2009
Tissue Biomarkers for Prognosis in Cutaneous Melanoma: A Systematic Review and Meta-analysis
Rothberg BE, Bracken MB, Rimm DL. Tissue Biomarkers for Prognosis in Cutaneous Melanoma: A Systematic Review and Meta-analysis. Journal Of The National Cancer Institute 2009, 101: 452-474. PMID: 19318635, PMCID: PMC2720709, DOI: 10.1093/jnci/djp038.Peer-Reviewed Original ResearchConceptsCohort studyCutaneous melanomaMelanoma cell adhesion moleculeSystematic reviewEarly-stage cutaneous melanomaPotential prognostic valueMatrix metalloproteinase-2Cell nuclear antigenREMARK criteriaAdjuvant therapyMultivariable analysisREMARK guidelinesRisk stratificationPrognostic valueSurvival outcomesIncomplete adherenceMelanoma outcomesClinical managementImmunohistochemical expressionCell adhesion moleculeInclusion criteriaKi-67Tissue biomarkersClinical practiceMetalloproteinase-2
2006
E-cadherin Immunohistochemical Expression as a Prognostic Factor in Infiltrating Ductal Carcinoma of the Breast: a Systematic Review and Meta-Analysis
Gould Rothberg BE, Bracken MB. E-cadherin Immunohistochemical Expression as a Prognostic Factor in Infiltrating Ductal Carcinoma of the Breast: a Systematic Review and Meta-Analysis. Breast Cancer Research And Treatment 2006, 100: 139-148. PMID: 16791476, DOI: 10.1007/s10549-006-9248-2.Peer-Reviewed Original ResearchConceptsDuctal breast carcinomaBreast cancer-specific mortalityCancer-specific mortalityE-cadherin expressionCause mortalityBreast carcinomaCohort studyPrognostic markerImmunohistochemical expressionSystematic reviewSubstantial inter-study heterogeneityIndependent negative prognostic indicatorRetrospective cohort studyPrimary study outcomeSummary hazard ratioNegative prognostic indicatorInter-study heterogeneityRandom-effects modelClinical data collectionAbsent E-cadherin expressionNon-significant associationCadherin immunohistochemical expressionHazard ratioPrognostic factorsDuctal carcinoma