2015
Impact of Molecular Clonality on Survival in Acute Myeloid Leukemia
Schulz W, Durant T, Rinder H, Tormey C, Torres R, Smith B, Hager K, Howe J, Siddon A. Impact of Molecular Clonality on Survival in Acute Myeloid Leukemia. Blood 2015, 126: 1385. DOI: 10.1182/blood.v126.23.1385.1385.Peer-Reviewed Original ResearchDe novo acute myeloid leukemiaNovo acute myeloid leukemiaAcute myeloid leukemiaMolecular clonalityAML patientsTumor heterogeneityMyeloid leukemiaNext-generation sequencingNormal-risk subjectsAdverse prognostic indicatorTime of diagnosisFurther prospective studiesLong-term outcomesFLT3-ITD mutationHigh-risk groupChoice of therapyFirst prospective evidenceLimited clinical utilityHigh-risk classificationEarly survivalStudy patientsOverall survivalPatient agePatient subsetsInitial diagnosis
2005
Development of a BCR/ABL Real-Time Quantitative RT-PCR Assay and Correlation with an Existing Qualitative Test.
Howe J, Crouch J, Smith B. Development of a BCR/ABL Real-Time Quantitative RT-PCR Assay and Correlation with an Existing Qualitative Test. Blood 2005, 106: 4879. DOI: 10.1182/blood.v106.11.4879.4879.Peer-Reviewed Original ResearchChronic myeloid leukemiaRT-PCR testPatient samplesBcr/abl translocationQuantitative RT-PCR testBCR/ABLReal-time quantitative RTRT-PCR assaysCML patientsMyeloid leukemiaTherapeutic agentsTumor cellsQualitative testQuantitative RTPatientsInitial screenNegative resultsRT-PCR screenQuantitative testPCR assaysAssaysTesting strategiesQualitative screenSpecific primersComplete correlation