2019
Metabolic dysregulation in vitamin E and carnitine shuttle energy mechanisms associate with human frailty
Rattray NJW, Trivedi DK, Xu Y, Chandola T, Johnson CH, Marshall AD, Mekli K, Rattray Z, Tampubolon G, Vanhoutte B, White IR, Wu FCW, Pendleton N, Nazroo J, Goodacre R. Metabolic dysregulation in vitamin E and carnitine shuttle energy mechanisms associate with human frailty. Nature Communications 2019, 10: 5027. PMID: 31690722, PMCID: PMC6831565, DOI: 10.1038/s41467-019-12716-2.Peer-Reviewed Original ResearchConceptsRisk of frailtySocial care costsSubstantial economic burdenAnalysis of serumFrailty indexGas chromatography-mass spectrometry metabolomicsMetabolic dysregulationEconomic burdenVitamin ECare costsPoor healthPopulation-level assessmentFrailtyOlder peopleLongitudinal validationMetabolic phenotypeGlobal AGEingLater lifeMultivariate regressionSignificant metabolitesCarnitine shuttleDysregulationGreater proportionHealthPhenotype
2012
Novel metabolites and roles for α-tocopherol in humans and mice discovered by mass spectrometry–based metabolomics
Johnson CH, Slanař O, Krausz KW, Kang DW, Patterson AD, Kim JH, Luecke H, Gonzalez FJ, Idle JR. Novel metabolites and roles for α-tocopherol in humans and mice discovered by mass spectrometry–based metabolomics. American Journal Of Clinical Nutrition 2012, 96: 818-830. PMID: 22952181, PMCID: PMC3441109, DOI: 10.3945/ajcn.112.042929.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAlpha-TocopherolAmino AcidsAnimalsCholesterolChromansChromatography, High Pressure LiquidFemaleGlucuronidesHumansLiverMaleMetabolomicsMiceMice, Inbred C57BLMolecular StructureSpecies SpecificitySpectrometry, Mass, Electrospray IonizationTaurineVitamin E DeficiencyYoung AdultConceptsVitamin EUrinary metabolitesMass spectrometry-based metabolomicsNovel urinary metaboliteLiver fatty acidLiver cholesterolC57BL/6 miceChronic diseasesClinical trialsΑ-tocopherolMouse modelNovel metabolitesVitamin E.Human volunteersDietary supplementsUltraperformance liquid chromatographyMiceSerum samplesInterindividual variationLiver samplesDosingSerumUrineFatty acidsMetabolites