2023
Urinary Paraben Concentrations and Associations with the Periconceptional Urinary Metabolome: Untargeted and Targeted Metabolomics Analyses of Participants from the Early Pregnancy Study
Vollmar A, Rattray N, Cai Y, Jain A, Yan H, Deziel N, Calafat A, Wilcox A, Jukic A, Johnson C. Urinary Paraben Concentrations and Associations with the Periconceptional Urinary Metabolome: Untargeted and Targeted Metabolomics Analyses of Participants from the Early Pregnancy Study. Environmental Health Perspectives 2023, 131: 097006. PMID: 37702489, PMCID: PMC10498870, DOI: 10.1289/ehp12125.Peer-Reviewed Original ResearchConceptsUrinary paraben concentrationsDiet-related metabolitesEarly Pregnancy StudyUrinary metabolomePregnancy StudyParaben concentrationsReproductive functionMultivariable linear regressionFemale reproductive functionDietary exposure assessmentUltrahigh-performance liquid chromatography-quadrupole timeMetabolomic analysisParaben exposureProspective cohortLiquid chromatography-quadrupole timeOrthogonal partial least squares discriminant analysisPericonceptional periodPotential confoundersUrinary concentrationsMetabolomic markersNutritional epidemiologyUnivariate statistical analysisExposure informationCritical windowUrine samples
2019
Normalizing Untargeted Periconceptional Urinary Metabolomics Data: A Comparison of Approaches
Vollmar A, Rattray NJW, Cai Y, Santos-Neto ÁJ, Deziel NC, Jukic AMZ, Johnson CH. Normalizing Untargeted Periconceptional Urinary Metabolomics Data: A Comparison of Approaches. Metabolites 2019, 9: 198. PMID: 31546636, PMCID: PMC6835889, DOI: 10.3390/metabo9100198.Peer-Reviewed Original ResearchUrinary metabolomics dataKidney functionOrthogonal partial least squares discriminant analysisUntargeted mass spectrometry-based metabolomics analysisCreatinine adjustmentUrine samplesMetabolomic analysisEarly-life exposomeMass spectrometry-based metabolomics analysisTime of conceptionSpecific gravity adjustmentCritical developmental windowMaternal urineEarly pregnancyPericonceptional periodUrinary concentrationsPost-implantation samplesUrinary dilutionUntargeted metabolomics analysisUrine concentrationsUnsupervised principal component analysisStudy objectiveDevelopmental windowMetabolomics dataMetabolomics studies