2021
MMAB promotes negative feedback control of cholesterol homeostasis
Goedeke L, Canfrán-Duque A, Rotllan N, Chaube B, Thompson BM, Lee RG, Cline GW, McDonald JG, Shulman GI, Lasunción MA, Suárez Y, Fernández-Hernando C. MMAB promotes negative feedback control of cholesterol homeostasis. Nature Communications 2021, 12: 6448. PMID: 34750386, PMCID: PMC8575900, DOI: 10.1038/s41467-021-26787-7.Peer-Reviewed Original ResearchMeSH KeywordsAlkyl and Aryl TransferasesAnimalsCell Line, TumorCholesterolCholesterol, LDLFeedback, PhysiologicalGene Expression ProfilingHeLa CellsHep G2 CellsHomeostasisHumansHydroxymethylglutaryl CoA ReductasesLiverMice, Inbred C57BLMice, KnockoutPromoter Regions, GeneticReceptors, LDLRNA InterferenceSterol Regulatory Element Binding Protein 2ConceptsCholesterol biosynthesisCholesterol homeostasisMouse hepatic cell lineIntegrative genomic strategyIntricate regulatory networkMaster transcriptional regulatorCellular cholesterol levelsHMGCR activityLDL-cholesterol uptakeCholesterol levelsHuman hepatic cellsSterol contentGenomic strategiesTranscriptional regulatorsRegulatory networksIntracellular cholesterol levelsGene expressionUnexpected roleHepatic cell linesBiosynthesisMMABIntracellular levelsCell linesHomeostasisExpression of SREBP2
2015
Dietary lipids modulate the expression of miR‐107, an miRNA that regulates the circadian system
Daimiel‐Ruiz L, Klett‐Mingo M, Konstantinidou V, Micó V, Aranda JF, García B, Martínez‐Botas J, Dávalos A, Fernández‐Hernando C, Ordovás JM. Dietary lipids modulate the expression of miR‐107, an miRNA that regulates the circadian system. Molecular Nutrition & Food Research 2015, 59: 552-565. PMID: 25522185, PMCID: PMC4591752, DOI: 10.1002/mnfr.201400616.Peer-Reviewed Original ResearchConceptsCardiovascular diseaseMiR-107Cardio-protective effectsType 2 diabetesUnhealthy dietary habitsCircadian rhythmCaco-2 cellsCVD riskConjugated linoleic acidPharmacological treatmentProtective effectDietary habitsMetabolic disordersDietary lipidsPutative target genesDocosahexanoic acidRelevant transcription factorsMultiple metabolic pathwaysRole of miRNAsOwn promoterTranscription factorsTarget genesDiseaseGene resultsGene expression