A Low T Regulatory Cell Response May Contribute to Both Viral Control and Generalized Immune Activation in HIV Controllers
Hunt PW, Landay AL, Sinclair E, Martinson JA, Hatano H, Emu B, Norris PJ, Busch MP, Martin JN, Brooks C, McCune JM, Deeks SG. A Low T Regulatory Cell Response May Contribute to Both Viral Control and Generalized Immune Activation in HIV Controllers. PLOS ONE 2011, 6: e15924. PMID: 21305005, PMCID: PMC3031543, DOI: 10.1371/journal.pone.0015924.Peer-Reviewed Original ResearchMeSH KeywordsCase-Control StudiesCytomegalovirusHIVHIV InfectionsImmunityLymphocyte ActivationModels, ImmunologicalT-Cell Antigen Receptor SpecificityT-Lymphocytes, RegulatoryViremiaConceptsT cell activation levelsT cell responsesHigh T-cell activation levelsHIV-specific T-cell responsesRegulatory cell responsesHIV controllersImmune activationCell responsesCMV-specific T cellsT regulatory (Treg) cell responsesTreatment-mediated viral suppressionEffective adaptive immune responseCMV-specific CD4Generalized immune activationHIV-specific CD4Lower Treg frequenciesNon-AIDS morbiditiesT cell frequenciesT cell lossT-cell depletionT cell dysfunctionAbsence of therapyActivation levelsAdaptive immune responsesDevelopment of vaccines