2019
Caveolin-1 Regulates Atherogenesis by Attenuating Low-Density Lipoprotein Transcytosis and Vascular Inflammation Independently of Endothelial Nitric Oxide Synthase Activation
Ramírez CM, Zhang X, Bandyopadhyay C, Rotllan N, Sugiyama MG, Aryal B, Liu X, He S, Kraehling JR, Ulrich V, Lin CS, Velazquez H, Lasunción MA, Li G, Suárez Y, Tellides G, Swirski FK, Lee WL, Schwartz MA, Sessa WC, Fernández-Hernando C. Caveolin-1 Regulates Atherogenesis by Attenuating Low-Density Lipoprotein Transcytosis and Vascular Inflammation Independently of Endothelial Nitric Oxide Synthase Activation. Circulation 2019, 140: 225-239. PMID: 31154825, PMCID: PMC6778687, DOI: 10.1161/circulationaha.118.038571.Peer-Reviewed Original ResearchConceptsEndothelial nitric oxide synthaseDiet-induced atherosclerosisNO productionVascular inflammationENOS activationEndothelial nitric oxide synthase activationNitric oxide synthase activationAthero-protective functionsLipid metabolic factorsEndothelial cell inflammationNitric oxide synthaseWild-type miceMice Lacking ExpressionProduction of NOExtracellular matrix remodelingInflammatory primingHyperlipidemic miceInflammatory pathwaysAortic archCell inflammationOxide synthaseMetabolic factorsMouse modelAtherosclerosisInflammation
2006
Identification of Golgi-localized acyl transferases that palmitoylate and regulate endothelial nitric oxide synthase
Fernández-Hernando C, Fukata M, Bernatchez PN, Fukata Y, Lin MI, Bredt DS, Sessa WC. Identification of Golgi-localized acyl transferases that palmitoylate and regulate endothelial nitric oxide synthase. Journal Of Cell Biology 2006, 174: 369-377. PMID: 16864653, PMCID: PMC2064233, DOI: 10.1083/jcb.200601051.Peer-Reviewed Original ResearchConceptsHuman endothelial cellsComplementary DNAPalmitoylation-deficient mutantHuman embryonic kidney 293 cellsEmbryonic kidney 293 cellsEndothelial nitric oxide synthaseEndothelial cellsKidney 293 cellsDHHC enzymesN-myristoylationS-palmitoylationNew GolgiSubcellular localizationCDNA clonesPlasma membraneLipid modificationCytoplasmic aspectENOS localizationGolgi apparatusRegulatory roleENOS palmitoylationPalmitoyl transferaseGolgiNitric oxide synthaseAcyl transferase