2011
Structural Insights into RNA Recognition by RIG-I
Luo D, Ding SC, Vela A, Kohlway A, Lindenbach BD, Pyle AM. Structural Insights into RNA Recognition by RIG-I. Cell 2011, 147: 409-422. PMID: 22000018, PMCID: PMC3222294, DOI: 10.1016/j.cell.2011.09.023.Peer-Reviewed Original ResearchConceptsPathogen-associated molecular patternsTerminal regulatory domainProtein familyRegulatory domainProtein domainsInsertion domainRNA recognitionMolecular basisATP hydrolysisStructural insightsIntracellular RIGRNAMolecular patternsMotor domainLike receptorsAntiviral immune responseViral RNANanomechanical FunctionDomainHelicasesComplex interplayHelicaseCladeHel2DsRNA
2009
Hepatitis C Virus NS2 Protein Contributes to Virus Particle Assembly via Opposing Epistatic Interactions with the E1-E2 Glycoprotein and NS3-NS4A Enzyme Complexes
Phan T, Beran RK, Peters C, Lorenz IC, Lindenbach BD. Hepatitis C Virus NS2 Protein Contributes to Virus Particle Assembly via Opposing Epistatic Interactions with the E1-E2 Glycoprotein and NS3-NS4A Enzyme Complexes. Journal Of Virology 2009, 83: 8379-8395. PMID: 19515772, PMCID: PMC2738163, DOI: 10.1128/jvi.00891-09.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAmino Acid SubstitutionCarrier ProteinsHepacivirusHumansIntracellular Signaling Peptides and ProteinsModels, MolecularMolecular Sequence DataMutation, MissenseProtein BindingProtein Interaction MappingSuppression, GeneticViral Envelope ProteinsViral Nonstructural ProteinsViral ProteinsVirus AssemblyConceptsHepatitis C Virus NS2 ProteinVirus particle assemblyNS2 proteinVirus assemblyReverse genetic analysisForward genetic selectionSecond-site mutationsNS2 mutantsSuppressor mutationsRNA bindingEpistatic interactionsBiochemical experimentsGenetic analysisEnzyme complexSevere defectsNonstructural proteinsGenetic selectionParticle assemblyRNA replicationCell culture systemMutationsNS3-NS4AProteinMutantsMutual exclusivity
1999
Genetic Interaction of Flavivirus Nonstructural Proteins NS1 and NS4A as a Determinant of Replicase Function
Lindenbach B, Rice C. Genetic Interaction of Flavivirus Nonstructural Proteins NS1 and NS4A as a Determinant of Replicase Function. Journal Of Virology 1999, 73: 4611-4621. PMID: 10233920, PMCID: PMC112502, DOI: 10.1128/jvi.73.6.4611-4621.1999.Peer-Reviewed Original ResearchConceptsNonstructural protein 1Genetic interactionsRNA replicationViral RNA replicationGenetic screenSuppressor mutantsExtracytoplasmic compartmentsReplicase functionCytoplasmic complexDeletion mutantsReplicase componentsSingle mutationYellow fever virusProtein 1Additional mutationsNS1 geneRelated virusesInfected cellsIndependent selectionNS4A genesMutantsMutationsGenesReplicationDengue virus
1994
Processing in the hepatitis C virus E2-NS2 region: identification of p7 and two distinct E2-specific products with different C termini
Lin C, Lindenbach B, Prágai B, McCourt D, Rice C. Processing in the hepatitis C virus E2-NS2 region: identification of p7 and two distinct E2-specific products with different C termini. Journal Of Virology 1994, 68: 5063-5073. PMID: 7518529, PMCID: PMC236449, DOI: 10.1128/jvi.68.8.5063-5073.1994.Peer-Reviewed Original Research