Block of the α9 nicotinic receptor by ototoxic aminoglycosides
Rothlin C, Katz E, Verbitsky M, Vetter D, Heinemann S, Elgoyhen A. Block of the α9 nicotinic receptor by ototoxic aminoglycosides. Neuropharmacology 2000, 39: 2525-2532. PMID: 11044724, DOI: 10.1016/s0028-3908(00)00056-3.Peer-Reviewed Original ResearchConceptsAlpha9 nicotinic acetylcholine receptorConcentration of acetylcholineNicotinic acetylcholine receptorsOrgan of CortiOuter hair cellsConcentration-dependent mannerEfferent functionCholinergic receptorsOtotoxic aminoglycosidesNicotinic receptorsAcetylcholine receptorsNon-competitive typeAcetylcholineHair cellsAminoglycosidesGentamicinXenopus laevis oocytesReceptorsAminoglycoside antibioticsReversible actionAlpha9Rank orderPresent studyAntagonistic effectLaevis oocytesMixed nicotinic–muscarinic properties of the α9 nicotinic cholinergic receptor
Verbitsky M, Rothlin C, Katz E, Elgoyhen A. Mixed nicotinic–muscarinic properties of the α9 nicotinic cholinergic receptor. Neuropharmacology 2000, 39: 2515-2524. PMID: 11044723, DOI: 10.1016/s0028-3908(00)00124-6.Peer-Reviewed Original ResearchConceptsOuter hair cellsCholinergic receptorsCholinergic compoundsAlpha9 nicotinic acetylcholine receptorHigh ACh concentrationsNicotinic cholinergic receptorsWeak partial agonistNicotinic acetylcholine receptorsCochlear outer hair cellsAgonist-evoked currentsAlpha9 receptorMuscarinic agonistsMaximal responseAcetylcholine receptorsPartial agonistACh concentrationPharmacological propertiesHair cellsReceptorsXenopus laevis oocytesAcetylcholineNative receptorAgonistsCompetitive typeLaevis oocytes