Featured Publications
Reinventing positive-strand RNA virus reverse genetics
Lindenbach BD. Reinventing positive-strand RNA virus reverse genetics. Advances In Virus Research 2022, 112: 1-29. PMID: 35840179, PMCID: PMC9273853, DOI: 10.1016/bs.aivir.2022.03.001.Chapters
2022
The In Vivo and In Vitro Architecture of the Hepatitis C Virus RNA Genome Uncovers Functional RNA Secondary and Tertiary Structures
Wan H, Adams RL, Lindenbach BD, Pyle AM. The In Vivo and In Vitro Architecture of the Hepatitis C Virus RNA Genome Uncovers Functional RNA Secondary and Tertiary Structures. Journal Of Virology 2022, 96: e01946-21. PMID: 35353000, PMCID: PMC9044954, DOI: 10.1128/jvi.01946-21.Peer-Reviewed Original ResearchConceptsSecondary structure mapRNA genomeRNA structureTertiary structureProtein-coding genesPositive-strand RNA virusesRegulatory RNA structuresFull-length structureHCV RNA genomeValuable model systemRNA structural motifsSecondary structural elementsEvolutionary functional analysisLife cycleVirus life cycleCellular contextCorresponding transcriptsImportant human pathogenLong RNAsGenomeSame RNAGenomic RNAComprehensive atlasFunctional analysisFunctional importance
2016
The Coding Region of the HCV Genome Contains a Network of Regulatory RNA Structures
Pirakitikulr N, Kohlway A, Lindenbach BD, Pyle AM. The Coding Region of the HCV Genome Contains a Network of Regulatory RNA Structures. Molecular Cell 2016, 62: 111-120. PMID: 26924328, PMCID: PMC4826301, DOI: 10.1016/j.molcel.2016.01.024.Peer-Reviewed Original ResearchConceptsRNA structureRegulatory RNA structuresComparative sequence analysisStructural RNA motifsRNA structure modelingLife cycleVirus life cycleRNA motifsPrimary sequenceCoding regionsGenomeBiological processesChemical probingSequence analysisRegulatory roleTertiary structureConformational changesVirus genomeFunctional assaysVersatile macromoleculesSpecific stagesStructure modelingFunctional informationMotifC virus genome
2005
Unravelling hepatitis C virus replication from genome to function
Lindenbach BD, Rice CM. Unravelling hepatitis C virus replication from genome to function. Nature 2005, 436: 933-938. PMID: 16107832, DOI: 10.1038/nature04077.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsGene Expression Regulation, ViralGenome, ViralHepacivirusHumansRNA, ViralViral ProteinsVirus ReplicationComplete Replication of Hepatitis C Virus in Cell Culture
Lindenbach BD, Evans MJ, Syder AJ, Wölk B, Tellinghuisen TL, Liu CC, Maruyama T, Hynes RO, Burton DR, McKeating JA, Rice CM. Complete Replication of Hepatitis C Virus in Cell Culture. Science 2005, 309: 623-626. PMID: 15947137, DOI: 10.1126/science.1114016.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, MonoclonalAntibodies, ViralAntigens, CDAntiviral AgentsCell Line, TumorCentrifugation, Density GradientCulture Media, ConditionedGenome, ViralHepacivirusHumansInterferon-alphaMutationNeutralization TestsRepliconRNA, ViralSerial PassageTetraspanin 28TransfectionViral Envelope ProteinsViral Nonstructural ProteinsVirionVirus CultivationVirus ReplicationConceptsHepatitis C virus (HCV) life cyclePutative HCV receptorFull-length HCV genomeHepatitis C virusViral glycoprotein E2Cell culturesVirus particlesHCV receptorsC virusVirus life cycleHCV genomeGlycoprotein E2Important human pathogenAntiviral compoundsImproved antiviralsViral entryMonoclonal antibodiesCellular expressionInfectious unitsHuman pathogensVitro systemHCVccAntiviralsReplication