Genomics of Immune Diseases and New Therapies
Lenardo M, Lo B, Lucas CL. Genomics of Immune Diseases and New Therapies. Annual Review Of Immunology 2015, 34: 1-29. PMID: 26735698, PMCID: PMC5736009, DOI: 10.1146/annurev-immunol-041015-055620.Peer-Reviewed Original ResearchConceptsDNA sequencing technologiesMagnesium transportersSequencing technologiesNew genetic diseasesGenomicsGenetic lossGenetic diseasesMolecular definitionGenetic pathogenesisPatient phenotypesBiochemical investigationsImmune regulationImmune diseasesPrecision medicine treatmentImmunological diseasesNew therapiesGenetic counselingTransportersAdditional examplesPhenotypeRegulationGreat advancesImproved diagnosisIdentifying genetic determinants of autoimmunity and immune dysregulation
Lucas CL, Lenardo MJ. Identifying genetic determinants of autoimmunity and immune dysregulation. Current Opinion In Immunology 2015, 37: 28-33. PMID: 26433354, PMCID: PMC5583726, DOI: 10.1016/j.coi.2015.09.001.Peer-Reviewed Original ResearchConceptsHematopoietic stem cell transplantationStem cell transplantationCommon autoimmune diseaseHealth care costsRare immune diseasesMendelian disease mutationsExperiments of natureMendelian inheritance patternImmune dysregulationAutoimmune diseasesCell transplantationChronic diseasesDisease-causing genesImmune regulationImmune diseasesImmunological diseasesHuman locusTherapeutic targetCare costsGenetic insightsDiseaseDisease mutationsGenetic determinantsPolygenic diseaseDisease susceptibility