1999
Use of rituximab and irradiated donor-derived lymphocytes to control Epstein–Barr virus-associated lymphoproliferation in patients undergoing related haplo-identical stem cell transplantation
McGuirk J, Seropian S, Howe G, Smith B, Stoddart L, Cooper D. Use of rituximab and irradiated donor-derived lymphocytes to control Epstein–Barr virus-associated lymphoproliferation in patients undergoing related haplo-identical stem cell transplantation. Bone Marrow Transplantation 1999, 24: 1253-1258. PMID: 10642818, DOI: 10.1038/sj.bmt.1702052.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntibodies, MonoclonalAntibodies, Monoclonal, Murine-DerivedAntigens, ViralAntineoplastic AgentsBlood Component TransfusionBlood DonorsDNA, ViralGraft vs Host DiseaseHematologic NeoplasmsHematopoietic Stem Cell TransplantationHerpesvirus 4, HumanHumansImmunosuppression TherapyLymphocytesLymphoproliferative DisordersMalePolymerase Chain ReactionRituximabConceptsEpstein-Barr virus-associated lymphoproliferative disorderStem cell transplantationEBV DNA titersB cell populationsCell transplantationTherapeutic strategiesEpstein-Barr virus-associated lymphoproliferationHaplo-identical stem cell transplantationEffective alternative therapeutic strategyAllogeneic stem cell transplantationCourses of rituximabDonor-derived lymphocytesPost-transplant immunosuppressionMonoclonal B-cell populationCD20 monoclonal antibodyCell populationsAlternative therapeutic strategiesImmunosuppressive medicationsSevere GVHDHost diseaseLymphocyte infusionPost transplantFatal complicationCurative therapyLymphoproliferative disorders
1991
Selective depletion of bone marrow T lymphocytes with anti-CD5 monoclonal antibodies: effective prophylaxis for graft-versus-host disease in patients with hematologic malignancies
Antin J, Bierer B, Smith B, Ferrara J, Guinan E, Sieff C, Golan D, Macklis R, Tarbell N, Lynch E. Selective depletion of bone marrow T lymphocytes with anti-CD5 monoclonal antibodies: effective prophylaxis for graft-versus-host disease in patients with hematologic malignancies. Blood 1991, 78: 2139-2149. DOI: 10.1182/blood.v78.8.2139.bloodjournal7882139.Peer-Reviewed Original ResearchAnti-CD5 MoAbHigh-risk patientsGraft failureHost diseaseHematologic malignanciesT cellsEpstein-Barr virus-associated lymphoproliferative disorderBone marrowActuarial event-free survivalBone marrow T lymphocytesAnti-CD5 monoclonal antibodyDiagnosis of myelodysplasiaMarrow T lymphocytesEvent-free survivalLow-risk patientsLate graft failureTotal body irradiationSignificant risk factorsRisk of relapseMajor histocompatibility complexActuarial survivalAcute graftAcute GVHDChronic GVHDEvaluable patientsSelective Depletion of Bone Marrow T Lymphocytes With Anti-CD5 Monoclonal Antibodies: Effective Prophylaxis for Graft-Versus-Host Disease in Patients With Hematologic Malignancies
Antin J, Bierer B, Smith B, Ferrara J, Guinan E, Sieff C, Golan D, Macklis R, Tarbell N, Lynch E, Reichert T, Blythman H, Bouloux C, Rappeport J, Burakoff S, Weinstein H. Selective Depletion of Bone Marrow T Lymphocytes With Anti-CD5 Monoclonal Antibodies: Effective Prophylaxis for Graft-Versus-Host Disease in Patients With Hematologic Malignancies. Blood 1991, 78: 2139-2149. PMID: 1717080, DOI: 10.1182/blood.v78.8.2139.2139.Peer-Reviewed Original ResearchConceptsAnti-CD5 MoAbHigh-risk patientsGraft failureHost diseaseHematologic malignanciesT cellsEpstein-Barr virus-associated lymphoproliferative disorderBone marrowActuarial event-free survivalBone marrow T lymphocytesAnti-CD5 monoclonal antibodyDiagnosis of myelodysplasiaMarrow T lymphocytesEvent-free survivalLow-risk patientsLate graft failureTotal body irradiationSignificant risk factorsRisk of relapseMajor histocompatibility complexActuarial survivalAcute graftAcute GVHDChronic GVHDEvaluable patients
1990
Depletion of bone marrow T-lymphocytes with an anti-CD5 monoclonal immunotoxin (ST-1 immunotoxin): effective prophylaxis for graft-versus-host disease.
Antin JH, Bierer BE, Smith BR, Guinan EC, Provost MM, Ferrara J, Macklis RM, Tarbell NJ, Blythman H, Bouloux C. Depletion of bone marrow T-lymphocytes with an anti-CD5 monoclonal immunotoxin (ST-1 immunotoxin): effective prophylaxis for graft-versus-host disease. Progress In Clinical And Biological Research 1990, 333: 207-15. PMID: 1689852.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAntibodies, MonoclonalAntigens, CDAntigens, DifferentiationBone MarrowBone Marrow CellsBone Marrow TransplantationCD5 AntigensChildChild, PreschoolCombined Modality TherapyCyclophosphamideCytarabineDrug EvaluationGraft vs Host DiseaseHumansImmunotoxinsLeukemiaMiddle AgedMyelodysplastic SyndromesRicinRisk FactorsT-LymphocytesWhole-Body Irradiation
1989
Monoclonal and Oligoclonal Gammopathy After Bone Marrow Transplantation
Mitus A, Stein R, Rappeport J, Antin J, Weinstein H, Alper C, Smith B. Monoclonal and Oligoclonal Gammopathy After Bone Marrow Transplantation. Blood 1989, 74: 2764-2768. DOI: 10.1182/blood.v74.8.2764.2764.Peer-Reviewed Original ResearchBone marrow transplantationMonoclonal gammopathyMarrow transplantationSyngeneic bone marrow transplantationM-componentEarly B cell ontogenySerum protein electrophoresesSyngeneic graft recipientsT lymphocyte subsetsDevelopment of graftImmunoglobulin G typeB cell populationsOligoclonal gammopathyPatients posttransplantationDays posttransplantationHost diseaseGraft recipientsB cell ontogenyGammopathyTransplantationPosttransplantationPatientsUbiquitous findingCorrelation of recoveryG-typeMonoclonal and oligoclonal gammopathy after bone marrow transplantation.
Mitus A, Stein R, Rappeport J, Antin J, Weinstein H, Alper C, Smith B. Monoclonal and oligoclonal gammopathy after bone marrow transplantation. Blood 1989, 74: 2764-8. PMID: 2819246, DOI: 10.1182/blood.v74.8.2764.bloodjournal7482764.Peer-Reviewed Original ResearchConceptsBone marrow transplantationMonoclonal gammopathyMarrow transplantationSyngeneic bone marrow transplantationM-componentEarly B cell ontogenySerum protein electrophoresesSyngeneic graft recipientsT lymphocyte subsetsDevelopment of graftImmunoglobulin G typeB cell populationsOligoclonal gammopathyPatients posttransplantationDays posttransplantationHost diseaseGraft recipientsB cell ontogenyGammopathyTransplantationPosttransplantationPatientsUbiquitous findingCorrelation of recoveryG-typeA large proportion of T lymphocytes lack CD5 expression after bone marrow transplantation.
Bierer B, Burakoff S, Smith B. A large proportion of T lymphocytes lack CD5 expression after bone marrow transplantation. Blood 1989, 73: 1359-66. PMID: 2467708, DOI: 10.1182/blood.v73.5.1359.bloodjournal7351359.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, MonoclonalAntigens, DifferentiationAntigens, Differentiation, T-LymphocyteBone Marrow TransplantationCalciumCD3 ComplexCD5 AntigensCytoplasmCytotoxicity, ImmunologicGraft vs Host DiseaseHumansImmunologic Deficiency SyndromesInterleukin-2Leukocyte CountMicePhenotypeReceptors, Antigen, T-CellT-Lymphocytes, CytotoxicConceptsBone marrow transplantationCD5 expressionMarrow transplantationT cellsAllogeneic bone marrow transplantationFrequency of CD3Major histocompatibility complex compatibilityT-cell depletionPercent of CD8Expression of CD5Presence of graftBMT patientsTotal CD3Host diseaseInterstitial pneumonitisPreparative regimenPeripheral bloodT lymphocytesB cellsCD3Lectin stimulationPatientsNormal populationTransplantationCD5A Large Proportion of T Lymphocytes Lack CD5 Expression After Bone Marrow Transplantation
Bierer B, Burakoff S, Smith B. A Large Proportion of T Lymphocytes Lack CD5 Expression After Bone Marrow Transplantation. Blood 1989, 73: 1359-1366. DOI: 10.1182/blood.v73.5.1359.1359.Peer-Reviewed Original ResearchBone marrow transplantationCD5 expressionMarrow transplantationT cellsAllogeneic bone marrow transplantationFrequency of CD3Major histocompatibility complex compatibilityT-cell depletionPercent of CD8Expression of CD5Presence of graftBMT patientsTotal CD3Host diseaseInterstitial pneumonitisPreparative regimenPeripheral bloodT lymphocytesB cellsCD3Lectin stimulationPatientsNormal populationTransplantationCD5
1987
B lymphocyte reconstitution after human bone marrow transplantation. Leu-1 antigen defines a distinct population of B lymphocytes.
Antin JH, Ault KA, Rappeport JM, Smith BR. B lymphocyte reconstitution after human bone marrow transplantation. Leu-1 antigen defines a distinct population of B lymphocytes. Journal Of Clinical Investigation 1987, 80: 325-332. PMID: 3112184, PMCID: PMC442241, DOI: 10.1172/jci113076.Peer-Reviewed Original ResearchConceptsLeu-1B cellsMarrow transplantationHuman bone marrow transplantationEffect of GVHDHuman marrow transplantationBone marrow transplantationEx vivo treatmentInterleukin-2 receptorB lymphocyte reconstitutionSeparate B cell lineageNormal B cellsB-cell lineageAcute GVHDChronic graftHost diseaseLymphocyte reconstitutionDonor originVivo treatmentB lymphocytesMultivariate analysisStages of differentiationGVHDTransplantationMarrow
1986
HTLV-III infection after bone marrow transplantation.
Antin JH, Smith BR, Ewenstein BM, Arceci RJ, Lipton JM, Page PL, Rappeport JM. HTLV-III infection after bone marrow transplantation. Blood 1986, 67: 160-3. PMID: 3000475, DOI: 10.1182/blood.v67.1.160.bloodjournal671160.Peer-Reviewed Original ResearchConceptsGraft-v-host diseaseHTLV-III infectionBone marrow transplantationHTLV-IIIMarrow transplantationChronic graft-v-host diseaseBone marrow transplant recipientsAcquisition of antibodiesChronic GVHD diseaseLate opportunistic infectionsLoss of immunocompetenceOnly risk factorMarrow transplant recipientsPeripheral blood lymphocytesTransfusion-associated AIDSGVHD diseaseLymphocyte phenotypingHost diseaseTransplant recipientsImmunodeficiency syndromeOpportunistic infectionsAsymptomatic individualsPatient's immunodeficiencyRisk factorsSevere immunodeficiencyHTLV-III Infection After Bone Marrow Transplantation
Antin J, Smith B, Ewenstein B, Arceci R, Lipton J, Page P, Rappeport J. HTLV-III Infection After Bone Marrow Transplantation. Blood 1986, 67: 160-163. DOI: 10.1182/blood.v67.1.160.160.Peer-Reviewed Original ResearchGraft-v-host diseaseHTLV-III infectionBone marrow transplantationHTLV-IIIMarrow transplantationChronic graft-v-host diseaseBone marrow transplant recipientsAcquisition of antibodiesChronic GVHD diseaseLate opportunistic infectionsLoss of immunocompetenceOnly risk factorMarrow transplant recipientsPeripheral blood lymphocytesTransfusion-associated AIDSGVHD diseaseLymphocyte phenotypingHost diseaseTransplant recipientsImmunodeficiency syndromeOpportunistic infectionsAsymptomatic individualsPatient's immunodeficiencyRisk factorsSevere immunodeficiency
1985
Isolated thrombocytopenia after allogeneic bone marrow transplantation: existence of transient and chronic thrombocytopenic syndromes.
First LR, Smith BR, Lipton J, Nathan DG, Parkman R, Rappeport JM. Isolated thrombocytopenia after allogeneic bone marrow transplantation: existence of transient and chronic thrombocytopenic syndromes. Blood 1985, 65: 368-74. PMID: 3881142, DOI: 10.1182/blood.v65.2.368.bloodjournal652368.Peer-Reviewed Original ResearchConceptsBone marrow transplantationMarrow transplantationThrombocytopenic syndromesChronic GVHDIsolated thrombocytopeniaPlatelet countThrombocytopenic patientsTransient thrombocytopeniaAllogeneic bone marrow transplantationSevere acute graftTrimethoprim-sulfamethoxazole administrationPeripheral platelet destructionTotal body irradiationBone marrow biopsyNormal platelet countAdverse patient prognosisNumber of megakaryocytesAcute graftIneffective thrombopoiesisPretransplant preparationHost diseasePreparatory regimensBody irradiationPlatelet destructionPlatelet precursorsIsolated Thrombocytopenia After Allogeneic Bone Marrow Transplantation: Existence of Transient and Chronic Thrombocytopenic Syndromes
First L, Smith B, Lipton J, Nathan D, Parkman R, Rappeport J. Isolated Thrombocytopenia After Allogeneic Bone Marrow Transplantation: Existence of Transient and Chronic Thrombocytopenic Syndromes. Blood 1985, 65: 368-374. DOI: 10.1182/blood.v65.2.368.368.Peer-Reviewed Original ResearchBone marrow transplantationMarrow transplantationThrombocytopenic syndromesChronic GVHDIsolated thrombocytopeniaPlatelet countThrombocytopenic patientsTransient thrombocytopeniaAllogeneic bone marrow transplantationSevere acute graftTrimethoprim-sulfamethoxazole administrationPeripheral platelet destructionTotal body irradiationBone marrow biopsyNormal platelet countAdverse patient prognosisNumber of megakaryocytesAcute graftIneffective thrombopoiesisPretransplant preparationHost diseasePreparatory regimensBody irradiationPlatelet destructionPlatelet precursors
1984
ISOLATED THROMBOCYTOPENIA FOLLOWING ALLOGENEIC BONE MARROW TRANSPLANTATION
First L, Smith B, Lipton J, Nathan D, Parkman R, Rappeport J. ISOLATED THROMBOCYTOPENIA FOLLOWING ALLOGENEIC BONE MARROW TRANSPLANTATION. Pediatric Research 1984, 18: 240-240. DOI: 10.1203/00006450-198404001-00880.Peer-Reviewed Original ResearchBone marrow transplantationMarrow transplantationManifestations of GVHDSevere acute graftTrimethoprim-sulfamethoxazole therapyDays post transplantAllogeneic bone marrowTotal body irradiationNormal platelet countAcute graftChronic GVHDHost diseasePost transplantPreparatory regimensBody irradiationIsolated thrombocytopeniaTransient syndromePlatelet countPost-TxSignificant complicationsChronic syndromeChronic thrombocytopeniaDrug therapyPatient prognosisTransient thrombocytopenia