquiredElbow InjuriesFacial TransplantationForecastingHand Deformities, AcquiredHumansJoint Deformities, AcquiredLaser TherapyLower ExtremityNeck InjuriesNose Deformities, AcquiredOssification, HeterotopicPerineumSalvage TherapySoft Tissue InjuriesTissue DonorsTransplant Donor SiteVascularized Composite AllotransplantationThe Advent of the Restorative Plastic Surgeon
Carty M, Pribaz J, Talbot S, Caterson E, Pomahac B. The Advent of the Restorative Plastic Surgeon. Plastic & Reconstructive Surgery 2014, 133: 182-186. PMID: 24374677, DOI: 10.1097/01.prs.0000436806.35294.e0.Peer-Reviewed Original ResearchMeSH KeywordsClinical CompetenceHumansInternship and ResidencyPlastic Surgery ProceduresSurgery, PlasticVascularized Composite Allotransplantation