2019
1,4-Dioxane as an emerging water contaminant: State of the science and evaluation of research needs
Godri Pollitt K, Kim JH, Peccia J, Elimelech M, Zhang Y, Charkoftaki G, Hodges B, Zucker I, Huang H, Deziel N, Murphy K, Ishii M, Johnson CH, Boissevain A, O'Keefe E, Anastas P, Orlicky D, Thompson DC, Vasiliou V. 1,4-Dioxane as an emerging water contaminant: State of the science and evaluation of research needs. The Science Of The Total Environment 2019, 690: 853-866. PMID: 31302550, DOI: 10.1016/j.scitotenv.2019.06.443.Peer-Reviewed Original ResearchAnalytical detectionHigh priority chemicalsChemical interactionWater contaminantsEnvironmental fateChlorinated solventsDioxanePriority chemicalsMaximum contaminant levelCommon adsorptionTreatment technologiesU.S. Environmental Protection AgencyContaminantsChemical characteristicsHuman health effectsContaminant levelsProbable human carcinogenEnvironmental Protection AgencyState maximum contaminant levelWidespread contaminationHealth effectsEffective public health policiesWater supplyRoute of exposureAdsorption
2017
Exposome-Scale Investigations Guided by Global Metabolomics, Pathway Analysis, and Cognitive Computing
Warth B, Spangler S, Fang M, Johnson CH, Forsberg EM, Granados A, Martin RL, Domingo-Almenara X, Huan T, Rinehart D, Montenegro-Burke JR, Hilmers B, Aisporna A, Hoang LT, Uritboonthai W, Benton HP, Richardson SD, Williams AJ, Siuzdak G. Exposome-Scale Investigations Guided by Global Metabolomics, Pathway Analysis, and Cognitive Computing. Analytical Chemistry 2017, 89: 11505-11513. PMID: 28945073, DOI: 10.1021/acs.analchem.7b02759.Peer-Reviewed Original ResearchConceptsUnique small moleculesChemical structureStraightforward elucidationSmall moleculesExposomics researchBiotransformation productsFood contaminantsComprehensive exposure assessmentSpecific biological effectsPotential toxicantsBiological effectsToxic effectsPathway analysisConcurrent exposureHuman healthMoleculesEnvironmental exposuresGlobal metabolomicsEnvironmental toxicantsMetabolomicsContaminantsExposure assessmentWide varietyElucidationToxicants