2021
PCSK9 Activity Is Potentiated Through HDL Binding
Burnap SA, Sattler K, Pechlaner R, Duregotti E, Lu R, Theofilatos K, Takov K, Heusch G, Tsimikas S, Fernández-Hernando C, Berry SE, Hall WL, Notdurfter M, Rungger G, Paulweber B, Willeit J, Kiechl S, Levkau B, Mayr M. PCSK9 Activity Is Potentiated Through HDL Binding. Circulation Research 2021, 129: 1039-1053. PMID: 34601896, PMCID: PMC8579991, DOI: 10.1161/circresaha.121.319272.Peer-Reviewed Original ResearchConceptsProprotein convertase subtilisin/kexin type 9High-density lipoproteinSmall high-density lipoproteinHDL proteomeApolipoprotein C3Low-density lipoprotein receptor degradationPlasma proprotein convertase subtilisin/kexin type 9Convertase subtilisin/kexin type 9Subtilisin/kexin type 9Coronary artery diseaseLow-density lipoprotein uptakeArtery diseasePostprandial lipaemiaBruneck StudyPCSK9 levelsPostprandial responseTriglyceride levelsPlasma levelsApolipoprotein profilesSAPHIR studyIndependent cohortPhospholipid transfer proteinMagnetic resonancePCSK9 activityType 9
2006
Identification of Golgi-localized acyl transferases that palmitoylate and regulate endothelial nitric oxide synthase
Fernández-Hernando C, Fukata M, Bernatchez PN, Fukata Y, Lin MI, Bredt DS, Sessa WC. Identification of Golgi-localized acyl transferases that palmitoylate and regulate endothelial nitric oxide synthase. Journal Of Cell Biology 2006, 174: 369-377. PMID: 16864653, PMCID: PMC2064233, DOI: 10.1083/jcb.200601051.Peer-Reviewed Original ResearchConceptsHuman endothelial cellsComplementary DNAPalmitoylation-deficient mutantHuman embryonic kidney 293 cellsEmbryonic kidney 293 cellsEndothelial nitric oxide synthaseEndothelial cellsKidney 293 cellsDHHC enzymesN-myristoylationS-palmitoylationNew GolgiSubcellular localizationCDNA clonesPlasma membraneLipid modificationCytoplasmic aspectENOS localizationGolgi apparatusRegulatory roleENOS palmitoylationPalmitoyl transferaseGolgiNitric oxide synthaseAcyl transferase