1995
CD4 and CD45 regulate qualitatively distinct patterns of calcium mobilization in individual CD4+ T cells
Leitenberg D, Constant S, Lu D, Smith B, Bottomly K. CD4 and CD45 regulate qualitatively distinct patterns of calcium mobilization in individual CD4+ T cells. European Journal Of Immunology 1995, 25: 2445-2451. PMID: 7589109, DOI: 10.1002/eji.1830250906.Peer-Reviewed Original ResearchConceptsIntracellular calcium concentrationCalcium mobilizationSustained increaseT cellsCell activationCalcium concentrationCross-linking CD4Antigen-presenting cellsIntracellular calcium mobilizationT cell interactionsT cell activationT cell receptor complexT cell receptor signalingDistinct patternsCell receptor signalingIndividual CD4Cell receptor complexCD4Extracellular calciumCD3Specific antigenCross-linking antibodiesCalcium spikesCalcium fluxReceptor signaling
1992
A gamma delta+ T-cell leukemia bearing a novel t(8;14)(q24;q11) translocation demonstrates spontaneous in vitro natural killer-like activity.
Maziarz R, Arceci R, Bernstein S, Frazier L, Smith B, Kasai M, Tantravahi R, Strominger J. A gamma delta+ T-cell leukemia bearing a novel t(8;14)(q24;q11) translocation demonstrates spontaneous in vitro natural killer-like activity. Blood 1992, 79: 1523-31. PMID: 1532137, DOI: 10.1182/blood.v79.6.1523.bloodjournal7961523.Peer-Reviewed Original ResearchConceptsNatural killer-like activityT-cell leukemiaClinical conditionsNon-major histocompatibility complexPatient's clinical conditionGamma delta TCRTumor cell lysisFresh leukemic blastsDelta 1 gene segmentIntracellular calcium fluxGamma delta lineageT cell linesHuman T-cell leukemiaLeukemic blastsCytolytic activityDelta TCRLeukemia blastsC-myc proto-oncogene locusCalcium fluxCell surface analysisHistocompatibility complexDelta lineageLeukemiaLeukemia cellsProto-oncogene locusA γδ+ T-Cell Leukemia Bearing a Novel t(8;14)(q24;q11) Translocation Demonstrates Spontaneous In Vitro Natural Killer-Like Activity
Maziarz R, Arced R, Bernstein S, Frazier L, Smith B, Kasai M, Tantravahi R, Strominger J. A γδ+ T-Cell Leukemia Bearing a Novel t(8;14)(q24;q11) Translocation Demonstrates Spontaneous In Vitro Natural Killer-Like Activity. Blood 1992, 79: 1523-1531. DOI: 10.1182/blood.v79.6.1523.1523.Peer-Reviewed Original ResearchNatural killer-like activityT-cell leukemiaClinical conditionsNon-major histocompatibility complexPatient's clinical conditionGamma delta TCRTumor cell lysisFresh leukemic blastsDelta 1 gene segmentIntracellular calcium fluxGamma delta lineageT cell linesHuman T-cell leukemiaLeukemic blastsCytolytic activityDelta TCRLeukemia blastsC-myc proto-oncogene locusCalcium fluxCell surface analysisHistocompatibility complexDelta lineageLeukemiaLeukemia cellsProto-oncogene locus