2020
Circulating Donor-derived Cell-free DNA as a Biomarker in Vascularized Composite Allotransplantation?
Haug V, Kuang Y, Tasigiorgos S, Kollar B, Mogili A, Jänne P, Talbot S, Paweletz C, Pomahac B. Circulating Donor-derived Cell-free DNA as a Biomarker in Vascularized Composite Allotransplantation? Transplantation 2020, 104: e79-e80. PMID: 31596743, DOI: 10.1097/tp.0000000000003000.Peer-Reviewed Original Research
2016
Codominant Role of Interferon‐γ– and Interleukin‐17–Producing T Cells During Rejection in Full Facial Transplant Recipients
Borges T, O'Malley J, Wo L, Murakami N, Smith B, Azzi J, Tripathi S, Lane J, Bueno E, Clark R, Tullius S, Chandraker A, Lian C, Murphy G, Strom T, Pomahac B, Najafian N, Riella L. Codominant Role of Interferon‐γ– and Interleukin‐17–Producing T Cells During Rejection in Full Facial Transplant Recipients. American Journal Of Transplantation 2016, 16: 2158-2171. PMID: 26749226, PMCID: PMC4979599, DOI: 10.1111/ajt.13705.Peer-Reviewed Original ResearchConceptsDe novo donor-specific antibody developmentDe novo donor-specific antibodiesInterleukin-17-producing T cellsT helper 2 cell phenotypeFacial transplantationDonor-specific antibody developmentNovo donor-specific antibodiesChemotactic protein-1 levelsPeripheral blood mononuclear cellsAcute cellular rejectionAnti-HLA antibodiesDonor-specific antibodiesFollicular helper cellsImmune cell subsetsProtein-1 levelsBlood mononuclear cellsMedium-term outcomesSkin biopsy specimensFull facial transplantationCellular rejection processLife-changing procedureCellular rejectionCodominant roleDonor alloreactivityTransplant recipients
2015
Transformation of Face Transplants: Volumetric and Morphologic Graft Changes Resemble Aging After Facial Allotransplantation
Kueckelhaus M, Turk M, Kumamaru K, Wo L, Bueno E, Lian C, Alhefzi M, Aycart M, Fischer S, De Girolami U, Murphy G, Rybicki F, Pomahac B. Transformation of Face Transplants: Volumetric and Morphologic Graft Changes Resemble Aging After Facial Allotransplantation. American Journal Of Transplantation 2015, 16: 968-978. PMID: 26639618, DOI: 10.1111/ajt.13544.Peer-Reviewed Original ResearchConceptsLong-term outcomesFacial allograftFacial allotransplantationSuperior long-term outcomesShort-term resultsRisk-benefit assessmentSoft tissue volumeSignificant volume lossTransplant recipientsVolume lossDiagnostic evaluationDonor selectionMuscle biopsyHistological evaluationComputed tomographyBone atrophyAllograftsFuture clinical routineNormal anatomyRecipient tissuesAllotransplantationClinical routineMorphometric changesSoft tissueMuscle fibersNoninvasive Monitoring of Immune Rejection in Face Transplant Recipients
Kueckelhaus M, Imanzadeh A, Fischer S, Kumamaru K, Alhefzi M, Bueno E, Wake N, Gerhard-Herman M, Rybicki F, Pomahac B. Noninvasive Monitoring of Immune Rejection in Face Transplant Recipients. Plastic & Reconstructive Surgery 2015, 136: 1082-1089. PMID: 26505709, DOI: 10.1097/prs.0000000000001703.Peer-Reviewed Original ResearchConceptsFace transplant recipientsTransplant recipientsChronic rejectionCLINICAL QUESTION/LEVELAllograft biopsy specimensTotal vessel diameterSolid organ allograftsAllograft lossOrgan allograftsPostsurgical monitoringFlap arteryControl subjectsBiopsy specimensIntimal thicknessClinical signsRadial arteryThicker intimaUltrasound biomicroscopyFacial arteryMedia thicknessHistologic analysisImmune rejectionArteryRecipientsInterobserver correlation