2000
Mixed nicotinic–muscarinic properties of the α9 nicotinic cholinergic receptor
Verbitsky M, Rothlin C, Katz E, Elgoyhen A. Mixed nicotinic–muscarinic properties of the α9 nicotinic cholinergic receptor. Neuropharmacology 2000, 39: 2515-2524. PMID: 11044723, DOI: 10.1016/s0028-3908(00)00124-6.Peer-Reviewed Original ResearchConceptsOuter hair cellsCholinergic receptorsCholinergic compoundsAlpha9 nicotinic acetylcholine receptorHigh ACh concentrationsNicotinic cholinergic receptorsWeak partial agonistNicotinic acetylcholine receptorsCochlear outer hair cellsAgonist-evoked currentsAlpha9 receptorMuscarinic agonistsMaximal responseAcetylcholine receptorsPartial agonistACh concentrationPharmacological propertiesHair cellsReceptorsXenopus laevis oocytesAcetylcholineNative receptorAgonistsCompetitive typeLaevis oocytes
1999
The α9 Nicotinic Acetylcholine Receptor Shares Pharmacological Properties with Type A γ-Aminobutyric Acid, Glycine, and Type 3 Serotonin Receptors
Rothlin C, Katz E, Verbitsky M, Elgoyhen A. The α9 Nicotinic Acetylcholine Receptor Shares Pharmacological Properties with Type A γ-Aminobutyric Acid, Glycine, and Type 3 Serotonin Receptors. Molecular Pharmacology 1999, 55: 248-254. PMID: 9927615, DOI: 10.1124/mol.55.2.248.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcholineAnimalsBariumBicucullineCalciumChelating AgentsDNA, ComplementaryEgtazic AcidFemaleGABA AntagonistsGlycineGlycine AgentsIndolesMembrane PotentialsOocytesReceptors, GABA-AReceptors, GlycineReceptors, NicotinicReceptors, SerotoninReceptors, Serotonin, 5-HT3Recombinant Fusion ProteinsSerotoninSerotonin AntagonistsStrychnineTropisetronXenopus laevisConceptsPharmacological propertiesGamma-aminobutyric acid receptor antagonist bicucullineAlpha9 nicotinic acetylcholine receptorACh-evoked currentsAgonist maximal responseType 3 serotonin receptorReceptor antagonist bicucullineGlycinergic antagonist strychnineGamma-aminobutyric acidNicotinic acetylcholine receptorsSimilar pharmacological propertiesCochlear outer hair cellsOuter hair cellsConcentration-dependent mannerCys-loop familyAlpha9 nAChRAntagonist bicucullineAntagonist strychnineCholinergic receptorsΓ-aminobutyric acidCys-loop receptorsSerotonin receptorsMaximal responseAcetylcholine receptorsHair cells