2021
Intratumour microbiome associated with the infiltration of cytotoxic CD8+ T cells and patient survival in cutaneous melanoma
Zhu G, Su H, Johnson CH, Khan SA, Kluger H, Lu L. Intratumour microbiome associated with the infiltration of cytotoxic CD8+ T cells and patient survival in cutaneous melanoma. European Journal Of Cancer 2021, 151: 25-34. PMID: 33962358, PMCID: PMC8184628, DOI: 10.1016/j.ejca.2021.03.053.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overBacteriaBacterial LoadBacterial TranslocationChemokinesClostridialesCytotoxicity, ImmunologicFemaleGastrointestinal MicrobiomeHumansLymphocyte CountLymphocytes, Tumor-InfiltratingMaleMelanomaMiddle AgedPrognosisSkin NeoplasmsT-Lymphocytes, CytotoxicTumor MicroenvironmentYoung AdultConceptsT cellsCutaneous melanomaPatient survivalGut microbiomeAdjusted hazard ratioT cell infiltrationChemokine gene expressionChemokine levelsCytotoxic CD8Hazard ratioSystemic inflammationShorter survivalCCL5 expressionPatient outcomesCD8Immune responseMortality riskGut microbiotaSurvival analysisMelanomaTumor nicheHuman cancersSurvivalSignificant correlationPositive association
2012
Novel metabolites and roles for α-tocopherol in humans and mice discovered by mass spectrometry–based metabolomics
Johnson CH, Slanař O, Krausz KW, Kang DW, Patterson AD, Kim JH, Luecke H, Gonzalez FJ, Idle JR. Novel metabolites and roles for α-tocopherol in humans and mice discovered by mass spectrometry–based metabolomics. American Journal Of Clinical Nutrition 2012, 96: 818-830. PMID: 22952181, PMCID: PMC3441109, DOI: 10.3945/ajcn.112.042929.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAlpha-TocopherolAmino AcidsAnimalsCholesterolChromansChromatography, High Pressure LiquidFemaleGlucuronidesHumansLiverMaleMetabolomicsMiceMice, Inbred C57BLMolecular StructureSpecies SpecificitySpectrometry, Mass, Electrospray IonizationTaurineVitamin E DeficiencyYoung AdultConceptsVitamin EUrinary metabolitesMass spectrometry-based metabolomicsNovel urinary metaboliteLiver fatty acidLiver cholesterolC57BL/6 miceChronic diseasesClinical trialsΑ-tocopherolMouse modelNovel metabolitesVitamin E.Human volunteersDietary supplementsUltraperformance liquid chromatographyMiceSerum samplesInterindividual variationLiver samplesDosingSerumUrineFatty acidsMetabolites