2006
Transcerebral Platelet Activation After Aortic Cross-Clamp Release is Linked to Neurocognitive Decline
Mathew JP, Rinder HM, Smith BR, Newman MF, Rinder CS. Transcerebral Platelet Activation After Aortic Cross-Clamp Release is Linked to Neurocognitive Decline. The Annals Of Thoracic Surgery 2006, 81: 1644-1649. PMID: 16631650, DOI: 10.1016/j.athoracsur.2005.12.070.Peer-Reviewed Original ResearchConceptsCross-clamp removalAortic cross-clamp removalCardiopulmonary bypassPlatelet activationNeurocognitive injuryCognitive deficitsNeurocognitive declineElective coronary artery bypass graft surgeryCoronary artery bypass graft surgeryAortic cross-clamp releaseArtery bypass graft surgeryBypass graft surgeryCross-clamp releaseSubset of patientsVenous blood samplesJugular venous blood samplesJugular venous bloodCPB patientsGraft surgeryCardiac surgeryPatient subsetsInjury scoreAortic archVenous bloodCognitive injury
2005
Atrial Fibrillation After Cardiac Surgery/Cardiopulmonary Bypass Is Associated with Monocyte Activation
Fontes ML, Mathew JP, Rinder HM, Zelterman D, Smith BR, Rinder CS. Atrial Fibrillation After Cardiac Surgery/Cardiopulmonary Bypass Is Associated with Monocyte Activation. Anesthesia & Analgesia 2005, 101: 17-23. PMID: 15976199, DOI: 10.1213/01.ane.0000155260.93406.29.Peer-Reviewed Original ResearchConceptsPostoperative atrial fibrillationC-reactive proteinPreoperative C-reactive proteinCardiopulmonary bypassAtrial fibrillationCardiac surgerySinus rhythmAortic cross-clamp releaseTroponin IPilot studyCross-clamp releaseSubset of patientsCardiac muscle damageNormal sinus rhythmLeukocyte inflammatory responsesExploratory pilot studyPMN CD11bCPB patientsInflammatory infiltrationPMN countCD11b upregulationCellular inflammationInflammatory responseMonocyte activationMuscle damage
2003
Neutrophil CD11b upregulation during cardiopulmonary bypass is associated with postoperative renal injury
Rinder CS, Fontes M, Mathew JP, Rinder HM, Smith BR, Group M. Neutrophil CD11b upregulation during cardiopulmonary bypass is associated with postoperative renal injury. The Annals Of Thoracic Surgery 2003, 75: 899-905. PMID: 12645714, DOI: 10.1016/s0003-4975(02)04490-9.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAdultAgedCardiopulmonary BypassCD11b AntigenCoronary Artery BypassCreatinineHeart FailureHeart Valve Prosthesis ImplantationHemodynamicsHumansIntra-Aortic Balloon PumpingLeukocyte CountMiddle AgedNeutrophilsPostoperative ComplicationsProspective StudiesRisk FactorsSystemic Inflammatory Response SyndromeConceptsAcute renal injuryNeutrophil CD11b upregulationRenal injuryCardiopulmonary bypassInflammatory responseCD11b upregulationAdult respiratory distress syndromeMarkers of leukocytesPlatelet CD62P expressionPostoperative hemodynamic supportPostoperative renal injuryNeutrophil inflammatory responseSystemic inflammatory responseRespiratory distress syndromeSubset of patientsC-reactive proteinTotal neutrophil countMonocyte CD11bRenal riskHemodynamic instabilityInflammatory markersPost-CPBHemodynamic supportMyeloperoxidase levelsNeutrophil count
1993
Reticulated platelets in the evaluation of thrombopoietic disorders.
Rinder HM, Munz UJ, Ault KA, Bonan JL, Smith BR. Reticulated platelets in the evaluation of thrombopoietic disorders. Archives Of Pathology & Laboratory Medicine 1993, 117: 606-10. PMID: 8503732.Peer-Reviewed Original ResearchConceptsImmune platelet destructionImmune thrombocytopeniaPlatelet destructionNormal subjectsImmune thrombocytopenic purpuraThird of patientsSubset of patientsPlatelet determinationAbsence of megakaryocytesPlatelet-associated IgGChemotherapy-induced thrombocytopeniaInvasive diagnostic testsPeripheral blood plateletsFlow cytometric assayIgG levelsThrombocytopenic purpuraReticulated plateletsImmune destructionPlatelet valuesPatientsPlatelet IgGBone marrowThrombocytopeniaIgG dataLaboratory diagnosis