2022
Targeting ferroptosis to treat colorectal cancer
Yan H, Talty R, Johnson C. Targeting ferroptosis to treat colorectal cancer. Trends In Cell Biology 2022, 33: 185-188. PMID: 36473802, DOI: 10.1016/j.tcb.2022.11.003.Peer-Reviewed Original ResearchConceptsProtein kinase BArachidonic acidColorectal cancer treatmentProtein kinaseKinase BMammalian targetKey pathwaysGlutathione metabolismFerroptosis inductionEnergy metabolismCRC treatmentColorectal cancerCRC pathogenesisFerroptosisCancer treatmentPromising targetNew conceptual avenuesMetabolismTreatmentHippoKinasePrimary strategyRapamycinTargetConceptual avenues
2016
Metabolite and Microbiome Interplay in Cancer Immunotherapy
Johnson CH, Spilker ME, Goetz L, Peterson SN, Siuzdak G. Metabolite and Microbiome Interplay in Cancer Immunotherapy. Cancer Research 2016, 76: 6146-6152. PMID: 27729325, PMCID: PMC5093024, DOI: 10.1158/0008-5472.can-16-0309.Peer-Reviewed Original ResearchConceptsMicrobial interactionsRole of metabolitesCancer metabolismColon cancerHost microbiomeBiological originCancer progressionAdenoma/carcinomaPolysaccharide matrixTherapeutic designMetabolomic analysisPotential modulatorsMechanism of actionMicrobiomePolyamine metabolitesCancer immunotherapyBacteriaProximal colonBiofilmsProtective biofilmRecent studiesCancer treatmentMetabolismFuture targetsMetabolites